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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 7 of 7. This is the beginning of the thread.
Posted by waki on August 20, 2004, at 11:38:41
Linkadge,
I met with Yale research doc today. You were really correct on the different receptors.
Today I'm trying something new. I gather it is being assessed what clasification to put it under by the fda.
This med is unique because it's a dopamine balancer so to speak. It's potential is to adjust the individual receptors in either direction.
I gather in lamens language, it will increase the receptors that need it, and decrease receptors that need decreasing.
It has a fairly long half life so I want know for awhile what it does to me.
Posted by linkadge on August 20, 2004, at 17:00:50
In reply to Linkadge: Dopamene balance, posted by waki on August 20, 2004, at 11:38:41
Oh, are you taking part in a study ??
Anyhow, yes it really depends on both the individial and where the dopamine is going.
dopamine d1 agonistm *can* increase motivation
dopamine d2 agonistm *can* produce psychosis
dopamine d3 agonism *can* increase pleasue
d4 receptor is involved in novalty, though I am not sure weather agonism or antaganism would be responsable.
There is much more too, because it also depends on the location of the receptor. D2 receptor is involved in psychosis in the hippocamapas and lower brain stem, but is involved in movement in other areas of the brain. Much I don't understand but I know that taking a general uptake inhibitor like ritalin can produce mixed results.
Linkadge
Posted by Waki on August 20, 2004, at 18:17:13
In reply to Re: Linkadge: Dopamene balance, posted by linkadge on August 20, 2004, at 17:00:50
Yes, I am in an approximate 3 year treatment research study for depression.
I was told this drug utilizes these terms (agonism and antaganism) certain receptors of sertonin, dopemine. It does more, but I really don't get interested in these meds unless they work. This particular segment relates to inducing enjoyment. Today it's inducing sleep, heheeh :)
I going to PM dose it tomorrow, it really made me tired. One of the side effects I was to expect for awhile was drowsyness.You obviously have some background in this language. My engineering degree gives me the knowledge how it's made not what it does, heheh :)
Posted by owensmar on August 22, 2004, at 22:40:13
In reply to Re: Linkadge: Dopamene balance, posted by Waki on August 20, 2004, at 18:17:13
I sure hope this new drug works and when will it be out? I know it's dopamine I'm missing since I find it impossible to take pleasure in anything. I have no internal motivation, no enthusiasm.
Is Zyprexa a dopamine booster? Would it help with this? What other drugs might help? I'm on Effexor now.
Posted by linkadge on August 23, 2004, at 16:14:36
In reply to Re: Linkadge: Dopamene balance, posted by owensmar on August 22, 2004, at 22:40:13
zyprexa is actually a dopamine blocker. It blocks the d1 and d2 receptors. It can cause loss of motivation and perhaps apathy. Sometimes, however it is not so bad. It does not block the d3 receptor and so more avaiable dopamine can reach the D3 receptor wich can be involved in anhedonia.
When I took zyprexa, I was not anhedonic, but just didn;t have the energy to do much.
Linkadge
Posted by owensmar on August 23, 2004, at 17:34:53
In reply to Re: Linkadge: Dopamene balance, posted by linkadge on August 23, 2004, at 16:14:36
> zyprexa is actually a dopamine blocker. It blocks the d1 and d2 receptors. It can cause loss of motivation and perhaps apathy. Sometimes, however it is not so bad. It does not block the d3 receptor and so more avaiable dopamine can reach the D3 receptor wich can be involved in anhedonia.
>
> When I took zyprexa, I was not anhedonic, but just didn;t have the energy to do much.
>
>
> LinkadgeI don't get it then. I mean why would they prescribe it for unipolar depression (in addition to my regular A/D) to help boost my A/D effects. Because it's supposed to help with anxiety? Do I then have to choose between anxiety and apathy?
I am so tired of not caring about anything. I want to want something, you know? I want to have a desire, fulfill that desire, and then take pleasure in the fulfillment. It's been years...
Posted by zeugma on August 23, 2004, at 18:12:58
In reply to Re: Linkadge: Dopamene balance, posted by linkadge on August 23, 2004, at 16:14:36
When I took zyprexa, I was not anhedonic, but just didn;t have the energy to do much.>>>
I had exactly the same experience on Trilafon, a typical AP: no anhedonia, just an intense desire to stay in bed. More intense than usual, I mean.
-z
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