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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 11 of 11. This is the beginning of the thread.
Posted by bornunderabadsign on January 13, 2002, at 22:47:47
Gentlemen,
As my adderall has long stopped working, my doctor and I have decided upon the remarkable remedy suggested on this board, viz., antagonism of NMDA receptors in hopes of resetting glutameric activity by methlyated amantadine. I have been on Memantine HCL for two days now: yesterday approx. 50mg, and today 10mg qid.
Though I am not sure from what, I've been experiencing the most profound 'spaciness' and cognitive impairment, though whetether from the Adderall or memantine I'm uncertain.
I seem to recall that confusion is often a transient side-effect of Memantine? If not this, than a residual hyper-glutameric state from the stimulants? If not that, then could an anti-cholinergic condition be manifesting, possibly exacerbated by 60mg once daily prozac. I know acetylchlorinergic-'ase' activity is invloved in glutamate signalling.
I must apologive for my incoherent matching of paragraphs, but how long, in your experiences, has memantine taken to become efficacious? Not much is known about the metabolism or removal of NMDA transmitter in the brain, could it be that the residual levels of glutamate transmitter, consequenced by the Adderall, pass by diffusion and require more time than actilvely catabolized neurotransmitter? (eg. COMT & MAOI) Also, should stimulants be taken during the memantine trial, or abstained from?
Thanks so much for the help!
-James
Posted by JohnX2 on January 13, 2002, at 23:00:56
In reply to Memantine Confusion: JohnL and/or AndrewB-, posted by bornunderabadsign on January 13, 2002, at 22:47:47
I'll give you a freebee since I banned myself from this
board.I got the german pdr translated to english.
I think you probably just dosed it too fast it
is just making you dizzy.I think 10 mg TID may do the trick. And the
dizzyniss should subside. You may want to start
with 10 mg BID if the dizziness is really bad.But the side effect is definately memantine.
If you want the english pdr, contact the
american company ntii. www.ntii.com.
they will send you a translation.
Although it sounds like you are german.good luck.
let us know how it goes.
-john
> Gentlemen,
>
> As my adderall has long stopped working, my doctor and I have decided upon the remarkable remedy suggested on this board, viz., antagonism of NMDA receptors in hopes of resetting glutameric activity by methlyated amantadine. I have been on Memantine HCL for two days now: yesterday approx. 50mg, and today 10mg qid.
>
> Though I am not sure from what, I've been experiencing the most profound 'spaciness' and cognitive impairment, though whetether from the Adderall or memantine I'm uncertain.
>
> I seem to recall that confusion is often a transient side-effect of Memantine? If not this, than a residual hyper-glutameric state from the stimulants? If not that, then could an anti-cholinergic condition be manifesting, possibly exacerbated by 60mg once daily prozac. I know acetylchlorinergic-'ase' activity is invloved in glutamate signalling.
>
> I must apologive for my incoherent matching of paragraphs, but how long, in your experiences, has memantine taken to become efficacious? Not much is known about the metabolism or removal of NMDA transmitter in the brain, could it be that the residual levels of glutamate transmitter, consequenced by the Adderall, pass by diffusion and require more time than actilvely catabolized neurotransmitter? (eg. COMT & MAOI) Also, should stimulants be taken during the memantine trial, or abstained from?
>
> Thanks so much for the help!
>
> -James
Posted by bornunderabadsign on January 13, 2002, at 23:31:38
In reply to Re: Memantine Confusion: JohnL and/or AndrewB- » bornunderabadsign, posted by JohnX2 on January 13, 2002, at 23:00:56
>
> I'll give you a freebee since I banned myself from this
> board.
>
> I got the german pdr translated to english.
>
> I think you probably just dosed it too fast it
> is just making you dizzy.
>
> I think 10 mg TID may do the trick. And the
> dizzyniss should subside. You may want to start
> with 10 mg BID if the dizziness is really bad.
>
> But the side effect is definately memantine.
>
> If you want the english pdr, contact the
> american company ntii. www.ntii.com.
> they will send you a translation.
> Although it sounds like you are german.
>
> good luck.
>
> let us know how it goes.
>
> -john
>
Yes, thank you! I will look at the PDR and try the 10 three times daily. My first day, yesterday, on the Memantine I did not feel a difference with the adderall. Commonly, does it take a few days?Thanks very much again!
-James
Posted by JohnX2 on January 14, 2002, at 1:31:30
In reply to Re: Memantine Confusion: JohnL and/or AndrewB-, posted by bornunderabadsign on January 13, 2002, at 23:31:38
I don't have the exact pdr in front of
me I just remember 10 mg TID being a typical
dosing and I remember the titration being
pretty slow over a couple weeks.
