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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 21 of 21. This is the beginning of the thread.
Posted by Mr. Scott on March 11, 2001, at 1:07:40
Does anyone know what the status of the selegiline Transdermal Patch is? Is it ever going to be available? Has anyone used it with any success?
Posted by Lorraine on March 13, 2001, at 9:55:21
In reply to Selegilene Transdermal Patch, posted by Mr. Scott on March 11, 2001, at 1:07:40
Scott: I searched the web high and low and no info on this. I'm interested too as I take 10 mg/day.
Posted by Mr. Scott on March 13, 2001, at 11:40:54
In reply to Re: Selegilene Transdermal Patch, posted by Lorraine on March 13, 2001, at 9:55:21
> Scott: I searched the web high and low and no info on this. I'm interested too as I take 10 mg/day.
I contacted Sommerset Pharamaceuticals and they told me the patch for depression is still in Phase 3 clinical trials, and Phase 2 clinical trials for ADHD, Smoking cessation, and Alzheimers disease. But that doesn't mean a patch won't be available sooner for it's original indication (parkinsons disease). I am intersted in what your experience has been with this drug, why it's being prescribed to you, side effects, and all that good stuff. I am about to begin taking it for Atypical depression.. My doc is Gung Ho about it, but no one else seems to know much about it or how well it works.. I'm always a little scared when I start a new med especially one without an indication for what it is being prescribed for, so anything you can tell me about your experience will be much appreciated. :)
Posted by Lorraine on March 13, 2001, at 13:53:19
In reply to Re: Selegilene Transdermal Patch, posted by Mr. Scott on March 13, 2001, at 11:40:54
Selegiline is a wonderful drug. It is written up in Smart Drugs and Smart Drugs II (books avail. at Amazon.com or your local library). It is being using in Alzheimer's as a neuroprotective, neurorescue and possibly neurorestorative action. It significantly extended the life of rats (I don't know that that translates to humans tho). It is a puppy uppper and converts to amphetamine in the liver. You can take up to 15 mg a day without dietary restrictions. Above 15 mg it is a non-selective MAO with the "cheese effect" potential and dietary restrictions apply. I was put on it because I am treatment resistant and we are trying to find an MAO effect without the dietary restrictions. I started on 5 mg a day (2.5 2x day) and am now at 10 mg a day. I am taking it with Neurontin, which is an anticonvulsant and anti-anxiety drug. I really would like to see Selegiline work because I believe that the drug is actually good for you in addition to helping with depression. Good luck. Let me know how it goes.
Posted by Lorraine on March 13, 2001, at 14:23:15
In reply to Re: Selegilene Transdermal Patch, posted by Mr. Scott on March 13, 2001, at 11:40:54
Here are some links with info for you:
http://www.smart-drugs.net/ias-deprenyl.htm
http://www.deprenyl.net/#L-deprenyl plus L-phenylalanine in the treatment of depression
http://www.dr-bob.org/babble/19991212/msgs/17103.html
I have an article entitled "Pharmacology of selegiline" by Gerlach (1996, Neurology Vol. 47, no. 6)
Posted by roo on March 13, 2001, at 16:18:35
In reply to Re: Selegilene Transdermal Patch, posted by Lorraine on March 13, 2001, at 14:23:15
Lorraine,
Did you get the positive sexual side effects I've
heard a couple of people rave about? If so, tell
me more, and sign me up.
Posted by Lorraine on March 13, 2001, at 18:30:51
In reply to Re: Selegilene Transdermal Patch, posted by roo on March 13, 2001, at 16:18:35
> Yes I did when I took it alone. Now I'm taking it with Neurontin. I'll let you know which side wins the war after the battle. LOL
Posted by Mr. Scott on March 13, 2001, at 18:39:14
In reply to Re: Selegilene Transdermal Patch, posted by Lorraine on March 13, 2001, at 14:23:15
> Here are some links with info for you:
>
> http://www.smart-drugs.net/ias-deprenyl.htm
>
> http://www.deprenyl.net/#L-deprenyl plus L-phenylalanine in the treatment of depression
>
> http://www.dr-bob.org/babble/19991212/msgs/17103.html
>
> I have an article entitled "Pharmacology of selegiline" by Gerlach (1996, Neurology Vol. 47, no. 6)Hey thanks!! keep me posted on your outcome.
Posted by Mr. Scott on March 13, 2001, at 18:43:33
In reply to Re: Selegilene Transdermal Patch, posted by roo on March 13, 2001, at 16:18:35
> Lorraine,
>
> Did you get the positive sexual side effects I've
> heard a couple of people rave about? If so, tell
> me more, and sign me up.Roo, It is definately stimulating the sex drive..but I'm only on my first day after being on Zoloft (killer of all libidos) for a long time. I feel like an adolescent in that regard.. Hope it also works for Depression/Anxiety..
