Psycho-Babble Medication Thread 64139

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Wellbutrin and Ecstasy

Posted by Thomas Allen Brown on May 24, 2001, at 14:14:55

I am wondering if anyone has had experience with wellbutrin (200mg/day) and ecstasy. I know it is a stupid thing, but i may try it and would like to know if i will have a seizure and possibly die. Thank you.

 

Re: Wellbutrin and Ecstasy

Posted by Phil on May 24, 2001, at 20:45:22

In reply to Wellbutrin and Ecstasy, posted by Thomas Allen Brown on May 24, 2001, at 14:14:55

"I know it is a stupid thing,"


You may have answered your own question. Every time I am about do something and I hear this little voice in me head saying,"This is really stupid." I, more often than not, should have listened.
My $.02.

 

Re: Wellbutrin and Ecstasy

Posted by Elizabeth on May 24, 2001, at 21:52:19

In reply to Wellbutrin and Ecstasy, posted by Thomas Allen Brown on May 24, 2001, at 14:14:55

> I am wondering if anyone has had experience with wellbutrin (200mg/day) and ecstasy. I know it is a stupid thing, but i may try it and would like to know if i will have a seizure and possibly die. Thank you.

No experience here, but an interaction is unlikely. Wellbutrin is not a serotonergic drug, nor does it lower the seizure threshold significantly in the dose range that is used clinically (especially if you take Wellbutrin SR). If you're intent on trying MDMA and you're still worried about seizures, you could stop the Wellbutrin a couple days before taking the ecstasy, and wait a day or two before starting it again.

-elizabeth

 

Re: Wellbutrin and Ecstasy Thomas Allen Brown

Posted by SalArmy4me on May 25, 2001, at 13:32:40

In reply to Wellbutrin and Ecstasy, posted by Thomas Allen Brown on May 24, 2001, at 14:14:55

Ecstasy use with Wellbutrin is safe--if you disregard the mountain full of scientific evidence that proves that Ecstasy causes depression:

1: Bailly D. Related Articles
[Neuropsychiatric disorders induced by MDMA ("Ecstasy")].
Encephale. 1999 Nov-Dec;25(6):595-602.

2: Henry JA.
Ecstasy and serotonin depletion.
Lancet. 1996 Mar 23;347(9004):833.

3: Pennings EJ, Konijn KZ, de Wolff FA. [Clinical and toxicologic aspects of the use of Ecstasy].
Ned Tijdschr Geneeskd. 1998 Aug 29;142(35):1942-6. Review. Dutch.

4: Gerra G, Zaimovic A, Giucastro G, Maestri D, Monica C, Sartori R, Caccavari R, Delsignore R. Related Articles
Serotonergic function altered after (+/-)3,4-methylene-dioxymethamphetamine ('Ecstasy') in humans.
Int Clin Psychopharmacol. 1998 Jan;13(1):1-9.

5: Liberg JP, Hovda KE, Nordby G, Jacobsen D. Related Articles
[Ecstasy--long-lasting effects]?
Tidsskr Nor Laegeforen. 1998 Nov 20;118(28):4384-
7. Norwegian.

6: Schifano F, Di Furia L, Forza G, Minicuci N, Bricolo R. Related Articles
MDMA ('ecstasy') consumption in the context of polydrug abuse: a report on 150 patients.
Drug Alcohol Depend. 1998 Sep 1;52(1):85-90.

7: Parrott AC, Lasky J. Related Articles
Ecstasy (MDMA) effects upon mood and cognition: before, during and after a Saturday night dance.
Psychopharmacology (Berl). 1998 Oct;139(3):261-8.

8: Zhou FC, Tao-Cheng JH, Segu L, Patel T, Wang Y. Related Articles
Serotonin transporters affected by MDMA are located on the axons beyond the synaptic junctions: anatomical and functional evidence.
Brain Res. 1998 Sep 14;805(1-2):241-54.

