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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 11 of 11. This is the beginning of the thread.
Posted by falconman on April 14, 2003, at 19:33:54
Hi,
I've been taking oral selegiline(brand-Jumex)at 25mg/day for 5 days. I have noticed absolutely nothing , no side effects, no activating effects ect...I find this quite strange, especially considering how sensitive I've been to other meds in the past. I bought this off the internet from www.nubrain.com. Do you think they may have ripped me off, maybe given me some in-active pills? Would it be better to maybe swap to another brand like Eldepryl? Any thoughts would be greatly appreciated.
thanks
Mark
Posted by ACE on April 15, 2003, at 2:20:32
In reply to selegiline no effects, is this strange?, posted by falconman on April 14, 2003, at 19:33:54
> Hi,
> I've been taking oral selegiline(brand-Jumex)at 25mg/day for 5 days. I have noticed absolutely nothing , no side effects, no activating effects ect...
>
> I find this quite strange, especially considering how sensitive I've been to other meds in the past. I bought this off the internet from www.nubrain.com. Do you think they may have ripped me off, maybe given me some in-active pills? Would it be better to maybe swap to another brand like Eldepryl? Any thoughts would be greatly appreciated.
> thanks
> MarkHey Mark,
This reminds me of my experience for Lithium. 4 weeks on it - Nothing, no s/effects, no thereapeutic effects. It's like only the friggin' water is going down! It makes a grown man wan't to cry!
Anyhow, my blood levels of Lithium were 0.2 3 times! Each time on a higher dose! My Dr. said that maybe my stomach just doesn't suit Lithium - might be the case with you. But dude - keep it up, you've only had 5 days.
Lithium's fat ass is going to be kicked out of my house soon - a real dissapointment. Oh well, as they say in actor auditions...NEXT!
See you, bro,
Ace (Andrew)
Posted by falconman on April 15, 2003, at 6:36:56
In reply to Re: selegiline no effects, is this strange? » falconman, posted by ACE on April 15, 2003, at 2:20:32
> > Hi,
> > I've been taking oral selegiline(brand-Jumex)at 25mg/day for 5 days. I have noticed absolutely nothing , no side effects, no activating effects ect...
> >
> > I find this quite strange, especially considering how sensitive I've been to other meds in the past. I bought this off the internet from www.nubrain.com. Do you think they may have ripped me off, maybe given me some in-active pills? Would it be better to maybe swap to another brand like Eldepryl? Any thoughts would be greatly appreciated.
> > thanks
> > Mark
>
> Hey Mark,
>
> This reminds me of my experience for Lithium. 4 weeks on it - Nothing, no s/effects, no thereapeutic effects. It's like only the friggin' water is going down! It makes a grown man wan't to cry!
>
> Anyhow, my blood levels of Lithium were 0.2 3 times! Each time on a higher dose! My Dr. said that maybe my stomach just doesn't suit Lithium - might be the case with you. But dude - keep it up, you've only had 5 days.
>
> Lithium's fat ass is going to be kicked out of my house soon - a real dissapointment. Oh well, as they say in actor auditions...NEXT!
>
> See you, bro,
> Ace (Andrew)Easy,
Good to see you back and posting dude.
Yeah this med things weird. I'm gonna keep it up though and I've ordered the same stuff but a different brand from somewhere else. I still reckon I was ripped off.
I read your post on your Lithium trial- crazy situation, and you got that med off your doc too, so it must have been the real stuff. Hope you find what you need to irradicate the OCD.
Peace
Posted by Eddie Sylvano on April 15, 2003, at 10:38:39
In reply to selegiline no effects, is this strange?, posted by falconman on April 14, 2003, at 19:33:54
> Hi,
> I've been taking oral selegiline(brand-Jumex)at 25mg/day for 5 days. I have noticed absolutely nothing , no side effects, no activating effects ect...
--------------------Not unusual by my experience. I took essentially the same dosage (maybe a little more, even) for a few weeks without ever really noticing anything. At most, I'd say that it made me a bit more irritable and horny. I figured that I must not have any dopamine deficiency issues.
Posted by falconman on April 15, 2003, at 11:31:26
In reply to Re: selegiline no effects, is this strange? » falconman, posted by Eddie Sylvano on April 15, 2003, at 10:38:39
> > I've been taking oral selegiline(brand-Jumex)at 25mg/day for 5 days. I have noticed absolutely nothing , no side effects, no activating effects ect...
> --------------------
>
> Not unusual by my experience. I took essentially the same dosage (maybe a little more, even) for a few weeks without ever really noticing anything. At most, I'd say that it made me a bit more irritable and horny. I figured that I must not have any dopamine deficiency issues.
>Hi,
thanks for your response. I take it your not still on it then? How long did you try it for and if you don't mind for what symptoms?
Thanks
Posted by Eddie Sylvano on April 15, 2003, at 12:25:50
In reply to Re: selegiline no effects, is this strangeEddie , posted by falconman on April 15, 2003, at 11:31:26
> thanks for your response. I take it your not still on it then? How long did you try it for and if you don't mind for what symptoms?
