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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 25 of 27. This is the beginning of the thread.
Posted by cybercafe on August 21, 2002, at 19:30:35
just started zyprexa 5mg for BP II anxiety, agitation, concentration, stability? ...i think zyprexa is supposed to have the lowest incidence of movement disorders
took my first dose, found it really hard to get out of bed ... a bit sedated afterward
any idea if these side effects (sedation) last or not.. if so, when do you notice them improving?
Posted by ross on August 21, 2002, at 22:00:21
In reply to starting Zyprexa, what can I expect?, posted by cybercafe on August 21, 2002, at 19:30:35
ive taken Zyprexa for 2 years. the tiredness sticks around for about a week and a half and you also get hungry.. 5mgs is a small dose so dont sweat it. Zypexa's side effects are tiny and go away in about 2 weeks........
Posted by melinda on August 21, 2002, at 22:00:54
In reply to starting Zyprexa, what can I expect?, posted by cybercafe on August 21, 2002, at 19:30:35
Hi cybercafe,
I've been taking Zyprexa for about 5 months. (I take it for schizophrenia.)
The sedation will probably go away after a few weeks...at least it did for me. I still sleep a lot at night, 10-12 hours, but I feel no sedation during the day.
Something to keep in mind is that Zyprexa is notorious for causing weight gain. I gained 10 lbs...all the weight gain occured during my first month of treatment. My appetite was ferocious and I had cravings for salt and carbohydrates.Take care,
melinda
Posted by cybercafe on August 21, 2002, at 23:55:42
In reply to Re: starting Zyprexa, what can I expect?, posted by melinda on August 21, 2002, at 22:00:54
> The sedation will probably go away after a few weeks...at least it did for me. I still sleep a lot at night, 10-12 hours, but I feel no sedation during the day.
Yahoo! just what i wanted to hear :)
> Something to keep in mind is that Zyprexa is notorious for causing weight gain. I gained 10 lbs...all the weight gain occured during my first month of treatment. My appetite was ferocious and I had cravings for salt and carbohydrates.
Mmmmmm food.. yummy! I just hope i can put weight on my arms and legs and it doesn't all go to my gut and neck :)
Posted by denise528 on August 22, 2002, at 6:01:30
In reply to Re: starting Zyprexa, what can I expect?, posted by cybercafe on August 21, 2002, at 23:55:42
Hi,
I found taking 10mg helped more than 5mg, if I took 10mg in the afternoon it knocked me out later but I felt so much better the next day, I actually felt my depression lift and felt more sociable.
5mg didn't seem to do much for me.
Denise
Posted by crepuscular on August 22, 2002, at 10:51:13
In reply to starting Zyprexa, what can I expect?, posted by cybercafe on August 21, 2002, at 19:30:35
i'm moving over to zyprexa from seroquel for bp II. i have found the atypicals to be great drugs for helping regulate sleep & mood cycling. since starting seroquel i've managed to save money for the first time in my life. but alas, my lips started twitching and neck eventually locked up to the point where i was a Gorgon head, a stone-headed goofball.
i'm actually hoping aripiprazole comes on the market soon. anybody know about this atypical?
crepuscular.
Posted by cybercafe on August 22, 2002, at 11:42:18
In reply to Re: starting Zyprexa, what can I expect?, posted by crepuscular on August 22, 2002, at 10:51:13
if the sedation is going to be there for a while i might as well try to start working right now .... but if it disappears really fast, perhaps i should wait a couple days (how many?) before applying for jobs(btw this dry mouth is awesome! without all of this saliva in my mouth, people can actually make out what i'm saying)
Posted by cybercafe on August 22, 2002, at 11:46:43
In reply to Re: starting Zyprexa, what can I expect?, posted by crepuscular on August 22, 2002, at 10:51:13
>starting seroquel i've managed to save money for the first time in my life. but alas, my lips
cool... same here, i say we take off to europe :)
>started twitching and neck eventually locked up to the point where i was a Gorgon head, a stone-headed goofball.
