![[dr. bob]](/dr-bob-sm.gif)
Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 3 of 3. This is the beginning of the thread.
Posted by Questionmark on June 29, 2004, at 1:21:03
Does anyone know the difference between the two? How would an inhibitor of the former act differently (pharmacologically and behaviorally) than an inhibitor of the latter?
Thank you.
Posted by chemist on June 29, 2004, at 3:04:09
In reply to Acetylcholinesterase vs. cholinesterase, posted by Questionmark on June 29, 2004, at 1:21:03
> Does anyone know the difference between the two? How would an inhibitor of the former act differently (pharmacologically and behaviorally) than an inhibitor of the latter?
> Thank you.hello there, chemist here....may i respond in a day or two? there is an issue with neuronal and cerebrospinal enzymes, as well as quaternary amines.......all the best, chemist
Posted by Shawn. T. on June 29, 2004, at 19:44:19
In reply to Acetylcholinesterase vs. cholinesterase, posted by Questionmark on June 29, 2004, at 1:21:03
Acetylcholinesterase is a type of cholinesterase that is sometimes referred to as RBC (red blood cell) cholinesterase. Another major type of cholinesterase is butyrylcholinesterase, also known as serum cholinesterase or pseudocholinesterase. There are different isoforms (variants) for each type of cholinesterase. These enzymes catalyze the hydrolysis of esters of choline, but they may also exhibit other actions such as altering certain proteins. I've often seen people use the term cholinesterase to refer to acetylcholinesterase; one term is simply more specific than the other.
An inhibitor of acetylcholinesterase would act differently than an inhibitor of butyrylcholinesterase. I'm not especially familiar with the nature of these differences. Pfizer claims that drugs that selectively inhibit acetylcholinesterase have a better tolerability profile for Alzheimer's disease patients than drugs that inhibit both cholinesterases (see http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=14751402 ). On the other hand, others have suggested that drugs that inhibit both cholinesterases may offer greater benefits, perhaps in a certain subgroup(s) of Alzheimer's patients (see http://www.alzheimer-insights.com/insights/vol7no4/vol7no4.htm and http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=9403484 ). More research needs to be done to help us to better understand the different roles that these two enzymes play in the brain. There may be other types of endogenous cholinesterases in the body, but the two that I've mentioned are certainly the most important ones.
Shawn
This is the end of the thread.
Psycho-Babble Medication | Extras | FAQ
Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.org
Script revised: February 4, 2008
URL: http://www.dr-bob.org/cgi-bin/pb/mget.pl
Copyright 2006-17 Robert Hsiung.
Owned and operated by Dr. Bob LLC and not the University of Chicago.