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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 7 of 7. This is the beginning of the thread.
Posted by djmmm on October 1, 2003, at 17:16:46
Organon Says Mirtazapine More Effective Than SSRIs
LONDON (Reuters Health) Sept 22 - Organon's anti-depression drug Remeron SolTab (mirtazapine) works faster and is more effective than SSRIs, according to data on nearly 3000 patients released on Sunday.
Mirtazapine has a dual mechanism of action, enhancing noradrenaline and 5-HT transmission.
The new meta-analysis, presented at the 16th European College of Neuropsychopharmacology Congress in Prague, pooled the data from 12 clinical trials.
A total of 1485 patients were on mirtazapine and another 1485 patients were on SSRIs such as fluoxetine, paroxetine, citalopram, sertraline and fluvoxamine.
Michael Thase, professor of psychiatry at the University of Pittsburgh School of Medicine, said the findings showed that patients on mirtazapine "show a significantly quicker and significantly stronger response than patients receiving SSRIs."
For example, about 29% of patients on mirtazapine had responded to therapy after two weeks, compared with only 20% of patients on SSRIs. After four weeks, the response rates were 50% versus about 42%.
The time to first remission was significantly shorter with mirtazapine than with SSRIs, while the number of patients achieving remission was significantly larger with mirtazapine than SSRIs.
For example, about 12% of patients on mirtazapine were in remission after two weeks of therapy compared with about 7% of patients on SSRIs. After four weeks, it was 28% versus 22%.
"Onset of action of antidepressants can be considered a major factor for clinical success in the therapeutic treatment of depression," Dr. Thase said. "Patients often experience adverse events during the early weeks of treatment, so that a delayed onset hinders instant clinical improvement. Hence delayed onset can result in poor adherence to therapy."
The findings also showed that mirtazapine was significantly more effective than SSRIs in treating symptoms of anxiety, retardation and sleep disturbance.
There were no significant differences in rates of withdrawals from the study or adverse events between the two groups.
Posted by Ame Sans Vie on October 1, 2003, at 18:30:33
In reply to Organon Says Mirtazapine More Effective Than SSRIs, posted by djmmm on October 1, 2003, at 17:16:46
This just in: Organon so full of it their eyeballs are brown.
Posted by Janelle on October 1, 2003, at 19:26:07
In reply to Re: Organon Says Mirtazapine More Effective Than SSRIs, posted by Ame Sans Vie on October 1, 2003, at 18:30:33
Please go over to the Social Board and read my post! Thanks.
Posted by stjames on October 1, 2003, at 22:51:17
In reply to Organon Says Mirtazapine More Effective Than SSRIs, posted by djmmm on October 1, 2003, at 17:16:46
Given that Remeron in related to the TCA's and it has been well established the TCA's are more effective in treating serious depressions, this is no shock. Nor is it a surprise that meds mith multiple actions are more effective than single mode meds. In a word... DUH.
Posted by Penny on October 2, 2003, at 9:18:19
In reply to Re: Organon Says Mirtazapine More Effective Than S, posted by stjames on October 1, 2003, at 22:51:17
Certainly hasn't been any more effective for me, but I haven't had much luck with any of the ADs, SSRIs or otherwise. Yet, as with all of these meds, it's all individual.
Posted by crazychickuk on October 2, 2003, at 14:06:28
In reply to Re: Organon Says Mirtazapine More Effective Than S, posted by Penny on October 2, 2003, at 9:18:19
Well i have been on this med for 4 mnths now nearly and this is the only med that i can honestly say aint given me any bad side affects as of yet.. and i must admit, it must be helping me somehow, as i dont get as freaked out as before, and my pnaick attacks have minimized.... on 30mg... :)
Posted by Dr. Bob on October 2, 2003, at 19:48:05
In reply to AME SANS VIE! C'mere please! » Ame Sans Vie, posted by Janelle on October 1, 2003, at 19:26:07
> Please go over to the Social Board and read my post!
Here's a link:
http://www.dr-bob.org/babble/social/20030913/msgs/264814.html
Bob
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