wow ... what dose were you on? and does that side effect go away when you stopped the drug?
it's weird... cuz i think drugs that raise blood pressure also cause tremors of hands and lips... i had that effect on effexor
> i'm actually hoping aripiprazole comes on the market soon. anybody know about this atypical?yeah... they said late in the 3rd quarter of 2002 no? ... so i guess not too many people have taken it yet :) ... it sounds wonderful and i can't wait, but still.. i would like other guinea pigs to try it before i do just to make sure it's safe :)
Posted by house on August 22, 2002, at 14:39:32
In reply to Re: starting Zyprexa, what can I expect?, posted by cybercafe on August 22, 2002, at 11:46:43
>There is no doubt that Zyprexa is a great drug. I take it for anxiety reasons, however i have developed some twitching throughout my body. Not really sure if it's TD or some other related movement disorder. Just be careful. PS. I am also at 5mg.
>starting seroquel i've managed to save money for the first time in my life. but alas, my lips
>
> cool... same here, i say we take off to europe :)
>
> >started twitching and neck eventually locked up to the point where i was a Gorgon head, a stone-headed goofball.
>
> wow ... what dose were you on? and does that side effect go away when you stopped the drug?
>
> it's weird... cuz i think drugs that raise blood pressure also cause tremors of hands and lips... i had that effect on effexor
>
>
> > i'm actually hoping aripiprazole comes on the market soon. anybody know about this atypical?
>
> yeah... they said late in the 3rd quarter of 2002 no? ... so i guess not too many people have taken it yet :) ... it sounds wonderful and i can't wait, but still.. i would like other guinea pigs to try it before i do just to make sure it's safe :)
>
Posted by denise528 on August 23, 2002, at 4:00:15
In reply to Re: starting Zyprexa, what can I expect?/Cybercafe, posted by house on August 22, 2002, at 14:39:32
Hi,
In what way is this drug more effective than the other antipsychotics?
Denise
Posted by crepuscular on August 23, 2002, at 10:40:53
In reply to Can you tell me more about aripiprazole?, posted by denise528 on August 23, 2002, at 4:00:15
hi,
i want to know more about this med too. i've not read that it was any better than the current atypicals, but it does represent a new dopamine receptor stabilization mechanism.
i also heard it may have a near-zero risk of TD/EPS and a neutral effect on weight, both of which are legit concerns.
c.
Posted by cybercafe on August 23, 2002, at 12:21:00
In reply to Re: Can you tell me more about aripiprazole?, posted by crepuscular on August 23, 2002, at 10:40:53
> i also heard it may have a near-zero risk of TD/EPS and a neutral effect on weight, both of which are legit concerns.
yes it sounds wonderful... but it's so new... would you be willing to be a "guinea pig"?
Posted by crepuscular on August 23, 2002, at 15:56:40
In reply to Re: Can you tell me more about aripiprazole?, posted by cybercafe on August 23, 2002, at 12:21:00
well, at this point i've been on so many meds and combinations, suffered side effects & setbacks, advances and poop outs, mixed 'em with pot & alcohol, etc., that i'm sure i hit "novel drug combination" status long ago. compounds unkown to science were formed in my neurons, interacting with an idiosyncratic biochemical substrate and producing synthetic states of consciousness hitherto unkown to man. it's freaky in there, where matter meets mind & the rubber hits road.
neurons dangle in the phosphate void, receptors bark for new binding regimes. my phone rings, Oregon burns to cinders, Bush bellows, terrorists plot, Chomsky rails.
so yeah, i'd be will to toss some 'pip into the mix.
Posted by nikioct73 on August 23, 2002, at 19:56:59
In reply to starting Zyprexa, what can I expect?, posted by cybercafe on August 21, 2002, at 19:30:35
I tried starting on Zyprexa at 5mg QHS and was sooooo damn sleepy all day i gave up after ..well it seemed like a week..but I was in such a fog i don't really know..
