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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 6 of 6. This is the beginning of the thread.
Posted by christophrejmc on December 4, 2001, at 0:54:08
Has anyone had success with adding any other med(s) to Parnate (tranylcypromine)? It seems that lithium and T3 augmentation are the only "standard" options available. Is there any increased risk when adding amphetamine to Parnate as opposed to Nardil? Thanks.
Christophre.
Posted by Elizabeth on December 8, 2001, at 0:21:21
In reply to Parnate polypharmacy, posted by christophrejmc on December 4, 2001, at 0:54:08
> Is there any increased risk when adding amphetamine to Parnate as opposed to Nardil? Thanks.
There probably is, but there have certainly been people who've tolerated the combination. Methamphetamine (Desoxyn) probably is safer in terms of cardiovascular side effects, but doctors tend not to want to prescribe it.
-elizabeth
Posted by christophrejmc on December 8, 2001, at 1:31:55
In reply to Re: Parnate polypharmacy, posted by Elizabeth on December 8, 2001, at 0:21:21
Thanks! I've been prescribed Adderall, Dexadrine, and Ritalin many times in the past for ADD symptoms but I really fear bringing up methamphetamine (especially because I was planning to discuss Ultram with my pdoc next session).
> There probably is, but there have certainly been people who've tolerated the combination. Methamphetamine (Desoxyn) probably is safer in terms of cardiovascular side effects, but doctors tend not to want to prescribe it.
>
> -elizabeth
Posted by Elizabeth on December 8, 2001, at 7:40:24
In reply to Re: Parnate polypharmacy, posted by christophrejmc on December 8, 2001, at 1:31:55
Well, the thing about Desoxyn is, it has more central action relative to peripheral -- IOW, at a dose that will work for your ADD, you will get less cardiovascular side effects than you would with Dexedrine. So it's probably safest of the stronger stimulants (Provigil is pretty safe with Parnate, but it's really weak). Still, I know that many people have taken, and had great success with, combinations of MAOIs with other stimulants (Dexedrine, Adderall, Ritalin, Cylert, Provigil).
-elizabeth
Posted by psydoc on December 9, 2001, at 22:36:00
In reply to Parnate polypharmacy, posted by christophrejmc on December 4, 2001, at 0:54:08
> Has anyone had success with adding any other med(s) to Parnate (tranylcypromine)? It seems that lithium and T3 augmentation are the only "standard" options available. Is there any increased risk when adding amphetamine to Parnate as opposed to Nardil? Thanks.
>
> Christophre.MAOIs can be used with many drugs that are normally considered contraindicated. Among those are psychostimulants such as dexedrine, Ritalin and Provigil. The antidepressant Wellbutrin has also been combined with MAOIs. See:
Pierre JM, Gitlin MJ.
Bupropion-tranylcypromine combination for treatment-refractory depression.
J Clin Psychiatry. 2000 Jun;61(6):450-1.Best regards . . .
Ivan
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Posted by Elizabeth on December 10, 2001, at 10:25:56
In reply to Re: Parnate polypharmacy, posted by psydoc on December 9, 2001, at 22:36:00
> The antidepressant Wellbutrin has also been combined with MAOIs.
I've actually heard of a few people using Wellbutrin with MAOIs, and although it doesn't seem to be an especially popular combination, I've never heard of a bad reaction (or seen one reported in the literature). I think the combination is probably fairly safe. Some people can't tolerate combinations of MAOIs with stimulants because of hypertension or because of excessive jitteriness.
-elizabeth
This is the end of the thread.
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