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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 24 of 24. This is the beginning of the thread.
Posted by SandraDee on October 1, 2002, at 9:44:18
Gabbi Gabbi? I haven't even heard from her in an email for a few days now. Suppose she's out partying it up over the weekend, without us? Hmmph.
Posted by SandraDee on October 1, 2002, at 11:15:40
In reply to Good to see Beardy back, but where is..., posted by SandraDee on October 1, 2002, at 9:44:18
Posted by tina on October 1, 2002, at 12:30:45
In reply to And Tina too...? (nm), posted by SandraDee on October 1, 2002, at 11:15:40
Hey SandraDee
I'm hangin in there. Got some new meds and climbing out of the hole slowly. Don't know what to do with myself if/when I get out though. That's the part that usually shoves me back down to the bottom. The "why bother, there's nothing up there" thoughts. Just can't push those aside.
HOpe all is well with you Sandra. YOu're always so generous to think of others so often.
take care
tina
Posted by shar on October 1, 2002, at 13:33:00
In reply to Re: And Tina too...? » SandraDee, posted by tina on October 1, 2002, at 12:30:45
Glad to see you again. I understand completely about wondering what to do when you get to the top of the pit.
Sometimes I think it's just a matter of which is less awful. It always feels to me that, all things considered, the bottom of the pit is more awful than the top.
Hope all goes well with you.
Shar
Posted by Tabßitha on October 1, 2002, at 14:15:47
In reply to Good to see Beardy back, but where is..., posted by SandraDee on October 1, 2002, at 9:44:18
Gabbi Gabbi has gone silent. Maybe it's up to us to fill the void, how 'bout it, Sandi Sandi?
Tabbi Tabbi
Posted by Ted on October 1, 2002, at 14:33:12
In reply to Re: And Tina too...? » SandraDee, posted by tina on October 1, 2002, at 12:30:45
Hi Tina,
Good to hear you found the ladder down in the pit. Don't worry about climbing out -- we'll all give you a hand and show you around.
Take care and keep climbing, however slowly you must go.
ted
Posted by SandraDee on October 1, 2002, at 17:10:58
In reply to Re: And Tina too...? » SandraDee, posted by tina on October 1, 2002, at 12:30:45
It's definately not me being "generous" it's that you all have a little (okay - prepare for the sappiness) place in my heart and head or something. Even when I'm away from the stupid computer, I find myself wondering how some of you are doing. Weird to have friends that you don't see or talk to other than posting messages. I DO have other friends that I can call and stuff, but it's nice to have a little place that you know you don't get judged for feeling like a bad mom or feeling like you're worthless or even just feeling that the whole world is grey or black sometimes. Fortunately I'm seeing in color right now, but still have those muted color days. I think most of y'all can relate to that. :)
Good to hear you are okay. Drop a line occasionally and let us know your progress and stuff, will ya? Thanks.
Posted by SandraDee on October 1, 2002, at 17:24:17
In reply to It's not me! haha » tina, posted by SandraDee on October 1, 2002, at 17:10:58
I think about is... Phil with a baseball bat at the junkyard - when I drive past our local junkyard.
And you can't say I need a hobby, I've got one. Just that since I'm around little kids (3 and under) all day every day, I need some adult interaction I guess, soooo since most everyone I know here works during the day, I think about the PB People. Wonder if we can get Fisher Price to make up some PB Little People or something. Then they'd make a PB PsychWard, and the PB Transport Van and Plane so we could all get around.
Dang I need some adult interaction hahaha I need to not play with toys for a day or so!
Posted by Ginjoint on October 1, 2002, at 22:02:57
In reply to Another thing..., posted by SandraDee on October 1, 2002, at 17:24:17
Hi Sandra Dee...
I'm new here, but I wanted to tell you that your idea of the Fisher Price PB Little People gave me the first laugh I've had all day. Thanks!
I can see it...a PB Little Person with bloodshot eyes from insomnia...a PB LP with a tiny battery inside that causes it to shake, simulating Lithium tremors...a PB LP house, complete with empty refrigerator and a teeny tiny stack of unpaid bills...and I wonder what the PB LP psychiatrist's office would look like... ;)
Time for me to start to attempt sleep. Sandra Dee, I hope you find some energy for yourself. G'night....
