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Dr. Bob is Robert Hsiung, MD,
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Posted by ruth on May 26, 2000, at 12:47:05
Hi,
I've been on a combo of prozac and disipramine for
about 7 months now. I was on 75 mg's of disipramine
and 20 mg's of prozac. I grew tired of the side effects
of the TCA and also found it didn't prevent me from
falling into a major depression about 5 months ago(that's
when we added the prozac which helped the depression,
and with the disipramine, had a stronger effect).
Anyway, I'm titrating down from the disipramine slowly--
under my doc's care. I've been taking 50 mg's for
the last 3 weeks, and soon i'll be taking 25 mg's for
one month, and then nothing.
I'm not sure if it's my imagination or not, but I feel
a low grade irritability and frustration and anxiety...
could this be caused by the lower dosage? Is it likely
I'll adjust after awhile?
Thanks in advance for any responses--Ruth
Posted by Cam W. on May 27, 2000, at 22:43:49
In reply to weaning off TCA/Disipramine, posted by ruth on May 26, 2000, at 12:47:05
Ruth - The irritiability, frustration and anxiety could be due to your body reacting to life without the desipramine (a readjustment of receptors due to losing the desipramine effect on them). Desipramine is a TCA with mainly norepineprhrine reuptake blocking actions, so if it didn't make a difference in your depression, your depression may be serotonergically based. The weaning from desipramine is a good idea, but not everyone needs to do it. Give it a week or two more and your side effects should go away. Inform your doc on how you feel.Hope this helps - Cam
This is the end of the thread.
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