Posted by cybercafe on August 24, 2002, at 1:19:47
In reply to Re: starting Zyprexa, what can I expect?, posted by nikioct73 on August 23, 2002, at 19:56:59
> I tried starting on Zyprexa at 5mg QHS and was sooooo damn sleepy all day i gave up after ..well it seemed like a week..but I was in such a fog i don't really know..
so the sedation didn't lift at all after a week at the same dose? hmm...
Posted by nikioct73 on August 24, 2002, at 13:40:54
In reply to Re: starting Zyprexa, what can I expect?, posted by cybercafe on August 24, 2002, at 1:19:47
Now that I think back ...I was feeling like I was doing the Thorazine shuffle for about four days and then it did 'lift'..then it started all back again two days after ther lift..so thats when I gave up on it...I do have to say the couple of days I was not doped up I felt great...I was sorry to give it up but I have a job that demands I have most of my wits about me..
niki
Posted by action_jackson on August 26, 2002, at 23:56:56
In reply to starting Zyprexa, what can I expect?, posted by cybercafe on August 21, 2002, at 19:30:35
Goes for any antipsychotics -
How come so many bipolar's around here have EPS anyways???
Shit antipsychotics that's why....
Sorry the language but true is true.
Chad
ps let's hear any long term success stories with antipsychotics - guess what - there are few to none unless someone has mania or is skitzophrenic - in that case they likely still aren't super happy even well treated ...
Just IMO...
Posted by Dinah on August 27, 2002, at 5:06:42
In reply to GET OFF SHIT ZYPREXA UNLESS MANIC, posted by action_jackson on August 26, 2002, at 23:56:56
Hello Chad.
Dinah here, filling in for Dr. Bob (see notice at top of page).
It is against the guidelines of this site to use language that might be offensive to others. Here is a link to the civility guidelines.
http://www.dr-bob.org/babble/faq.html#civil
And as a reminder, the next step after a warning is for me to have to block you from posting for a week.
Thanks,
Dinah
Posted by sjb on August 27, 2002, at 9:55:05
In reply to Re: starting Zyprexa, what can I expect?, posted by nikioct73 on August 23, 2002, at 19:56:59
My experience was like cybercafe's. I think I called in sick all week, lay on a couch and everything was just like he/she said: a fog. To add to the misery it increased my appetite for baked goods, a big problem I have anyway. I was augemting with Ativan and WILL NEVER GO BACK.
Posted by NikkiT2 on August 27, 2002, at 14:31:40
In reply to GET OFF SHIT ZYPREXA UNLESS MANIC, posted by action_jackson on August 26, 2002, at 23:56:56
I've been on Zyprexa for about a year now and it has been a utter life saver. It has reduced my suicidal ideation hugely and I think I can say I wouldn't be here if my pdoc hadn't tried zyprexa.
I;m not cured and am still a mess, but the worst part for me (the suicidal side) had reduced significantly.
Nikki
Posted by sebastian on September 23, 2002, at 11:15:55
In reply to starting Zyprexa, what can I expect?, posted by cybercafe on August 21, 2002, at 19:30:35
<<just started zyprexa 5mg for BP II anxiety, agitation, concentration, stability? ...
i think zyprexa is supposed to have the lowest incidence of movement disorders
took my first dose, found it really hard to get out of bed ... a bit sedated afterward
any idea if these side effects (sedation) last or not.. if so, when do you notice them improving? >>
I found that I would have to force myself out of bed on 10Zp. You might feel kind of out of it during the day. It works for all the things you listed. It also slows your movement, sometimes more than you want. The side effects don't improve, you just learn to deal with them.