Ginjoint
Posted by SandraDee on October 2, 2002, at 0:40:36
In reply to Re: Another thing... » SandraDee, posted by Ginjoint on October 1, 2002, at 22:02:57
I'm so glad someone else related to what I was trying to what I said. They could make a PB LP Dr. Bob that has a talk feature or something and when the button is pushed it'll say "Please be civil". Anyhow, Welcome to PB. :)
Posted by Ginjoint on October 2, 2002, at 8:12:01
In reply to Thank YOU » Ginjoint, posted by SandraDee on October 2, 2002, at 0:40:36
Posted by Gabbix2 on October 2, 2002, at 12:02:03
In reply to Thank YOU » Ginjoint, posted by SandraDee on October 2, 2002, at 0:40:36
It may be a little early for me to say this, but I think I love you.
That was so damn funny, and I needed that!
I need a little add-on trailer for my bills though. Maybe a cardboard box as my new home.Thank you.
Sandra Dee.. Shame on you for describing yourself so negatively. I had a completely different picture of what you looked like, simply by what you'd said.
You've got the sweetest sunshiny face, and the prettiest smile, you're absolutely vibrant.
Thanks you guys
Gabbi (lost in the funhouse)
Posted by SandraDee on October 2, 2002, at 12:08:09
In reply to Thank you Twice -Gin Joint -Sandra Dee., posted by Gabbix2 on October 2, 2002, at 12:02:03
Thanks a whole bunch. :) But I guess I don't have the rose colored picture you have. hahaha
GREAT to hear from you. Wishing you all the best... -Just me
Posted by Ted on October 2, 2002, at 12:44:16
In reply to Thank you Twice -Gin Joint -Sandra Dee., posted by Gabbix2 on October 2, 2002, at 12:02:03
Gabbi,
You're back! Great to hear from you again. Hope you are doing OK.
Ted
Posted by Gabbix2 on October 2, 2002, at 15:01:04
In reply to You're back!! » Gabbix2, posted by Ted on October 2, 2002, at 12:44:16
Hey,
Yeah, I'm back sort of.
Feeling hopeless and dreadfuland I did get a picture, except I was bored and I was playing with photoshop (bad idea)
I wanted to see what I would look like as a sea cucumber.
I looked pretty damn cute
But now I can't undo what I did and I have no other copy of my picture.So I'm trapped as a sea cucumber.
I wonder if I can regrow my brain now?
oh I guess they don't really have brains.
figures.
Posted by Gabbix2 on October 2, 2002, at 15:06:41
In reply to Re: You're back!! And as a sea cucumber., posted by Gabbix2 on October 2, 2002, at 15:01:04
I'm starting some medication called Manerix.
Can't get much info on it, as its only available in Canada.
Must be something pretty special.
Posted by alii on October 2, 2002, at 15:43:35
In reply to I have a dr.'s dissapointment today., posted by Gabbix2 on October 2, 2002, at 15:06:41
Gabbix2,
This is from this site: http://www.mentalhealth.com/fr30.html
Moclobemide
Brand name: Manerix
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Drug monograph
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Contents
Pharmacology
Indications
Contraindications
Precautions
Dosage
Supplied
Research
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Pharmacology
AntidepressantMoclobemide is a short-acting, reversible inhibitor of monoamine oxidase (MAO). It is a benzamide derivative which inhibits the deamination of serotonin, norepinephrine and dopamine. This action leads to increased concentrations of these neurotransmitters, which may account for the antidepressant activity of moclobemide.
MAOs are currently subclassified into 2 types, A and B, which differ in their substrate specificity. Moclobemide preferentially inhibits MAO-A; at a 300 mg dose, the inhibition of MAO-A is approximately 80%, while that of MAO-B is approximately 20 to 30%. The estimated MAO-A inhibition is short-lasting (maximum 24 hours) and reversible.
