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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 3 of 3. This is the beginning of the thread.
Posted by linkadge on August 27, 2003, at 10:50:05
is it beneficial to have more 5ht1a receptors or less.
Linkadge
Posted by Shawn. T. on August 27, 2003, at 21:53:14
In reply to question regarding receptors, posted by linkadge on August 27, 2003, at 10:50:05
The answer to your question probably depends on whether we're dealing with presynaptic 5-HT1A receptors (autoreceptors) or postsynaptic 5-HT1A receptors. My opinion is that having more postsynaptic 5-HT1A receptors in the hippocampus would be beneficial; however, the truly important factor is how often these receptors are activated. Also, it's important to consider the sensitivity of these receptors. Several different antidepressant drugs enhance the tonic activation of 5-HT1A receptors in the hippocampus (see http://www.jneurosci.org/cgi/content/full/18/23/10150 ). Furthermore, 5-HT1A activation in the hippocampus has been linked to the induction of neurogenesis (see http://jpet.aspetjournals.org/cgi/content/abstract/299/2/401 and http://www.sciencemag.org/cgi/content/abstract/301/5634/805 ). I'm less sure about postsynaptic 5-HT1A receptors in other regions of the brain; their "beneficial" effects probably vary depending on where they're located.
I'm not sure that the upregulation of presynaptic 5-HT1A autoreceptors has been shown to exhibit clear benefits; the matter is debatable. Again, the regularity of activation and sensitivity factors are probably as important or more important than the number of receptors. My personal opinion is that having a greater number 5-HT1A autoreceptors would be desirable in a person not taking a serotonergic drug like an SSRI; see http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=12684476&dopt=Abstract for some support for my point of view.
Shawn
Posted by Questionmark on August 29, 2003, at 0:16:27
In reply to Re: question regarding receptors » linkadge, posted by Shawn. T. on August 27, 2003, at 21:53:14
i would assume that, generally, the fewer 5-HT1A autoreceptors the better, and the more 5-HT1A postsynaptic receptors the better (in a simplistic, generalized sense, of course). This is bcz stimulation of the autoreceptors DEcreases serotonin secretion, and stimulation of the postsynaptic 5-HT1A receptors is, well, just good i think-- for the reasons that Shawn T. gave... and bcz i think that the beneficial effects of enhanced serotonin transmission are mediated mostly via the 5-HT1A postsynaptic receptors (but im not sure-- zthis correct?). Eh, hope this helped a little bit at least.
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