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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 7 of 7. This is the beginning of the thread.
Posted by KaraS on November 9, 2004, at 13:43:38
How concerned should we be about the potential for developing movement disorders from low dosage APs like Amisulpride for depression or Seroquel for sleep/anti-anxiety?
Posted by lostforwards on November 9, 2004, at 14:29:23
In reply to Low Dose APs and movement disorders?, posted by KaraS on November 9, 2004, at 13:43:38
It always depends on the individual but I'd say Seroquel is a safe low dose choice. It's the weakest binding AP I've heard of. You probably won't have anything to worry about at 25-50mg. Seroquel is great for anxiety.
I think knowing what to look for, especially if the benefits outweight the risks, is the best you can do. Of course, if you don't need it don't take it.
You especially need to watch out for masked TD.
(i.e try tappering off and waiting to see if anything shows up. ) I think this is true: sometimes the lowered dopamine levels mask the supersensitivity if it's occurred. I personally believe this is what's happened in my case of akinesia and TD.In contrast:
Risperdal caused me some severe TD problems at what's considered a low dose ( 2mg - 3mg ) which has showed up as sterotypies. I also had a twitching eyebrow that disappeared when the TD got more severe while I developed akinesia. I won't explain the details of my experience with Risperdal. I'll only say, at low doses, for a short term ( 3 weeks ), it's been extermely harmful to me. I've also read other peoples accounts stating the same thing except not as bad - just eyebrow twtiching for example.One thing about Risperdal is it's a very tight binding AP. I would've been better off with Seroquel and I would've chosen it had I known I'd have this problem.
Just make sure you look out for side-effects when you take them. I wasn't doing this and it's screwed me over.
Posted by KaraS on November 9, 2004, at 15:24:37
In reply to Re: Low Dose APs and movement disorders?, posted by lostforwards on November 9, 2004, at 14:29:23
> It always depends on the individual but I'd say Seroquel is a safe low dose choice. It's the weakest binding AP I've heard of. You probably won't have anything to worry about at 25-50mg. Seroquel is great for anxiety.
>
> I think knowing what to look for, especially if the benefits outweight the risks, is the best you can do. Of course, if you don't need it don't take it.
>
> You especially need to watch out for masked TD.
> (i.e try tappering off and waiting to see if anything shows up. ) I think this is true: sometimes the lowered dopamine levels mask the supersensitivity if it's occurred. I personally believe this is what's happened in my case of akinesia and TD.
>
> In contrast:
> Risperdal caused me some severe TD problems at what's considered a low dose ( 2mg - 3mg ) which has showed up as sterotypies. I also had a twitching eyebrow that disappeared when the TD got more severe while I developed akinesia. I won't explain the details of my experience with Risperdal. I'll only say, at low doses, for a short term ( 3 weeks ), it's been extermely harmful to me. I've also read other peoples accounts stating the same thing except not as bad - just eyebrow twtiching for example.
>
> One thing about Risperdal is it's a very tight binding AP. I would've been better off with Seroquel and I would've chosen it had I known I'd have this problem.
>
> Just make sure you look out for side-effects when you take them. I wasn't doing this and it's screwed me over.
>
>Thanks. I'm considering trying Amisulpride and my friend is taking Seroquel for anxiety. I would be super vigilant about movement type of side effects and I'll tell my friend to do the same.
How are you doing now? I know you were going through a rough time recently. Are things any better?
Kara
Posted by Ted Brosnan on November 9, 2004, at 15:59:56
In reply to Re: Low Dose APs and movement disorders?, posted by lostforwards on November 9, 2004, at 14:29:23
2-3mg Risperdal is not low dose. For a person without schizophrenia a low dose means atmost 0.5mg -1mg.
Amisulpride is taken at 400-1200 mg for schizophrenia but for depression the dose should not exceed 50mg. Some report improvement at only 25mg.
The higher isn't the better here!
TD can occur at any dose at anytime and with simply any neuroleptic.
Personally I would stay away from APs.