Drug Interactions:
Tyramine:
During studies conducted at the maximum recommended moclobemide dose of 600 mg/day, the mean dose of tyramine required to produce a 30 mm Hg increase in systolic blood pressure was 148 +/- 50 mg ( 76 to 200 mg) when moclobemide was administered immediately after tyramine. The threshold dose of tyramine was reduced to 84 +/- 23 mg (54 to 112 mg) when the sequence of administration was reversed so that moclobemide was administered 1 hour before tyramine. These findings indicate that the potentiation of tyramine may be minimized by administering moclobemide after, instead of prior to, a tyramine-enriched meal.Cimetidine:
In a drug interaction study, the concomitant administration of cimetidine and moclobemide led to the doubling of the area under the plasma concentration-time curve of moclobemide. Cimetidine therapy is expected to approximately double moclobemide steady-state concentrations.Pharmacokinetics:
Volunteers:
General:
Following oral administration, moclobemide was 98% absorbed from the gastrointestinal tract. Due to hepatic first pass effect, absolute bioavailability was approximately 55% after single doses, but 90% after multiple doses. The apparent volume of distribution was approximately 1.2 L/kg, indicating extensive tissue distribution.Moclobemide was extensively metabolized, 95% of the administered dose was excreted in the urine. The metabolites were pharmacologically inactive. Moclobemide was 50% bound to plasma proteins, mainly to albumin.
The presence of food reduced the rate, but not the extent of moclobemide absorption.
Single Dose:
Following the administration of a 100 mg single oral dose of moclobemide to healthy subjects, peak plasma concentrations ranged from 488 ng/mL to 1450 ng/mL (mean C(max): 849 ng/mL) and were reached in 0.5 to 3.5 hours (mean t(max): 49 min). The elimination half-life was 1.5 hours. Up to 200 mg, the pharmacokinetics of moclobemide were linear. At higher doses, non-linear pharmacokinetics were observed. In a dose range of 400 mg to 1200 mg, maximum plasma concentrations increased and clearance decreased in a non dose-proportional manner. With increasing doses, the elimination half-life also became prolonged.Multiple Dose:
During the second week of a 100 mg t.i.d. dosing regimen in healthy subjects, the steady-state trough concentrations of moclobemide ranged between 114 ng/mL and 517 ng/mL. An increase in the dose to 150 mg t.i.d. resulted in a greater than proportional increase in moclobemide steady-state trough concentrations, namely to concentrations ranging between 346 ng/mL and 1828 ng/mL.Patients:
Hepatic Impairment, Single Dose:
In patients with liver cirrhosis, the administration of a single 100 mg dose of moclobemide resulted in approximately a three-fold increase in peak plasma concentrations (C(max): 1607 ng/mL), and elimination half-life (t(1/2): 4 hr), while clearance decreased about 4 fold (CI 337 mL/min).Renal Impairment, Single Dose:
In patients with renal insufficiency, the administration of a single 100 mg dose of moclobemide did not appreciably alter the pharmacokinetics of the drug, except for an increase in absorption time.Elderly Patients, Single and Multiple Dose:
Following a 100 mg t.i.d. dosing regimen in elderly subjects (65 to 77 years old), C(max) and AUC values were somewhat higher than in young subjects (21 to 34 years old), namely 1498 versus 950 ng/mL and 5571 versus 3102 ng h/mL, respectively. Clearance in the elderly was reduced (19.7 versus 32.3 L/h).
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Indications
For the symptomatic relief of depressive illness.
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Contraindications
In patients with a known hypersensitivity to the drug. Moclobemide is also contraindicated in patients in an acute confusional state.
In a clinical study designed to test the interaction between moclobemide and a tricyclic antidepressant (clomipramine), severe adverse reactions emerged and the study was terminated. Data involving other tricyclic antidepressants is limited. Consequently, the concomitant use of moclobemide and tricyclic antidepressants is contraindicated.Clinical data are not available on the concomitant use of moclobemide and selective serotonin reuptake inhibitors or other available MAO inhibitors. Therefore, until such data becomes available, moclobemide should not be administered in combination with these agents.
There is no experience with the concomitant use of moclobemide and narcotics. However, death has occurred in patients receiving a nonreversible, nonselective MAO inhibitor and meperidine given concomitantly. Therefore, moclobemide should not be used in combination with meperidine.