So, I don't know how long it will take.
I have the doc packed away in a box.How long does the adderall take to poop out?
3-4 days?Maybe you should start the memantine for 1 week
while not on Adderall and then restart the
Adderall (i.e. take an Adderall vacation just
to clear up your system). I am by no means an
expert at this.If you contact NTII they probably can even
FAX you the english translated PDR. They are
very nice people. Otherwise, they will mail you
the PDR.regards,
john
> >
> > I'll give you a freebee since I banned myself from this
> > board.
> >
> > I got the german pdr translated to english.
> >
> > I think you probably just dosed it too fast it
> > is just making you dizzy.
> >
> > I think 10 mg TID may do the trick. And the
> > dizzyniss should subside. You may want to start
> > with 10 mg BID if the dizziness is really bad.
> >
> > But the side effect is definately memantine.
> >
> > If you want the english pdr, contact the
> > american company ntii. www.ntii.com.
> > they will send you a translation.
> > Although it sounds like you are german.
> >
> > good luck.
> >
> > let us know how it goes.
> >
> > -john
> >
> Yes, thank you! I will look at the PDR and try the 10 three times daily. My first day, yesterday, on the Memantine I did not feel a difference with the adderall. Commonly, does it take a few days?
>
> Thanks very much again!
>
> -James
Posted by Jodeye on April 5, 2002, at 21:56:56
In reply to Re: Memantine Confusion: JohnL and/or AndrewB-, posted by bornunderabadsign on January 13, 2002, at 23:31:38
> Yes, thank you! I will look at the PDR and try the 10 three times daily. My first day, yesterday, on the Memantine I did not feel a difference with the adderall. Commonly, does it take a few days?
>
> Thanks very much again!
>
> -James
James,How has the memantine/Adderall combination worked for you? I'm just waiting, waiting, waiting for this to work for someone after AndrewB. I have never tried Adderall or memantine, but if I was convinced they might work together, my U.S. doctor would probably prescribe them without question. Thanks.
--Jodeye
Posted by JohnX2 on April 6, 2002, at 15:39:41
In reply to Re: Memantine Confusion: JohnL and/or AndrewB- » bornunderabadsign, posted by Jodeye on April 5, 2002, at 21:56:56
> > Yes, thank you! I will look at the PDR and try the 10 three times daily. My first day, yesterday, on the Memantine I did not feel a difference with the adderall. Commonly, does it take a few days?
> >
> > Thanks very much again!
> >
> > -James
>
>
> James,
>
> How has the memantine/Adderall combination worked for you? I'm just waiting, waiting, waiting for this to work for someone after AndrewB. I have never tried Adderall or memantine, but if I was convinced they might work together, my U.S. doctor would probably prescribe them without question. Thanks.
>
> --Jodeye
I think at best you'll ever hear is anecdotal evidence of this medicine being useful for ampetamine tolerance. The jury is still out frankly. People may feel more comfortable prescribing it off-label after it gets official clinical approval for other indications in the US, but I doubt you'll ever see official human clinical data to the amphetamine tolerance issue (boy wouldn't a lot of people sign up for that clinical trial!). There is research data from lab rats....John
Posted by Jodeye on April 6, 2002, at 17:38:47
In reply to Re: Memantine Confusion: JohnL and/or AndrewB- » Jodeye, posted by JohnX2 on April 6, 2002, at 15:39:41
> I think at best you'll ever hear is anecdotal evidence of this medicine being useful for ampetamine tolerance. The jury is still out frankly. People may feel more comfortable prescribing it off-label after it gets official clinical approval for other indications in the US, but I doubt you'll ever see official human clinical data to the amphetamine tolerance issue (boy wouldn't a lot of people sign up for that clinical trial!). There is research data from lab rats....
>
> JohnHi John,
I am on the edge of my seat! AndrewB and James both stopped posting shortly after starting a memantine/Adderall trial. Were they arrested, are they institutionalized, deceased, completely cured?
By the way, I am 45, live with mom, and unemployed. I am looking for anything that might help with high-functioning autism. The most relevant conditions mentioned on this board would be avoidant personality or generalized social phobia (along with fatigue). I haven't tried many medications. I currently take 10mg fluoxetine which reduces my startle response and irritability level, and 50mg amisulpride which helps very little (but consistently) with social functioning. Still very tired.
