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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 7 of 7. This is the beginning of the thread.
Posted by Collette on November 4, 2001, at 9:14:22
I have been on Geodon for 5 weeks ( along with Prozac which I have taken for many years) and I have been on a diet for 5 weeks also. It's a low-calorie, low carb diet and I get on my Nordic track about 5 days a week as well. I HAVEN'T BEEN ABLE TO DROP EVEN ONE POUND!
Does anyone think there is some sort of connection? Oh I have also been taking Trazodone for about 3 weeks also. Thanks! Collette
Posted by Cam W. on November 4, 2001, at 13:06:14
In reply to No weight gain with Geodon...BUT!, posted by Collette on November 4, 2001, at 9:14:22
Collette - I recently attended a schizophrenia conference where one of the presenters, a reknown researcher and clinician (at least in our area) Dr.Pierre Chue, said that he felt that, like EPS and tardive dyskinesia with the older antipsychotics/neuroleptics, that weight gain "may" be an irreversible side effect effect of the atypical antipsychotics.
When I brought up the lack of weight gain with ziprasidone (Geodon™) and quetiapine (Seroquel™), he said that (as I already knew) Seroquel "does" cause weight gain on the average of Risperdal™ (risperidone) and that Geodon may not cause weight gain, but it isn't a very effective antipsychotic either.
A few years ago I heard Dr.Bill Wirshing (from UCLA, I believe) speak on weight gain and atypical antipsychotics. His take on it, at least back then, was that the more potent and powerful an atypical antipsychotic was, the more toxic it was. I still use his line, "Clozaril, a highly toxic drug; the best antipsychotic we have; Seroquel, a very, very safe drug; it doesn't work, but it is a very safe drug."
I have since found that Seroquel does have some efficacy in cases where the psychosis is mild and not florid, and Clozaril™ (clozapine) isn't really as toxic as we once thought (as long as we respect it's power).
Now, getting back to weight gain with atypical antipsychotics being irreversible. From what I have witnessed over the past few years, this may be true. I brought this subject up with my pdoc and he made the statement that EPS and TD may not be so bad, in light of all the collerateral problems (hypertension, hyperglycemia, increased mortality, etc.) associated with weight gain.
I think that it is high time that researchers and companies start pouring serious money into these potential problems. You really can't blame the drug companies, as seeing the these problems as irreversible only manifest themselves after the drugs have been on the market for a considerable length of time.
Something to ponder - Cam
Posted by Collette on November 4, 2001, at 13:49:06
In reply to Re: No weight gain with Geodon...BUT! » Collette, posted by Cam W. on November 4, 2001, at 13:06:14
> Collette - I recently attended a schizophrenia conference where one of the presenters, a reknown researcher and clinician (at least in our area) Dr.Pierre Chue, said that he felt that, like EPS and tardive dyskinesia with the older antipsychotics/neuroleptics, that weight gain "may" be an irreversible side effect effect of the atypical antipsychotics.
>
>
> I have since found that Seroquel does have some efficacy in cases where the psychosis is mild and not florid, and Clozaril™ (clozapine) isn't really as toxic as we once thought (as long as we respect it's power).
>
> Now, getting back to weight gain with atypical antipsychotics being irreversible. From what I have witnessed over the past few years, this may be true. I brought this subject up with my pdoc and he made the statement that EPS and TD may not be so bad, in light of all the collerateral problems (hypertension, hyperglycemia, increased mortality, etc.) associated with weight gain.
>
> I think that it is high time that researchers and companies start pouring serious money into these potential problems. You really can't blame the drug companies, as seeing the these problems as irreversible only manifest themselves after the drugs have been on the market for a considerable length of time.
>
> Something to ponder - CamAre you saying that the weight that I have gained from the Zyprexa CAN'T be lost?? That sounds almost impossible ( although it is what I am experienceing) I thought that perhaps the Geodon was somehow preventing weight loss. thanks you for your response, collette
Posted by Cam W. on November 4, 2001, at 15:22:08
In reply to Re: No weight gain with Geodon...BUT! » Cam W., posted by Collette on November 4, 2001, at 13:49:06
Collette - Not being able to shed Zyprexa-induced weight gain is what a majority of people are saying. I am not saying to give up, but I am saying that what Dr.Chue has said does give one pause for thought. I'd like to hear from those who were able to get back to a baseline weight (ie. the weight they were before starting Zyprexa). - Cam
Posted by Karen Curtis on November 4, 2001, at 16:40:17
In reply to Re: No weight gain with Geodon...BUT! » Collette, posted by Cam W. on November 4, 2001, at 13:06:14
> Collette - I recently attended a schizophrenia conference where one of the presenters, a reknown researcher and clinician (at least in our area) Dr.Pierre Chue, said that he felt that, like EPS and tardive dyskinesia with the older antipsychotics/neuroleptics, that weight gain "may" be an irreversible side effect effect of the atypical antipsychotics.
>
> When I brought up the lack of weight gain with ziprasidone (Geodon™) and quetiapine (Seroquel™), he said that (as I already knew) Seroquel "does" cause weight gain on the average of Risperdal™ (risperidone) and that Geodon may not cause weight gain, but it isn't a very effective antipsychotic either.
>
> A few years ago I heard Dr.Bill Wirshing (from UCLA, I believe) speak on weight gain and atypical antipsychotics. His take on it, at least back then, was that the more potent and powerful an atypical antipsychotic was, the more toxic it was. I still use his line, "Clozaril, a highly toxic drug; the best antipsychotic we have; Seroquel, a very, very safe drug; it doesn't work, but it is a very safe drug."
>
> I have since found that Seroquel does have some efficacy in cases where the psychosis is mild and not florid, and Clozaril™ (clozapine) isn't really as toxic as we once thought (as long as we respect it's power).
>
> Now, getting back to weight gain with atypical antipsychotics being irreversible. From what I have witnessed over the past few years, this may be true. I brought this subject up with my pdoc and he made the statement that EPS and TD may not be so bad, in light of all the collerateral problems (hypertension, hyperglycemia, increased mortality, etc.) associated with weight gain.
>
> I think that it is high time that researchers and companies start pouring serious money into these potential problems. You really can't blame the drug companies, as seeing the these problems as irreversible only manifest themselves after the drugs have been on the market for a considerable length of time.
>
> Something to ponder - CamCam- my pdoc said that below a certain dosage, geodon tends to do nothing. He seems to think that dosage should be no less than 120mg. ? Thoughts- my son is on 160mg of geodon and some added seroquel- holding off on the great clozaril for now!! Karen Curtis
Posted by Cam W. on November 4, 2001, at 21:41:17
In reply to Re: No weight gain with Geodon...BUT! To Cam, posted by Karen Curtis on November 4, 2001, at 16:40:17
Karen - I have no clinical experience with Geodon, as it has not been released in Canada. Others on this board would know better if it works at higher dosages rather than lower. I'd be interested to know if this is true, as well. - Cam
Posted by Karen Curtis on November 5, 2001, at 16:35:41
In reply to Re: No weight gain with Geodon...BUT! To Cam » Karen Curtis, posted by Cam W. on November 4, 2001, at 21:41:17
> Karen - I have no clinical experience with Geodon, as it has not been released in Canada. Others on this board would know better if it works at higher dosages rather than lower. I'd be interested to know if this is true, as well. - Cam
I will post that question then! I was born in Windsor, Ontario, and still visit Quebec and Toronto to see relatives! Wish I could visit more of Canada- Karen
This is the end of the thread.
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