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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 6 of 6. This is the beginning of the thread.
Posted by SalArmy4me on July 16, 2001, at 2:19:04
Table 3.8 {From Professor and Chair of UKansas Dr. Preskorn's of Columns on Psychopharmacology}
http://www.preskorn.com/cgi-bin/sp.pl?words=clomipramine&wt=be&bl=an&d=/books/ssri_s3.html
explains how fluoxetine and sertraline have a clinically relevant effect on noradrenalin (thus norepinephrine).
Posted by Janelle on July 16, 2001, at 14:35:12
In reply to The Answer to the SSRI Selectivity Question, posted by SalArmy4me on July 16, 2001, at 2:19:04
If I'm not mistaken, fluxetine (spelling, sorry) is Prozac and sertraline is Zoloft? I'd also add that paroxetine (which is Paxil) also affects Norepinephrine. I bet a few other so-called SSRI's also do. However, only the manufacturer of EffexorXR thus far pushed to be recognized "officially" as working on norephinephrine.
Posted by Bob on July 16, 2001, at 16:40:18
In reply to The Answer to the SSRI Selectivity Question, posted by SalArmy4me on July 16, 2001, at 2:19:04
> Table 3.8 {From Professor and Chair of UKansas Dr. Preskorn's of Columns on Psychopharmacology}
> http://www.preskorn.com/cgi-bin/sp.pl?words=clomipramine&wt=be&bl=an&d=/books/ssri_s3.html
> explains how fluoxetine and sertraline have a clinically relevant effect on noradrenalin (thus norepinephrine).If the levels of norepinephrine re-uptake that is present with the typical SSRI is considered "clinically significant", then why is it that the typical response to them for many people is the development of a drive-deficient state, to which noradrenergic enhancing drugs are suggested as a solution? Interestingly, the study did not include Venlaflaxine, in comparison to the other SSRIs so that the relative levels of norepinephrine could be seen. I'm assuming it's higher with Effexor?
Posted by SalArmy4me on July 16, 2001, at 17:08:07
In reply to Re: The Answer to the SSRI Selectivity Question, posted by Bob on July 16, 2001, at 16:40:18
I think the drive-deficient state is either due to the depletion of dopamine over time with SSRI's.
Posted by bob on July 16, 2001, at 20:10:14
In reply to Re: The Answer to the SSRI Selectivity Question, posted by SalArmy4me on July 16, 2001, at 17:08:07
> I think the drive-deficient state is either due to the depletion of dopamine over time with SSRI's.
You used the work "either", but only mentioned the depletion of dopamine. Is there another substance you were going to suggest, or just dopamine?
Why is it thought that dopamine is depleted over time?
If dopamine depletion is indeed the case, than what would the ideal solution be? Isn't Welbutrin a dopamine agonist? I don't see evidence of many people augmenting SSRIs with Welbutrin.
I was always under the impression that there was a more or less proven link between goal-oriented behavior and norepinephrine.
Posted by Mitch on July 17, 2001, at 11:14:32
In reply to Re: The Answer to the SSRI Selectivity Question, posted by SalArmy4me on July 16, 2001, at 17:08:07
Sal,
Do you have any more detailed info on how SSRI administration depletes dopamine? I am curious personally because the more "selective" SSRI's tend to cause dystonias for me. Given that, I wonder if I should continue taking them. I am also hypersensitive to EPS with AP's as well.
Mitch
> I think the drive-deficient state is either due to the depletion of dopamine over time with SSRI's.
This is the end of the thread.
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