Children:
As the safety and effectiveness of moclobemide in children below the age of 18 have not been established, pediatric use is not recommended.
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Precautions
General:
The possibility of suicide in depressed patients is inherent in their illness and may persist until remission occurs. Therefore, patients must be carefully supervised during all phases of treatment with moclobemide. Prescriptions in potentially suicidal patients should be written for a limited supply only.
Depressed patients in whom agitation is the predominant clinical symptom should not be treated with moclobemide.In patients with thyrotoxicosis or pheochromocytoma, conventional MAO inhibitors may precipitate a hypertensive reaction. Because there are no data available on the use of moclobemide in such patients, caution is advised when prescribing moclobemide to these subjects.
Occupational Hazards:
Patients should be cautioned against driving an automobile or performing hazardous tasks until they are certain of the effect that moclobemide has on them.Pregnancy:
Safety of use in pregnancy has not been established. Therefore, moclobemide is not recommended in women who may be pregnant, unless, in the opinion of the physician, the expected benefits to the patient markedly outweigh the possible risk to the fetus.Lactation:
Clinical data suggests that small quantities of moclobemide are excreted in human milk. Therefore, moclobemide is not recommended in nursing mothers unless the anticipated benefits outweigh the potential harm to the infant.Hepatic Dysfunction:
In patients with severe liver dysfunction, the daily dose of moclobemide should be substantially reduced to one-third or one-half of the standard dose (see Pharmacology).Renal Dysfunction:
Single dose pharmacokinetic data suggest that no dosage adjustment may be required in patients with impaired renal function (see Pharmacology). However, multiple dose studies with moclobemide have not been performed in patients with renal dysfunction, therefore, moclobemide should be used with caution in this patient population. In normal volunteers, the absolute bioavailability almost doubles following multiple dosing as compared to a single dose.Drug Interactions:
Cimetidine:
Cimetidine doubles the AUC (area under the plasma concentration-time curve) of moclobemide and is expected to approximately double moclobemide steady-state concentrations (see Pharmacology).In patients treated with cimetidine, it is recommended that moclobemide be initiated at the lowest recommended dose, i.e., 100 to 200 mg/day.
In patients treated with moclobemide, a 50% reduction in the dosage of moclobemide may be necessary before commencing cimetidine treatment.
Tyramine:
In a limited number of clinical pharmacology trials, the blood pressure increase observed during administration of moclobemide together with tyramine-enriched food was less than what would be expected after the administration of currently marketed MAO inhibitors.There is limited experience in patients who took moclobemide before meals. Most clinical trial protocols specified that the drug be taken immediately after meals. Therefore, patients should be instructed to take moclobemide immediately after meals (see Pharmacology).
Treatment with moclobemide does not necessitate the special dietary restrictions required for other available MAO inhibitors. However, until further studies are carried out, patients should be advised to avoid the consumption of excessive amounts of aged or overripe cheese and yeast extracts.
As an added safety measure, patients should be urged to report immediately the abrupt occurrence of any of the following symptoms; occipital headache, palpitations, neck stiffness, tachycardia or bradycardia or other atypical or unusual symptoms not previously experienced. Hypertensive patients should be cautioned to avoid excessive consumption of foods that are high in tyramine content.
Other Antidepressants:
Concomitant Use:
Clinical studies between moclobemide and a tricyclic antidepressant (clomipramine) resulted in severe adverse reactions (see Contraindications). Data involving other tricyclic antidepressants is limited. Therefore, the concomitant use of moclobemide and tricyclic antidepressants is contraindicated.Clinical data are not available on the concomitant use of moclobemide and selective serotonin re-uptake inhibitors, or other available MAO inhibitors. Therefore, until clinical data become available, moclobemide should not be administered in combination with these agents.
Sequential Use:
Treatment with a tricyclic antidepressant may be initiated following the discontinuation of moclobemide with a short washout period of no less than 2 days.When switching patients from serotonergic antidepressants to a conventional MAO inhibitor, it is standard practice to allow for a washout period equivalent to at least 4 to 5 half-lives of the previously administered drug or any active metabolites. This recommendation also applies to moclobemide.