> It always depends on the individual but I'd say Seroquel is a safe low dose choice. It's the weakest binding AP I've heard of. You probably won't have anything to worry about at 25-50mg. Seroquel is great for anxiety.
>
> I think knowing what to look for, especially if the benefits outweight the risks, is the best you can do. Of course, if you don't need it don't take it.
>
> You especially need to watch out for masked TD.
> (i.e try tappering off and waiting to see if anything shows up. ) I think this is true: sometimes the lowered dopamine levels mask the supersensitivity if it's occurred. I personally believe this is what's happened in my case of akinesia and TD.
>
> In contrast:
> Risperdal caused me some severe TD problems at what's considered a low dose ( 2mg - 3mg ) which has showed up as sterotypies. I also had a twitching eyebrow that disappeared when the TD got more severe while I developed akinesia. I won't explain the details of my experience with Risperdal. I'll only say, at low doses, for a short term ( 3 weeks ), it's been extermely harmful to me. I've also read other peoples accounts stating the same thing except not as bad - just eyebrow twtiching for example.
>
> One thing about Risperdal is it's a very tight binding AP. I would've been better off with Seroquel and I would've chosen it had I known I'd have this problem.
>
> Just make sure you look out for side-effects when you take them. I wasn't doing this and it's screwed me over.
>
>
Posted by lostforwards on November 10, 2004, at 7:57:37
In reply to Re: Low Dose APs and movement disorders? » lostforwards, posted by KaraS on November 9, 2004, at 15:24:37
The akinesia, anhedonia, and the amotivated feeling have improved a bit though my arms still don't swing. Unfortunately, the sterotypies are starting to become more obvious now.
When I'm not using my arms: My left arm will feel normal if it's bent at the elbow and my hand is up against my shoulder. Usually I'll just scratch my shoulder a lot. It's partially involuntary ( I can force myself not to do it ) but happens without my being aware a lot. My right arm feel like it wants to be raised a bit.
The problems generally get worse later in the day when I'm more alert. That's why I think it's masked TD. I'm *hoping* the problems that are appearing will eventually go away, as the TD-like movements in my fingers did. I've still got a long way to go.I'm planning on seeing a GP ( maybe even a neurologist after ) about these side-effects soon, as it seems like it's going to take a long time for it to go away on it's own.
Thanks for asking.
Posted by KaraS on November 10, 2004, at 14:16:20
In reply to Re: Low Dose APs and movement disorders?, posted by lostforwards on November 10, 2004, at 7:57:37
> The akinesia, anhedonia, and the amotivated feeling have improved a bit though my arms still don't swing. Unfortunately, the sterotypies are starting to become more obvious now.
>
> When I'm not using my arms: My left arm will feel normal if it's bent at the elbow and my hand is up against my shoulder. Usually I'll just scratch my shoulder a lot. It's partially involuntary ( I can force myself not to do it ) but happens without my being aware a lot. My right arm feel like it wants to be raised a bit.
> The problems generally get worse later in the day when I'm more alert. That's why I think it's masked TD. I'm *hoping* the problems that are appearing will eventually go away, as the TD-like movements in my fingers did. I've still got a long way to go.
>
> I'm planning on seeing a GP ( maybe even a neurologist after ) about these side-effects soon, as it seems like it's going to take a long time for it to go away on it's own.
>
> Thanks for asking.
>It seems like progress is slow, but at least there's progress. My fingers are crossed for you.
K
Posted by Shalom34Israel on November 12, 2004, at 19:12:40
In reply to Low Dose APs and movement disorders?, posted by KaraS on November 9, 2004, at 13:43:38
> How concerned should we be about the potential for developing movement disorders from low dosage APs like Amisulpride for depression or Seroquel for sleep/anti-anxiety?
>
>
>
In Israel, we are very concerned about people's individual rights. Anti-psychotics are not used here like in Amerika. Here in Israel, anti-psychotics only used for schizophrenia and bipolar disorder. Not for behavioral control, not for anxiety. NOTHING ELSE! People with mood disorders are more susceptible to TD than schizophrenics, so depressives please be careful.Shalom
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