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Dr. Bob is Robert Hsiung, MD,
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Posted by mark on March 2, 2000, at 12:08:04
does anyone know about the history of clozapine,
like who discovered the drug and the date of discovery?
And does anyone know what the discoverers had originally
intended it's use to be? I am doing a research project on
clozapine, and am finding it very difficult to come upon
this information. Any help would be greatly appreciated!
Posted by kelly on March 2, 2000, at 15:31:29
In reply to question about clozapine..., posted by mark on March 2, 2000, at 12:08:04
> does anyone know about the history of clozapine,
> like who discovered the drug and the date of discovery?
> And does anyone know what the discoverers had originally
> intended it's use to be? I am doing a research project on
> clozapine, and am finding it very difficult to come upon
> this information. Any help would be greatly appreciated!
Phenothiazines,were discovered by accident.
In the early 1950s a french surgeon, Henri laborit,used a drug in this chemical family, thorazine(chlorpromazine) to try to reduce blood pressure in patients before surgery.He found that their blood pressure didn't drop, but that they became much less anxious.French psychiatrists tried the drug w/ their patients, & found that it worked.It also reduced hallucinations & delusions among schizophrenic patients.Chemists quickly analyed chlorpromazine & developed many others drugs that are related to it but are even more effective in reducing psychotic symptoms(e.g.,clozapine,haloperidol)
Posted by Cam W. on March 4, 2000, at 13:31:56
In reply to question about clozapine..., posted by mark on March 2, 2000, at 12:08:04
> does anyone know about the history of clozapine,
> like who discovered the drug and the date of discovery?
> And does anyone know what the discoverers had originally
> intended it's use to be? I am doing a research project on
> clozapine, and am finding it very difficult to come upon
> this information. Any help would be greatly appreciated!
Mark - Here are a few studies you can look up in your nearest medical library:Hippius H. A historical perspective of clozapine.
J Clin Psychiatry. 1999;60 Suppl 12:22-23.Kerwin RW. Clozapine: back to the future for schizophrenia research. Lancet. 1995 Apr29;
345(8957): 1063-1064.Hippius H. The history of clozapine.
Psychopharmacology (Berl). 1989;99 Suppl: S3-S5.
Good luck - Cam W.
This is the end of the thread.
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