Sebastian
Posted by cybercafe on September 23, 2002, at 18:37:36
In reply to Re: starting Zyprexa, what can I expect?, posted by sebastian on September 23, 2002, at 11:15:55
> I found that I would have to force myself out of bed on 10Zp. You might feel kind of out of it during the day. It works for all the things you listed. It also slows your movement, sometimes more than you want. The side effects don't improve, you just learn to deal with them.
i dunno... my sedation and EPS are definately way better than when i first started
i kinda miss that sedation :(
Posted by hawkeye on September 23, 2002, at 18:59:51
In reply to Re: starting Zyprexa, what can I expect?, posted by sebastian on September 23, 2002, at 11:15:55
July 12, 2002
Duke Warning: Zyprexa-Diabetes Link
FYI
Since they arrived on the market in the 1990s, the so-called 'atypicial' antipsychotic drugs have been wrapped in controversy and promotional hype by drug companies and their paid professional spin masters who made bald claims about their "favorable side effect profile" referring to them as "breakthrough" "miracle" drugs that "balance the chemistry" in the brain.
In his book, Mad in America, Robert Whitaker relied on data available to the FDA but not made known to most doctors who prescribe these drugs or to patients and families. In clinical trials prior to FDA approval: "One in every 145 patients who entered the trials --for risperidone, olanzapine, quetiapine, and a fourth atypical called sertindole--died, and yet those deaths were never mentioned in the scientific literature." (p. 269)
It can be said, therefore, that contrary to what psychiatrists have been telling patients and their families, the drugs prescribed for schizophrenia have severe undesirable side effects. For some individuals, the side effects are fatal.
On July 1, 2002, Duke University issued a Press Release about the most recent finding that links the new anti-psychotics to early onset diabetes. The team of researchers--Elizabeth A. Koller, M.D. from the FDA, and Murali Doraiswamy, M.D. from Duke-- analyzed FDA's adverse drug report database, MedWatch (which receives 10% of adverse drug reports). They identified 289 cases of diabetes in patients who had been prescribed olanzapine (a.k.a. Zyprexa), Eli Lilly's most profitable drug.
The researchers reported: "Of the 289 cases of diabetes linked to the use of olanzapine, 225 were newly diagnosed cases. One hundred patients developed ketosis (a serious complication of diabetes), and 22 people developed pancreatitis, or inflammation of the pancreas, which is a life-threatening condition. There were 23 deaths, including that of a 15-year-old adolescent who died of necrotizing pancreatitis, a condition where the pancreas breaks down and dies. Most cases (71 percent) occurred within six months of starting the drug and many cases were associated with moderate weight gain."
The evidence from pre-marketing trials was also alarming: Whitaker wrote: "Of the 2,500 patients in the trials who received olanzapine, twenty died. Twelve killed themselves...Twenty-two percent [ ] suffered a 'serious' adverse event, compared to 18 percent of the haloperidol patients. Two-thirds of the olanzapine patients didn't successfully complete the trials...."(p. 281)
According to the Duke researchers, many cases of diabetes have also been reported with other antipsychotic drugs. In 1994, a Duke team first reported a Diabetes link to the first 'atypical' antipsychotic drug, clozapine: last year, 384 reports of diabetes last year were associated with clozapine.
Whereas the British Medical Control Agency and the Japanese Health & Welfare Ministry have issued warnings about the risk of diabetes for patients prescribed Zyprexa, FDA has remained silent.
It is astounding to AHRP that the FDA has approved a clinical trial that exposes teenagers-- who are not even diagnosed with schizophrenia-- to a drug that puts them at risk of diabetes. The trial is being conducted at Yale University. [See, AHRP complaint filed with the federal Office of Human Research Protection at: http://www.researchprotection.org/Initiatives/YaleComplaint.html]
~~~~~~~~~~~~~~~~~~~~~~~~~~~~
http://www.eurekalert.org/pub_releases/2002-07/dumc-rwa062802.php
Antipsychotic Drug Might Be Linked to Diabetes
HealthNewsDigest.com - July 01, 2002
RESEARCHERS WARN ANTIPSYCHOTIC DRUG MIGHT BE LINKED TO DIABETES
DURHAM, N.C. Research from Duke University Medical Center suggests there might be a link between at least one drug used to treat schizophrenia and the onset of diabetes, a disease widely recognized as one of the leading causes of death and disability in the U.S.