Fluoxetine:
An exception is fluoxetine; at least 5 weeks should elapse between its discontinuation and initiation of treatment with moclobemide.Buspirone:
To date, there is no experience regarding the co-administration of moclobemide and buspirone. Therefore, patients should be carefully monitored should concomitant administration be implemented.Antipsychotics:
In depressed patients with schizophrenic or schizoaffective disorder, psychotic symptoms may be exacerbated during treatment with moclobemide. There is little experience regarding the concomitant use of moclobemide and antipsychotic drugs. Therefore, patients should be carefully monitored should concomitant treatment be undertaken.Alcohol:
Excessive alcohol consumption should be avoided. Alcohol interaction studies were performed at blood alcohol concentrations of 0.5%. However, no studies were conducted at blood alcohol concentrations recognized as legally intoxicating.Anesthetic Agents:
It is accepted medical practice to discontinue treatment with conventional MAO inhibitors 10 to 14 days before the administration of anesthetic agents, especially spinal or local anesthetic agents that contain epinephrine. While specific data on the use of moclobemide in patients undergoing anesthesia are not available, based on the reversible action and short elimination half-life of 'Manerix' (see Pharmacology) this period may be shortened to no less than 2 days.Sympathomimetics:
Following multiple oral doses of moclobemide (200 mg t.i.d.), a phenylephrine-induced increase in systolic blood pressure was potentiated after i.v. administration. Patients should be advised to avoid the concomitant use of all sympathomimetic amines (e.g., amphetamine and ephedrine like compounds contained in many proprietary cold, hay fever or weight-reducing preparations), until further studies have been conducted.Antihypertensive Agents:
Clinical trials with moclobemide have shown inconsistent effects on the blood pressure of hypertensive patients. Therefore, careful monitoring is recommended during initial treatment.
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Adverse Effects
Table I lists the adverse events reported during clinical trials in which 1922 patients were treated with 50 to 600 mg/day moclobemide for depressive illness. Limited experience in 60 patients treated with 601 to 750 mg/day of moclobemide suggests that the incidence of adverse reactions may increase at higher doses.(adverse reaction table can be found at: http://www.mentalhealth.com/fr30.html )
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Dosage
Note:
Moclobemide should always be taken after meals in order to minimize tyramine potentiation and the possibility of a hypertensive reaction (see Pharmacology and Drug Interactions).
Usual Adult Dosage:
The administration of moclobemide should be initiated at 300 mg daily dose (usually administered in 3 divided doses), and increased gradually if needed, noting carefully the clinical response and any evidence of intolerance. As with other antidepressants, it should be kept in mind that there may be a lag time in therapeutic response. There is no evidence that increasing the dosage rapidly shortens this latent period and may, in fact, increase the incidence of side effects.Individual response may allow a reduction of the daily dose to 150 mg or an increase to a maximum of 600 mg/day, depending on the severity of the depression. In clinical trials, the majority of patients responded to doses of 450 mg or less.
Liver Dysfunction:
In patients with severe liver dysfunction, the daily dose of moclobemide should be reduced to one-third or one-half of the standard dose.Renal Dysfunction:
Single dose pharmacokinetic data suggest that no dosage adjustment may be required in patients with impaired renal function. However, multiple dose studies with moclobemide have not been performed in patients with renal dysfunction, therefore, moclobemide should be used with caution in this patient population. In normal volunteers, the absolute bioavailability almost doubles following multiple dosing as compared to a single dose.Geriatrics:
No dosage adjustments are necessary in elderly patients.Cimetidine:
Cimetidine doubles the AUC (area under the plasma concentration-time curve) of moclobemide and is expected to approximately double moclobemide steady-state concentrations (see Pharmacology).In patients treated with cimetidine, it is recommended that moclobemide be initiated at the lowest recommended dose, i.e., 100 to 200 mg/day.
In patients treated with moclobemide, a 50% reduction in the dosage of moclobemide may be necessary before commencing cimetidine treatment.