Later,
--Jodeye
Aloha, Oregon
Posted by JohnX2 on April 6, 2002, at 23:23:56
In reply to Re: Memantine Confusion: JohnL and/or AndrewB-, posted by Jodeye on April 6, 2002, at 17:38:47
> > I think at best you'll ever hear is anecdotal evidence of this medicine being useful for ampetamine tolerance. The jury is still out frankly. People may feel more comfortable prescribing it off-label after it gets official clinical approval for other indications in the US, but I doubt you'll ever see official human clinical data to the amphetamine tolerance issue (boy wouldn't a lot of people sign up for that clinical trial!). There is research data from lab rats....
> >
> > John
>
> Hi John,
>
> I am on the edge of my seat! AndrewB and James both stopped posting shortly after starting a memantine/Adderall trial. Were they arrested, are they institutionalized, deceased, completely cured?
>
> By the way, I am 45, live with mom, and unemployed. I am looking for anything that might help with high-functioning autism. The most relevant conditions mentioned on this board would be avoidant personality or generalized social phobia (along with fatigue). I haven't tried many medications. I currently take 10mg fluoxetine which reduces my startle response and irritability level, and 50mg amisulpride which helps very little (but consistently) with social functioning. Still very tired.
>
> Later,
>
> --Jodeye
>
> Aloha, OregonJust curious,
Has your doctor prescribed stimulants for you in the past, and if so what has been the outcome?
Regards,
John
Posted by Jodeye on April 7, 2002, at 16:05:32
In reply to Re: Memantine Confusion: JohnL and/or AndrewB- » Jodeye, posted by JohnX2 on April 6, 2002, at 23:23:56
> > Just curious,
>
> Has your doctor prescribed stimulants for you in the past, and if so what has been the outcome?
>
> Regards,
> JohnHi,
33 years ago I tried biphetamine which I had to discontinue due to anxiety and hair loss. It really jolted me out of my state of mutism though. I'm not sure how biphetamine compares to todays stimulants.
I guess what I really want to know is what *tidbit* prompted AndrewB to ask his doctor for a trial of memantine to prevent Adderall tolerance.
--Jodeye
Posted by Hollywood Jerry on April 7, 2002, at 18:47:26
In reply to Re: Memantine Confusion: JohnL and/or AndrewB- » JohnX2, posted by Jodeye on April 7, 2002, at 16:05:32
> > > Just curious,
> >
> > Has your doctor prescribed stimulants for you in the past, and if so what has been the outcome?
> >
> > Regards,
> > John
>
> Hi,
>
> 33 years ago I tried biphetamine which I had to discontinue due to anxiety and hair loss. It really jolted me out of my state of mutism though. I'm not sure how biphetamine compares to todays stimulants.
>
> I guess what I really want to know is what *tidbit* prompted AndrewB to ask his doctor for a trial of memantine to prevent Adderall tolerance.
>
> --JodeyeI don't want to take words from his mouth, but from discussions with him, he was taking the memantine before taking Adderall for its other medicinal values (neuroprotection, etc). He had mentioned that in the past he couldn't tolerate Adderall because of poop-out. When it came to light that the memantine may help with amphetamine tolerance, he restarted the Adderall and found that Adderall (amphetamine salts) no longer "pooped-out". This was my understanding.
John
Posted by JohnX2 on April 7, 2002, at 18:55:50
In reply to Re: Memantine Confusion: JohnL and/or AndrewB- » Jodeye, posted by Hollywood Jerry on April 7, 2002, at 18:47:26
This is most definately odd.John
> > > > Just curious,
> > >
> > > Has your doctor prescribed stimulants for you in the past, and if so what has been the outcome?
> > >
> > > Regards,
> > > John
> >
> > Hi,
> >
> > 33 years ago I tried biphetamine which I had to discontinue due to anxiety and hair loss. It really jolted me out of my state of mutism though. I'm not sure how biphetamine compares to todays stimulants.
> >
> > I guess what I really want to know is what *tidbit* prompted AndrewB to ask his doctor for a trial of memantine to prevent Adderall tolerance.
> >
> > --Jodeye
>
> I don't want to take words from his mouth, but from discussions with him, he was taking the memantine before taking Adderall for its other medicinal values (neuroprotection, etc). He had mentioned that in the past he couldn't tolerate Adderall because of poop-out. When it came to light that the memantine may help with amphetamine tolerance, he restarted the Adderall and found that Adderall (amphetamine salts) no longer "pooped-out". This was my understanding.
>
> John
This is the end of the thread.
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