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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 3 of 3. This is the beginning of the thread.
Posted by PhoenixGirl on November 28, 2000, at 11:53:13
Does anyone know which chemical imipramine has a greater effect on -- noradrenaline or serotonin?
Posted by SLS on November 28, 2000, at 21:31:26
In reply to Does Imipramine do more for noradr. or serotonin?, posted by PhoenixGirl on November 28, 2000, at 11:53:13
> Does anyone know which chemical imipramine has a greater effect on -- noradrenaline or serotonin?
Hi PhoenixGirl.= > Arise from the ashes?
Most of the tricyclic antidepressants are more potent reuptake inhibitors of norepinephrine (noradranaline) than they are of serotonin. Imipramine falls into this category. Clomipramine (Anafranil), and possibly amitriptyline (Elavil), display some potency of the reuptake inhibition of serotonin. In fact, clomipramine produces some side effects known to be common with the SSRIs (selective serotonin reuptake inhibitors), including anorgasmia.Imipramine is metabolized by the body into desipramine. During therapy, the blood levels of desipramine are far higher than those of the parent compound, imipramine. Desipramine is the most selective reuptake inhibitor of norepinephrine among the tricyclics. It is similar to reboxetine in this regard.
- Scott
Posted by PhoenixGirl on November 29, 2000, at 14:50:51
In reply to Re: Does Imipramine do more for noradr. or serotonin?, posted by SLS on November 28, 2000, at 21:31:26
Hello Scott. Yes, you guessed the meaning of my name. :-)
Thank you for all that very helpful information! I was wondering, because I have had a lot of sexual dysfunction on the strongly serotonergic antidepressants, but I remember not having too much of a problem on imipramine, which I took years ago. I've just recently begun the transition from my current AD (Remeron) to desipramine, because even remeron causes the sexual dysfunction. (Though not as badly as most of the serotonergic ADs). Some people report sexual dysfunction with the more noradrenergic ADs, which I don't understand because I thought that increasing serotonin was the cause. Thoughts?
People have such varied responses to ADs, but what is your experience with sexual function on ADs?
PhoenixGirl
> Does anyone know which chemical imipramine has a greater effect on -- noradrenaline or serotonin?
>
>
> Hi PhoenixGirl.
>
> = > Arise from the ashes?
>
>
> Most of the tricyclic antidepressants are more potent reuptake inhibitors of norepinephrine (noradranaline) than they are of serotonin. Imipramine falls into this category. Clomipramine (Anafranil), and possibly amitriptyline (Elavil), display some potency of the reuptake inhibition of serotonin. In fact, clomipramine produces some side effects known to be common with the SSRIs (selective serotonin reuptake inhibitors), including anorgasmia.
>
> Imipramine is metabolized by the body into desipramine. During therapy, the blood levels of desipramine are far higher than those of the parent compound, imipramine. Desipramine is the most selective reuptake inhibitor of norepinephrine among the tricyclics. It is similar to reboxetine in this regard.
>
>
> - Scott
This is the end of the thread.
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