Posted by Mr. Scott on March 13, 2001, at 18:58:22
In reply to Re: Selegilene Transdermal Patch Scott, posted by Lorraine on March 13, 2001, at 13:53:19
> Selegiline is a wonderful drug. It is written up in Smart Drugs and Smart Drugs II (books avail. at Amazon.com or your local library). It is being using in Alzheimer's as a neuroprotective, neurorescue and possibly neurorestorative action. It significantly extended the life of rats (I don't know that that translates to humans tho). It is a puppy uppper and converts to amphetamine in the liver. You can take up to 15 mg a day without dietary restrictions. Above 15 mg it is a non-selective MAO with the "cheese effect" potential and dietary restrictions apply. I was put on it because I am treatment resistant and we are trying to find an MAO effect without the dietary restrictions. I started on 5 mg a day (2.5 2x day) and am now at 10 mg a day. I am taking it with Neurontin, which is an anticonvulsant and anti-anxiety drug. I really would like to see Selegiline work because I believe that the drug is actually good for you in addition to helping with depression. Good luck. Let me know how it goes.
One other thing.. How is the neurontin working to control the Stimulating feeling the sel produces? I am taking trazodone with it to help but I don't like trazodone much
Posted by Lorraine on March 13, 2001, at 19:24:20
In reply to Re: Selegilene Transdermal Patch Scott, posted by Mr. Scott on March 13, 2001, at 18:58:22
>
> One other thing.. How is the neurontin working to control the Stimulating feeling the sel produces? I am taking trazodone with it to help but I don't like trazodone muchI hated trazodone. The neurontin is being titrated up so I'm not in a steady state yet. My anxiety (which is only physical and existed before the Selegiline) is not gone. I'll know in a couple of days. I also suspect the Neurontin is making me dumb, but maybe I'm just not on an even keel yet.
Posted by roo on March 14, 2001, at 9:22:35
In reply to Re: Selegilene Transdermal Patch, posted by Lorraine on March 13, 2001, at 18:30:51
You'll probably be fine. I didn't get any sexual
side effects from neurotin until I boosted it up
to 1800 mg's. And I also take prozac, which probably
made it worse. I wanna try some of this dang
selegiline. Guess I'll I have to drop the prozac
though, which will probably be fine, b/c I'm starting
to suspect that I could be okay on a mood stabilizer
alone. Not quite as great, but probably good enough,
which is good enough for me in order to have a sex life
again.
Posted by roo on March 14, 2001, at 9:34:11
In reply to Re: Selegilene Transdermal Patch, posted by roo on March 13, 2001, at 16:18:35
> Lorraine,
ps. did you have any trouble sleeping on selegiline?
Posted by Lorraine on March 14, 2001, at 9:34:19
In reply to Re: Selegilene Transdermal Patch, posted by roo on March 14, 2001, at 9:22:35
> Neurontin is supposed to give mood support--AD--as well as mood stabilizing and anti-anxiety effects. Mood support is what I am wrestling with now. I am moving up to the 900 mg mark on Neurontin.
Posted by Lorraine on March 14, 2001, at 10:47:20
In reply to Re: Selegilene Transdermal-lorraine, posted by roo on March 14, 2001, at 9:34:11
> > Lorraine,
> ps. did you have any trouble sleeping on selegiline?I take Neurontin with it so at night that brings me down. No doubt it is a puppy upper. If the Neurontin wasn't sufficient, I'd take GABA--a natural enzyme that really is quite good for getting to sleep when you need to. My pdoc says you can take up to 1500 mg GABA a day. I was taking 1000 mg at night when I was on stimulating drugs. You should always check with your pdoc before adding in something like GABA though because it does effect the brain chemistry substantially. I also found GABA good for mild anxiety.
Posted by roo on March 14, 2001, at 11:17:04
In reply to Re: Selegilene Transdermal-Roo, posted by Lorraine on March 14, 2001, at 10:47:20
What is GABA? Is it a prescribed drug or something
you get at health stores?
Posted by steve on March 15, 2001, at 2:53:02
In reply to Re: Selegilene Transdermal Patch, posted by roo on March 13, 2001, at 16:18:35
> Lorraine,
>
> Did you get the positive sexual side effects I've
> heard a couple of people rave about? If so, tell
> me more, and sign me up.Diogenes was my hero, and I try to emulate him on this site.
Treating depression is a great idea, and usually the benefits outweigh the side-effects.
However I feel I should point out to you that if you are taking selegine to boost your bedroom performance, you are taking a medicine with a mode of action identical to that of that all natural South American herbal product cocaine ie dopamine reuptake, which, one would presume, would also have share cocaine's downsides, like neurotoxicity, withdrawal, etc.
S.
