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Dr. Bob is Robert Hsiung, MD,
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Posted by linkadge on October 2, 2004, at 10:50:06
Ginkgo has some MAO inhibiting properties. So is it safe to combine the two ??
Linkdge
Posted by cache-monkey on October 2, 2004, at 14:26:55
In reply to safe to combine ginkgo with zoloft ?, posted by linkadge on October 2, 2004, at 10:50:06
> Ginkgo has some MAO inhibiting properties. So is it safe to combine the two ??
For what it's worth, I took ginko while I was on Celexa in order to try to mitigate the sexual side effects. It may have worked a little, but I wasn't back to normal. More importantly for your purposes: I didn't experience any adverse mental or physiological consequences.
I just did a search on it, and discovered the following study [link to abstract below]:
<<< Evidence that gingko biloba extract does not inhibit MAO A and B in living human brain.
Fowler JS, Wang GJ, Volkow ND, Logan J, Franceschi D, Franceschi M, MacGregor R, Shea C, Garza V, Liu N, Ding YS.
Department of Chemistry, Brookhaven National Laboratory, Upton, NY 11973-5000, USA. fowler@bnl.gov
Extracts of Ginkgo biloba have been reported to reversibly inhibit both monoamine oxidase (MAO) A and B in rat brain in vitro leading to speculation that MAO inhibition may contribute to some of its central nervous system effects. Here we have used positron emission tomography (PET) to measure the effects of Ginkgo biloba on human brain MAO A and B in 10 subjects treated for 1 month with 120 mg/day of the Ginkgo biloba extract EGb 761, using [11C]clorgyline and [11C]L-deprenyl-D2 to measure MAO A and B respectively. A three-compartment model was used to calculate the plasma to brain transfer constant K1 which is related to blood flow, and lambdak3, a model term which is a function of the concentration of catalytically active MAO molecules. Ginkgo biloba administration did not produce significant changes in brain MAO A or MAO B suggesting that mechanisms other than MAO inhibition need to be considered as mediating some of its CNS effects.
>>>
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=10698362&dopt=Abstractpeace,
cache-monkey
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