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Supplied
100 mg:
Each orange, single-scored, biconvex, film-coated tablet imprinted "ROCHE 100" on one side, and single scored on the other, contains: Moclobemide 100 mg. Nonmedicinal ingredients: Cornstarch, ethylcellulose, lactose, magnesium stearate, methylhydroxypropyl cellulose, povidone, red iron oxide, sodium starch glycolate, talc, titanium dioxide and yellow iron oxide. Gluten-free, parabens-free, sucrose-free, sulfites-free and tartrazine-free. Bottles of 100.
150 mg:
Each pale yellow, single-scored, biconvex, film-coated tablet imprinted "ROCHE 150" on one side, single scored on the other, contains: Moclobemide 150 mg. Nonmedicinal ingredients: Same as 100 mg tablet plus polyethylene glycol. Gluten-free, parabens-free, sucrose-free, sulfites-free and tartrazine-free. Bottles of 100.Store at 15 to 30°C.
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Research
The research information is available separately on Internet Mental Health.
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Note: This information is from a Canadian monograph. There can be differences in indications, dosage forms and warnings for this drug in other countries.
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Internet Mental Health (www.mentalhealth.com) copyright © 1995-1999 by Phillip W. Long, M.D.
Posted by Ginjoint on October 2, 2002, at 16:03:01
In reply to I have a dr.'s dissapointment today., posted by Gabbix2 on October 2, 2002, at 15:06:41
Hey Gabbi...
"Manerix"...sounds like Good Manners In A Pill. ;) Or: How To Get Bipolars, Depressives, et al., To Behave Properly In Polite Society. I just thought the name was kinda funny...I hope you're smiling with me...
Ginjoint
P.S. Thanks for the love, and right back atcha.
Posted by tina on October 2, 2002, at 16:27:12
In reply to Thank you Twice -Gin Joint -Sandra Dee., posted by Gabbix2 on October 2, 2002, at 12:02:03
Posted by tina on October 2, 2002, at 17:24:33
In reply to I have a dr.'s dissapointment today., posted by Gabbix2 on October 2, 2002, at 15:06:41
Hey Gabbi
Just wanted you to know that Manerix was the first AD my doc put me on 13 years ago and it cured me. I was illness-free for 5 years thanks to a combo of Manerix and clonazepam. Not a single side effect either. I was even able to stop taking it and remained in pretty good shape for a couple of years after that. When this latest bout of depression started a couple of years ago, I tried the Manerix again but it just didn't work this time. Damn it. It would have been great had it worked.
Give it a try. It was fantastic for me. It might work for you too. I was taking 450mg/day.
Good luck and let me know how it goes.
Tina
Posted by Ted on October 2, 2002, at 18:11:43
In reply to Re: I have a dr.'s dissapointment today. » Gabbix2, posted by Ginjoint on October 2, 2002, at 16:03:01
Posted by Gabbix2 on October 2, 2002, at 18:24:30
In reply to Manerix...........long information perhaps for PB » Gabbix2, posted by alii on October 2, 2002, at 15:43:35
Posted by Gabbix2 on October 2, 2002, at 18:28:35
In reply to Re: I have a dr.'s dissapointment today. » Gabbix2, posted by Ginjoint on October 2, 2002, at 16:03:01
Yup I'm smilin with ya.
That was funny! sounded frightengly like something I'd say you know there is actually a drug called SOMA.Freaky.
Too late for me though, they should have put more alcohol in my decanter while they had the chance.
Posted by Roo on October 3, 2002, at 9:21:09
In reply to Hey Gin Joint! thanks Tina! I will let you know., posted by Gabbix2 on October 2, 2002, at 18:28:35
Gabbi--
Hope the Mannerix works! You made me laugh at
the sea cucumber thing! It's pretty impressive you
can feel so shitty and still be so damn funny!
"I have to say, I looked pretty damn cute!"You deserve a break from hell...
This is the end of the thread.
Psycho-Babble Social | Extras | FAQ
Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.org
Script revised: February 4, 2008
URL: http://www.dr-bob.org/cgi-bin/pb/mget.pl
Copyright 2006-17 Robert Hsiung.
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