9: Curran HV, Travill RA. Related Articles
Mood and cognitive effects of +/-3,4-methylenedioxymethamphetamine (MDMA, 'ecstasy').
Addiction. 1997 Jul;92(7):821-31.

10: Yau JL, Noble J, Seckl JR. Related Articles
Site-specific regulation of corticosteroid and serotonin receptor subtype gene expression in the rat hippocampus following 3,4-MDMA: role of corticosterone and serotonin.
Neuroscience. 1997 May;78(1):111-21.

11: Miller RT, Lau SS, Monks TJ.
2,5-Bis-(glutathion-S-yl)-alpha-methyldopamine, a putative metabolite of (+/-)-3,4-methylenedioxyamphetamine (MDMA), decreases brain serotonin concentrations.
Eur J Pharmacol. 1997 Apr 4;323(2-3):173-80.

12: White SR, Obradovic T, Imel KM, Wheaton MJ. Related Articles
The effects of methylenedioxymethamphetamine (MDMA, "Ecstasy") on monoaminergic neurotransmission in the central nervous system.
Prog Neurobiol. 1996 Aug;49(5):455-79. Review.

13: Immunomodulating activity of MDMA
Ann N Y Acad Sci. 2000;914:215-24.

14: Pacifici R, Zuccaro P, Shannon, M.
Methylenedioxymethamphetamine (MDMA, "Ecstasy").
Pediatr Emerg Care. 2000 Oct;16(5):377-80.

15: Nielsen JC, Nicholson K, Pitzner-Jorgensen BL, Unden M. Related Articles
[Abuse of Ecstasy (3,4-methylenedioxymethamphetamine). Pharmacological, neuropsychiatric and behavioral aspects].
Ugeskr Laeger. 1995 Feb 6;157(6):724-7. Review. Danish.

16: McGuire PK, Cope H, Fahy TA.
Diversity of psychopathology associated with use of 3,4-methylenedioxymethamphetamine ('Ecstasy')
Br J Psychiatry. 1994 Sep;165(3):391-5.

17: Riedlinger TJ, Riedlinger JE.
Psychedelic and entactogenic drugs in the exacerbation of depression.
J Psychoactive Drugs. 1994 Jan-Mar;26(1):41-55. Review.

18: Peroutka SJ, Newman H, Harris H.
Subjective effects of 3,4-methylenedioxymethamphetamine in recreational users. Neuropsychopharmacology. 1988 Dec;1(4):273-

19: Schmidt CJ, Taylor VL. Related Articles
Depression of rat brain tryptophan hydroxylase activity following the acute administration of methylenedioxymethamphetamine (MDMA).
Biochem Pharmacol. 1987 Dec 1;36(23):4095-102.

20: Steele TD, Nichols DE, Yim GK. Related Articles
Stereochemical effects of 3,4-methylenedioxymethamphetamine (MDMA) and related amphetamine derivatives on inhibition of uptake of [3H]monoamines into synaptosomes from different regions of rat brain.
Biochem Pharmacol. 1987 Jul 15;36(14):2297-303.

21: Frith CH, Chang LW, Lattin DL, Walls RC, Hamm J, Doblin R.
Toxicity of methylenedioxymethamphetamine (MDMA) in the dog and the rat.
Fundam Appl Toxicol. 1987 Jul;9(1):110-9.

22: Gibb JW, Stone DM, Stahl DC, Hanson GR.
The effects of amphetamine-like designer drugs on monoaminergic systems in the brain.
NIDA Res Monogr. 1987;76:316-21.

23: Stone DM, Stahl DC, Hanson GR, Gibb JW.
The effects of 3,4-methylenedioxymethamphetamine (MDMA) and 3,4-methylenedioxyamphetamine (MDA) on monoaminergic systems in the rat brain.
Eur J Pharmacol. 1986 Aug 22;128(1-2):41-8.

24: Schifano, F.
Human neurotoxicity of MDMA ('Ecstasy'): subjective self-reports, evidence from an Italian drug addiction centre and clinical case studies.
Neuropsychobiology. 2000;42(1):25-33. Review.

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