![[dr. bob]](/dr-bob-sm.gif)
Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 5 of 5. This is the beginning of the thread.
Posted by Will on April 16, 2000, at 16:01:04
Can anybody share their experiences with Amoxapine?
I pulled up a recent medline search that stated that this med, in lower doses, was actually quite comparable to many of the new atypical antipsychotics,
while attaining a good antidepressant-antianxiety effect.I had strong hopes for Nefadazone, and it's 5-ht2 downregulation, as it is suspected that is one of the receptor types that play a part in not only the nasty sexual side effects of SSRI's, but also in messing up the sleep pattern. After five months use at up to max dose, it made me very tired, lethargic, and miserable.
Thanks
Will
Posted by george o on April 16, 2000, at 16:38:25
In reply to Amoxapine , posted by Will on April 16, 2000, at 16:01:04
> Can anybody share their experiences with Amoxapine?
> I pulled up a recent medline search that stated that this med, in lower doses, was actually quite comparable to many of the new atypical antipsychotics,
> while attaining a good antidepressant-antianxiety effect.
>
> I had strong hopes for Nefadazone, and it's 5-ht2 downregulation, as it is suspected that is one of the receptor types that play a part in not only the nasty sexual side effects of SSRI's, but also in messing up the sleep pattern. After five months use at up to max dose, it made me very tired, lethargic, and miserable.
>
> Thanks
>
> Willamoxapine is really nasty stuff, made me emotional weak dizzy constipated. almost no docs prescribe it because patients almost never do well on it, atypical antipsychotics are generally easier to take and have a better effect, i take seroquel because it has very few side effects. george
Posted by Will on April 16, 2000, at 21:30:55
In reply to don't believe everything you read, posted by george o on April 16, 2000, at 16:38:25
> > Can anybody share their experiences with Amoxapine?
> > I pulled up a recent medline search that stated that this med, in lower doses, was actually quite comparable to many of the new atypical antipsychotics,
> > while attaining a good antidepressant-antianxiety effect.
> >
> > I had strong hopes for Nefadazone, and it's 5-ht2 downregulation, as it is suspected that is one of the receptor types that play a part in not only the nasty sexual side effects of SSRI's, but also in messing up the sleep pattern. After five months use at up to max dose, it made me very tired, lethargic, and miserable.
> >
> > Thanks
> >
> > Will
>
> amoxapine is really nasty stuff, made me emotional weak dizzy constipated. almost no docs prescribe it because patients almost never do well on it, atypical antipsychotics are generally easier to take and have a better effect, i take seroquel because it has very few side effects. george
---
Thanks George...you most likely saved me some nasty experiences:-)Will
Posted by Scott L. Schofield on April 17, 2000, at 10:05:20
In reply to Re: don't believe everything you read, posted by Will on April 16, 2000, at 21:30:55
> > > Can anybody share their experiences with Amoxapine?
> > > I pulled up a recent medline search that stated that this med, in lower doses, was actually quite comparable to many of the new atypical antipsychotics,
> > > while attaining a good antidepressant-antianxiety effect.
> > >
> > > I had strong hopes for Nefadazone, and it's 5-ht2 downregulation, as it is suspected that is one of the receptor types that play a part in not only the nasty sexual side effects of SSRI's, but also in messing up the sleep pattern. After five months use at up to max dose, it made me very tired, lethargic, and miserable.
> > >
> > > Thanks
> > >
> > > Will
> >
> > amoxapine is really nasty stuff, made me emotional weak dizzy constipated. almost no docs prescribe it because patients almost never do well on it, atypical antipsychotics are generally easier to take and have a better effect, i take seroquel because it has very few side effects. george
> ---
> Thanks George...you most likely saved me some nasty experiences:-)
>
> Will
----------------------------------------
Dear Will,If you haven't tried one of the newer neuroleptics such as Zyprexa, Seroquel, or possibly Risperdal, you may want to consider this approach first. There is nothing I am aware of that would prevent you from combining one of these drugs with an antidepressant. I feel that a stubborn effort towards finding a successful treatment through monotherapy is often counterproductive.
I am not advocating you use it, but...
Amoxapine (Asendin) certainly does work as an antidepressant. I have seen several posts here in which the poster described a wonderful response to it when they had failed to respond to other drugs. I tried it once, and don't remember it as having anticholinergic side effects that were any worse than some of the other tricyclics.
I am not sure why amoxapine has gone into disfavor by clinicians when the use of a tricyclic has been decided upon. I can think of a few reasons why it should, but they are not related to efficacy.
* George, what other tricyclics have you tried?
I myself had a bad experience with amoxapine. It exacerbated my depression. It sounds like George experienced something similar with his description of emotional weakness. I attribute this to the ability of amoxapine to antagonize (block) dopamine (DA) receptors. Herein may lie the pharmacological basis for the clinical information you found.
Amoxapine is a derivative of loxapine (Loxitane), an antipsychotic that blocks DA receptors, a property shared by both typical and atypical neuroleptic antipsychotics. Amoxapine does block DA receptors. Because of this, amoxapine shares with these other drugs the potential for producing extrapyramidal side effects (EPS), including such things as dyskinesia, dysphasia, akathisia, and the more malignant tardive-dyskinisia. Tardive-dyskinesia is an irreversible syndrome of uncontrollable movements.
I know for sure that amoxapine has caused EPS in some people. This was evident even in the pilot studies, but was swept under the rug. It probably should never have made it to market. However, I imagine those people who have posted descriptions of their success with amoxapine would intensely disagree with this position.
It is important to take into consideration that many people have used amoxapine for a long time without having any of these side effects appear. I'm sure there are also those who, like some other users of tricyclics, do not experience significantly untoward side effects at all.
I would guess that this has probably confused the issue a bit, but I thought you should know all of the facts that I am aware of.
Good luck.
- Scott
Posted by Anna P. on April 17, 2000, at 15:29:20
In reply to don't believe everything you read, posted by george o on April 16, 2000, at 16:38:25
> >
>
> George, what happened with Tianeptine, as I remember?Anna P.
This is the end of the thread.
Psycho-Babble Medication | Extras | FAQ
Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.org
Script revised: February 4, 2008
URL: http://www.dr-bob.org/cgi-bin/pb/mget.pl
Copyright 2006-17 Robert Hsiung.
Owned and operated by Dr. Bob LLC and not the University of Chicago.