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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 10 of 10. This is the beginning of the thread.
Posted by Kristel on October 31, 2004, at 12:54:04
Hello. Just wondering if this TCA has strong Serotonin reuptake inhibition?!
Thanks.
Posted by jboud24 on October 31, 2004, at 13:02:18
In reply to Does Nortriptyline act on serotonin ?!, posted by Kristel on October 31, 2004, at 12:54:04
Posted by ed_uk on October 31, 2004, at 13:46:14
In reply to No (nm), posted by jboud24 on October 31, 2004, at 13:02:18
Nortriptyline is an extremely weak serotonin reuptake inhibitor, so weak that this effect is probably insignificant.
Ed
Posted by jujube on October 31, 2004, at 15:10:39
In reply to Re: No, posted by ed_uk on October 31, 2004, at 13:46:14
What about Imipramine? Does this work on both serotonin and norepiphedrine? I have anxious depression and am looking for a new AD, having not had any real success with Paxil (worked great first time, but not second time); Prozac; Effexor and Celexa. Any other suggestions?
Thanks
Tamara
> Nortriptyline is an extremely weak serotonin reuptake inhibitor, so weak that this effect is probably insignificant.
> Ed
Posted by ed_uk on October 31, 2004, at 15:17:17
In reply to Re: No » ed_uk, posted by jujube on October 31, 2004, at 15:10:39
Imipramine (Tofranil) inhibits the reuptake of both serotonin and noradrenaline (norepinephrine). It can be effective for panic disorder, generalised anxiety and depression.
Ed
Posted by jujube on October 31, 2004, at 15:23:01
In reply to Re: No, posted by ed_uk on October 31, 2004, at 15:17:17
Wow! That was a fast response. Thanks. One more question, if you don't mind. Do you know if the side effects are bad to unbearable? Do the side effects wear off after a couple of weeks of treatment? Sorry for all the questions. I have a pdoc appointment on Tuesday, and I am trying to identify a new AD. I am a little afraid of the "older" ADs because of the potential for serious side effects. But, I can't go on like this much longer.
Thanks again.
Tamara
> Imipramine (Tofranil) inhibits the reuptake of both serotonin and noradrenaline (norepinephrine). It can be effective for panic disorder, generalised anxiety and depression.
> Ed
Posted by RetiredYoung on October 31, 2004, at 15:48:50
In reply to Re: No » ed_uk, posted by jujube on October 31, 2004, at 15:23:01
Hi Tamara - I'm in about the same boat as you. I'm thinking of trying Cymbalta. I'm currently taking a tricyclic (clomipramine) but it is not working as well as I'd hoped.
Jim
Posted by jujube on October 31, 2004, at 15:52:47
In reply to Re: No » jujube, posted by RetiredYoung on October 31, 2004, at 15:48:50
Thanks for the response. Unfortunately, Cymbalta is not an option for me. I live in Canada, and it is not yet available here. Oh well, my search continues. I wish you well in your own search to find an AD that works.
Take care.
Tamara
> Hi Tamara - I'm in about the same boat as you. I'm thinking of trying Cymbalta. I'm currently taking a tricyclic (clomipramine) but it is not working as well as I'd hoped.
>
> Jim
Posted by King Vultan on October 31, 2004, at 20:05:59
In reply to Re: No » ed_uk, posted by jujube on October 31, 2004, at 15:23:01
> Wow! That was a fast response. Thanks. One more question, if you don't mind. Do you know if the side effects are bad to unbearable? Do the side effects wear off after a couple of weeks of treatment? Sorry for all the questions. I have a pdoc appointment on Tuesday, and I am trying to identify a new AD. I am a little afraid of the "older" ADs because of the potential for serious side effects. But, I can't go on like this much longer.
>
> Thanks again.
>
> Tamara
>Of the two, I have only tried nortriptyline, but imipramine generally does have worse side effects, particularly anticholinergic effects like dry mouth and constipation. My opinion is that you have to have a certain willingness to put up with these side effects if you are going to take a tricyclic, but everyone has their limit. I considered both nortriptyline and desipramine to be tolerable, but the effects were so much more severe with protriptyline that they wound up exceeding my tolerance level.
Todd
Posted by jujube on October 31, 2004, at 20:28:32
In reply to Re: No » jujube, posted by King Vultan on October 31, 2004, at 20:05:59
> > Wow! That was a fast response. Thanks. One more question, if you don't mind. Do you know if the side effects are bad to unbearable? Do the side effects wear off after a couple of weeks of treatment? Sorry for all the questions. I have a pdoc appointment on Tuesday, and I am trying to identify a new AD. I am a little afraid of the "older" ADs because of the potential for serious side effects. But, I can't go on like this much longer.
> >
> > Thanks again.
> >
> > Tamara
> >
>
> Of the two, I have only tried nortriptyline, but imipramine generally does have worse side effects, particularly anticholinergic effects like dry mouth and constipation. My opinion is that you have to have a certain willingness to put up with these side effects if you are going to take a tricyclic, but everyone has their limit. I considered both nortriptyline and desipramine to be tolerable, but the effects were so much more severe with protriptyline that they wound up exceeding my tolerance level.
>
> ToddThanks Todd. I think I could handle some of the start-up side effects as long as they diminish or go away with treatment (few weeks?). At this point, I am more interested in finding something to pull me out of this black hole I have been living in so I can go back to my normal life.
Tamara
This is the end of the thread.
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