------------------I took it for about 4 weeks (that's all I had bought), largely in an attempt to combat depressive symptoms (anhedonia, lack of libido). Maybe if I'd taken it longer, it would have shown more utility. I've batted around the idea of trying it again. I think that if you're going after the dopamine system, though, you're better served by trying buproprion.
Anyway, it wasn't a bad experience, just nothing really notable.
Posted by jparsell82 on April 16, 2003, at 17:47:40
In reply to selegiline no effects, is this strange?, posted by falconman on April 14, 2003, at 19:33:54
> Hi,
> I've been taking oral selegiline(brand-Jumex)at 25mg/day for 5 days. I have noticed absolutely nothing , no side effects, no activating effects ect...
>
> I find this quite strange, especially considering how sensitive I've been to other meds in the past. I bought this off the internet from www.nubrain.com. Do you think they may have ripped me off, maybe given me some in-active pills? Would it be better to maybe swap to another brand like Eldepryl? Any thoughts would be greatly appreciated.
> thanks
> MarkI don't think you've taken it long enough. Selegiline is like Nardil in that you have to take it for a weeks before you notice anti-depressive effects. Also, I know Selegiline is prescribed in doses like around 5-15mg for Parkinson's Disease. From what I remember reading, it's also effective for Depression but you have to take it in much higher doses.
Posted by jemma on April 16, 2003, at 18:28:49
In reply to selegiline no effects, is this strange?, posted by falconman on April 14, 2003, at 19:33:54
Maybe you were taking too much selegiline? Above 10 mg, it stops being selective for dopamine. I've been finding that seratonin pretty much cancels out dopamine benefits, but that could be just me. Also, I really recommend trying low-dose selegiline with modafinil for ADD. It's really worked for me.
- jemma
Posted by michael on April 17, 2003, at 2:30:11
In reply to Re: selegiline no effects, is this strange?, posted by jparsell82 on April 16, 2003, at 17:47:40
> > Hi,
> > I've been taking oral selegiline(brand-Jumex)at 25mg/day for 5 days. I have noticed absolutely nothing , no side effects, no activating effects ect...
> >
> > I find this quite strange, especially considering how sensitive I've been to other meds in the past. I bought this off the internet from www.nubrain.com. Do you think they may have ripped me off, maybe given me some in-active pills? Would it be better to maybe swap to another brand like Eldepryl? Any thoughts would be greatly appreciated.
> > thanks
> > Mark
>
> I don't think you've taken it long enough. Selegiline is like Nardil in that you have to take it for a weeks before you notice anti-depressive effects. Also, I know Selegiline is prescribed in doses like around 5-15mg for Parkinson's Disease. From what I remember reading, it's also effective for Depression but you have to take it in much higher doses.Not 100% certain about this, but I believe that effective doses for depression are (I think) typically at least 40mg?
Posted by michael on April 17, 2003, at 3:03:42
In reply to Re: selegiline no effects, is this strange? » falconman, posted by jemma on April 16, 2003, at 18:28:49
> Maybe you were taking too much selegiline? Above 10 mg, it stops being selective for dopamine. I've been finding that seratonin pretty much cancels out dopamine benefits, but that could be just me. Also, I really recommend trying low-dose selegiline with modafinil for ADD. It's really worked for me.
>
> - jemmaFwiw - it's not selective for dopamine... If I recall correctly, at doses 10mg (and below) it selectivly/preferentially inhibits the enzyme mao-b (as opposed to mao-a), which (I think) is what breaks down dopamine in the brain...
At higher doses, it still does that - its just that it also begins to inhibit mao-a (another enzyme which also affects neurotransmitters, as well as the gut - hence the food restrictions, etc.).
I may not have that exactly right - in fact, I'm sure that's not exactly right, but I think its a little closer... (just in case that matters, or anyone cares).
Posted by jemma on April 17, 2003, at 10:44:56
In reply to Re: selegiline no effects, is this strange?, posted by michael on April 17, 2003, at 3:03:42
> > Maybe you were taking too much selegiline? Above 10 mg, it stops being selective for dopamine. I've been finding that seratonin pretty much cancels out dopamine benefits, but that could be just me. Also, I really recommend trying low-dose selegiline with modafinil for ADD. It's really worked for me.
> >
> > - jemma
>
> Fwiw - it's not selective for dopamine... If I recall correctly, at doses 10mg (and below) it selectivly/preferentially inhibits the enzyme mao-b (as opposed to mao-a), which (I think) is what breaks down dopamine in the brain...
>
> At higher doses, it still does that - its just that it also begins to inhibit mao-a (another enzyme which also affects neurotransmitters, as well as the gut - hence the food restrictions, etc.).
>
> I may not have that exactly right - in fact, I'm sure that's not exactly right, but I think its a little closer... (just in case that matters, or anyone cares).
Yes, you're right, but the effect is the same - I was using shorthand. At 10 mg or less, selegiline inhibits MAO-B, which causes an increase in dopamine and phenylalamine. At higher doses, it becomes an MAO-A inhibitor as well, which causes an increase in seratonin and also inhibits the breakdown of taurine, giving rise to food restrictions. My point was that, for me, the increase in seratonin nullifies the increase in dopamine, so a dose of 5 or 10 mg is more effective both for depression and ADD.- jemma
This is the end of the thread.
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