Posted by Lorraine on March 15, 2001, at 9:54:17
In reply to Re: Selegilene Transdermal Patch, posted by steve on March 15, 2001, at 2:53:02
S. : I'm not taking Selegiline for its bedtime performance. I'm taking it because it is a selective MAO inhibitor, meaning I get the benefits of an MAO inhibitor without the dietary restrictions. Selegiline actually is a neuroprotective and neurorestorative agent. So I'm feeling lucky as long as I can stay on it. It extends the life of rats. It is not like cocaine, although it metabolizes into methamphetamine, the belief is that that is not its main mode of action. No doubt though that it is a puppy upper. Do a search on Medline if you want some info about it. It is a very interesting drug.
Posted by Lorraine on March 15, 2001, at 9:54:45
In reply to Re: Selegilene Transdermal-lorraine, posted by roo on March 14, 2001, at 11:17:04
GABA is an enzyme. You get it at a health food store.
Posted by steve on March 15, 2001, at 14:06:55
In reply to Re: Selegilene Transdermal Patch, posted by Lorraine on March 15, 2001, at 9:54:17
> S. : I'm not taking Selegiline for its bedtime performance. I'm taking it because it is a selective MAO inhibitor, meaning I get the benefits of an MAO inhibitor without the dietary restrictions. Selegiline actually is a neuroprotective and neurorestorative agent. So I'm feeling lucky as long as I can stay on it. It extends the life of rats. It is not like cocaine, although it metabolizes into methamphetamine, the belief is that that is not its main mode of action. No doubt though that it is a puppy upper. Do a search on Medline if you want some info about it. It is a very interesting drug.
You wouldn't happen to have references for it's being a neuroprotective and expanding longetivity would you?
I've heard the same thing, but on the other hand, I've also heard McEwen, the designer of tianeptine report that tianeptine is a neuroprotective in the hippocampus due to its acceleration of 5ht reuptake. Now to me it seems that either slowing or accelerating 5ht reuptake will avoid cell death, but I don't see how both will. I also notice how commericial interests are much more likely to report the "neuroprotective" effects of what they are peddling than any (significant) neurotoxicity. So which is it?
S.
Posted by Lorraine on March 15, 2001, at 20:26:26
In reply to Re: Selegilene Transdermal Patch, posted by steve on March 15, 2001, at 14:06:55
Here are some links with info for you:
http://www.smart-drugs.net/ias-deprenyl.htmhttp://www.deprenyl.net/#L-deprenyl plus L-phenylalanine in the treatment of depression
http://www.dr-bob.org/babble/19991212/msgs/17103.html
I have an article entitled "Pharmacology of selegiline" by Gerlach (1996, Neurology Vol. 47, no. 6)
The best one and most serious is the last article mentioned above. I do not have a link for it. Here's some more on point tho:
J Neural Transm Suppl 1998;52:109-23
Selegiline delays the onset of disability in de novo parkinsonian patients.
Magyar K, Szende B, Lengyel J, Tarczali J, Szatmary I
Department of Pharmacodynamics, Semmelweis University of Medicine, Budapest, Hungary.The pharmacological effects of (-)-deprenyl is multi-fold in its nature (dopamine sparing activity, neuroprotective and neuronal rescue effects), which cannot be explained solely by the irreversible MAO-B inhibitory action of the substance. Deprenyl slightly inhibits the re-uptake of noradrenaline and dopamine, but methylamphetamine, the metabolite of the inhibitor, by one order of magnitude is more potent in this respect, than the parent compound. Neither the metabolite nor (-)-deprenyl acts on the uptake of serotonin. The inhibitor has an intensive first pass metabolism after oral treatment. The in vivo pharmacokinetic studies with (-)-deprenyl, using the double labelled radioisotope technique (1.5 mg/kg; orally) in rats revealed that the molar concentration of methylamphetamine can reach the level suitable to induce a significant inhibition of amine uptake. Deprenyl, but especially methylamphetamine pre-treatment can prevent the noradrenaline release induced by the noradrenergic neurotoxin DSP-4. The uptake inhibitory effect of (-)-deprenyl and the metabolites is reversible. After repeated administration of (-)-deprenyl (1.5 mg/kg daily, for 8 days) sustained concentration of its metabolites was detected, compared to that of the acute studies. This can at least partly explain why (-)deprenyl should be administered daily to evoke therapeutic effects in Parkinson's disease. Administration of (-)-deprenyl in a low dose, following the toxic insult, can rescue the damaged neurones. The neuronal rescue effect of the drug was studied on M-1 human melanoma cells in tissue culture. The inhibitor reduced the apoptosis of serum-deprived M-1 cells, but the (+)-isomer failed to exert this effect. The (+/-)-desmethyl-deprenyl almost lacks the property to inhibit apoptosis. For neuroprotection and neuronal rescue an optimal dose of (-)-deprenyl should be administered, because to reach a well balanced concentration of the metabolites in tissues is critical.
Publication Types:
Review
Review, tutorial
PMID: 9564614, UI: 98225801
Still I agree that we are more likely to see studies about the good than the bad with drugs.
This is the end of the thread.
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