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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 5 of 5. This is the beginning of the thread.
Posted by PL on November 15, 1999, at 15:54:20
Site
http://www.lycaeum.org/drugs/SSRI/
Posted by dj on November 16, 1999, at 12:23:43
In reply to An Interesting View of SSRIs Can Be Found At This , posted by PL on November 15, 1999, at 15:54:20
I'd be curious to see what a few of the more chemically astute members of this forum have to say about the anonymous authors comparism of
Fluvoxamine (which I have NO idea what it's trade or common name is...) vs Fluoxetine (Prozac). I've quoted a passage from the cited url below and am curious to see some comments on the assertations made below and ther validity..."Fluvoxamine was the FIRST successful specific serotonine-reuptake-blocker(SSRI)to stand the test of time.
Fluvoxamine is a Duphar product.
Fluvoxamine is a TYPICAL serotonine-reuptake-blocker,as opposed to fluoxetine which is an atypical serotonine-reuptake-blocker.
Typical and atypical SSRIs are distinguished by the following properties:
Typical:
1.Induce sleep. 2.Reduce the number of spontaneous thoughts per unit of time(this is called a "pro-attenuation" effect). 3.Reduce headaches or general flu-like pains. 4.Reduce reactions to stress by induction of placidity and emotional indifference. 5.Suppress recalls of dreams. 6.Suppress rapidly moral pain associated to depression and suicidal ideation. 7.Reduce aggressivity.
Fluvoxamine is the prototype of the typical SSRIs.
Typical SSRIs are thought to act by diminishing dopaminergic neurotransmission via serotoninergic mechanisms.
Atypical:
1.Induce insomnia. 2.Induce headaches. 3.Can stimulate aggressivity. 4.Increase dream recalls. 5.Induce subhallucinations in darkness.Fluoxetine is the prototype of an atypical SSRI.
Fluoxetine is thought to act by increasing dopaminergic neurotransmission via indirect stimulation of serotoninergic 5-HT2A receptors.
In a way,fluoxetine is a very mild hallucinogen.
The typical SSRI Fluvoxamine can suppress the unwanted side-effects of Fluoxetine..."
Posted by Adam on November 16, 1999, at 15:27:54
In reply to Interesting indeed but.., posted by dj on November 16, 1999, at 12:23:43
Fluvoxamine is the generic name for Luvox.
I've never heard of this "typical vs. atypical" SSRI catagorization. They're all rather different chemically
and rather similar in action and efficacy. It seems the primary differences between them that are of any
clinical importance are side effects.An excellent chapter on the subject of newer antidepressants, which describes some of the similarities and
differences between SSRIs can be found here:http://www.medscape.com/PCI/depression/depression.ch06/depression.ch06-01.html
See especially Table 6.1.
Access to Mescape is free, you just need to register.
I found particularly interesting (and inexplicable) the statement that fluoxetine is a "very mild hallucinogen."
Where on earth did that come from? I've heard that Ambien and SSRIs in combination have led to hallucinations
in some instances. I think delerium of one form or another is a very rare side-effect of a number of antidepressants.
> I'd be curious to see what a few of the more chemically astute members of this forum have to say about the anonymous authors comparism of
> Fluvoxamine (which I have NO idea what it's trade or common name is...) vs Fluoxetine (Prozac). I've quoted a passage from the cited url below and am curious to see some comments on the assertations made below and ther validity...
>
> "Fluvoxamine was the FIRST successful specific serotonine-reuptake-blocker(SSRI)to stand the test of time.
>
> Fluvoxamine is a Duphar product.
>
> Fluvoxamine is a TYPICAL serotonine-reuptake-blocker,as opposed to fluoxetine which is an atypical serotonine-reuptake-blocker.
>
> Typical and atypical SSRIs are distinguished by the following properties:
>
> Typical:
>
> 1.Induce sleep. 2.Reduce the number of spontaneous thoughts per unit of time(this is called a "pro-attenuation" effect). 3.Reduce headaches or general flu-like pains. 4.Reduce reactions to stress by induction of placidity and emotional indifference. 5.Suppress recalls of dreams. 6.Suppress rapidly moral pain associated to depression and suicidal ideation. 7.Reduce aggressivity.
>
> Fluvoxamine is the prototype of the typical SSRIs.
>
> Typical SSRIs are thought to act by diminishing dopaminergic neurotransmission via serotoninergic mechanisms.
>
> Atypical:
>
>
> 1.Induce insomnia. 2.Induce headaches. 3.Can stimulate aggressivity. 4.Increase dream recalls. 5.Induce subhallucinations in darkness.
>
> Fluoxetine is the prototype of an atypical SSRI.
>
> Fluoxetine is thought to act by increasing dopaminergic neurotransmission via indirect stimulation of serotoninergic 5-HT2A receptors.
>
> In a way,fluoxetine is a very mild hallucinogen.
>
> The typical SSRI Fluvoxamine can suppress the unwanted side-effects of Fluoxetine..."
Posted by Luisa on November 16, 1999, at 17:51:03
In reply to Re: Interesting indeed but.., posted by Adam on November 16, 1999, at 15:27:54
> Fluvoxamine is the generic name for Luvox.
>Also under brand name of Faverin in UK
Posted by Louisa on November 17, 1999, at 15:14:35
In reply to Re: Interesting indeed but.., posted by Luisa on November 16, 1999, at 17:51:03
You might want to have a look at the main page for that site. The compilers appear to have a fair bit of experience with hallucinogens, but perhaps not so much with depression.
Louisa
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