The drug, olanzapine (trade name Zyprexa), belongs to a relatively new family of medications called atypical antipsychotics, which are used to treat schizophrenia, paranoia and manic-depressive disorders. Other drugs in this class include clozapine, risperidone, quetiapine and ziprasidone.
The researchers found metabolic abnormalities ranging from mild blood sugar problems to diabetic ketoacidosis and coma in patients who had been prescribed olanzapine, most of whom were otherwise not known to be diabetic. Diabetic ketoacidosis (DKA) is a serious condition in which a person experiences an extreme rise in blood glucose level coupled with a severe lack of insulin, which results in symptoms such as nausea, vomiting, stomach pain and rapid breathing. Untreated, DKA can lead to coma and even death.
"While our report does not prove a causal relationship between the drug and diabetes, doctors should be aware of such potentially adverse effects," said P. Murali Doraiswamy, M.D., a psychiatrist at Duke and co-author of the study. "We've found cases where patients had some very serious problems associated with olanzapine, and at least 23 of them died."
The findings appear in the July 2, 2002 issue of Pharmacotherapy. The research was self-supported by the authors.
Doraiswamy and Elizabeth A. Koller, M.D., lead author of the study and a medical officer at the FDA, queried the FDA MedWatch Drug Surveillance System, MEDLINE (a biomedical database) and selected abstracts from national psychiatry meetings over a period of eight years and identified 289 cases of diabetes in patients who had been given olanzapine. Of the 289 cases of diabetes linked to the use of olanzapine, 225 were newly diagnosed cases. One hundred patients developed ketosis (a serious complication of diabetes), and 22 people developed pancreatitis, or inflammation of the pancreas, which is a life-threatening condition. There were 23 deaths, including that of a 15-year-old adolescent who died of necrotizing pancreatitis, a condition where the pancreas breaks down and dies. Most cases (71 percent) occurred within six months of starting the drug and many cases were associated with moderate weight gain.
"The average age of adults showing signs of diabetes after taking olanzapine was about 10 years younger than what is generally seen in the community," said Doraiswamy. "The younger age at onset plus the number of serious complications and the improvements reported when the drug was stopped all suggest a link to the disease. However, until we know if there are risk differences among drugs in this class, it is important for physicians to watch all patients receiving this medication for signs of diabetes so that it can be detected quickly and managed."
The study merely suggests an association between the drug and diabetes, said Doraiswamy. Further studies are needed to offer more conclusive evidence of a direct causal relationship. If future studies confirm the findings, he said that perhaps the FDA should consider including a stronger warning label for these drugs.
"The numbers are still sketchy since many adverse reactions are not reported to the FDA and we don't have a good handle on how many people have actually received these drugs," he cautioned. "Atypical antipsychotics can be life saving medications, but we need to learn more about their long-term side-effects. I think this should be a high priority for investigation."
Doraiswamy was part of a team from Duke that first reported a link between the antipsychotic drug clozapine and the development of diabetes in a 1994 issue of the American Journal of Psychiatry. Last year, Koller reported in the American Journal of Medicine that the FDA had received 384 reports of diabetes associated with the drug clozapine. According to the researchers, many cases of diabetes have also been reported with other antipsychotic drugs.
Doraiswamy has previously received funding and consulting fees from all companies that currently manufacture antipsychotic medications, including Eli Lilly and Company, the manufacturer of Zyprexa.
Posted by Denise528 on September 24, 2002, at 3:13:37
In reply to Diabetes, posted by hawkeye on September 23, 2002, at 18:59:51
Hello,
I asked my psychiatrist about Zyprexa and diabetes and his response is that because I wastn't putting on any weight from it then I wastn't at risk. Is he right, is it the weight increase (caused by Zyprexa) that results in Diabetes or is it the Zyprexa itself?
Denise
Posted by cybercafe on September 26, 2002, at 23:32:45
In reply to Diabetes, posted by hawkeye on September 23, 2002, at 18:59:51
I havn't got diabetes from my Zyprexa -- should I ask for my money back?
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