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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 11 of 11. This is the beginning of the thread.
Posted by Helena24 on March 23, 2010, at 16:55:07
Hi,(sorry for my bad English).
I'm currently on 10 mg Strattera and experiencing strong dysphoria (wich I'm managing with diazepam and Tianeptine).A few years ago I startet taking 40 mg Stattera but I had to quit shortly due to extreme somnolence and irritability.
I have ADD and depression.
Now I learnt that a second metabolite of atomoxetine is a partial agonist on the kappa opioid receptor (the stimulation of it is thought to decrease dopamine function in the striatum).
Could the dysphoria be because of this action?
I have been on desipramine bevore and it didn't cause dyspohoria (it's not available were I live).
I never tried reboxetine.
Is there someone who took both ,Strattera and Reboxetine ,a tell if this two drugs work differently?Is a ''low dopamine deep limbic ADD'' (sorry if this is not a scientifical term) be worsened by a kappa agonism due to antidopaminergic action?
Could this be linked to the suicidility that Strattera sometimes causes?
I feel a stronger need to take more Tianeptine since I am on Strattera.Maybe because I need my dopamine function restored?
Thoughts?
Posted by europerep on March 28, 2010, at 14:26:08
In reply to Atomoxetine and kappa-opioid-receptor agonism, posted by Helena24 on March 23, 2010, at 16:55:07
hey there..
first of all, where is the bad english you were refering to? ;)
indeed, kappa-agonism does seem to have negative effects on mood disorders, but I cannot say anything about its effects in ADD, etc..
but, since this is a somewhat medication-related topic, it might be moved to "medication", where I am sure that you'd get responses.. the neurotransmitter-forum is less frequented I guess..do you mind me asking where you are from? southern or eastern europe? if so, hello not-so-far-neighbor ;)
Posted by Dr. Bob on March 30, 2010, at 3:28:31
In reply to REDIRECT? - Atomoxetine and kappa-receptor agonism, posted by europerep on March 28, 2010, at 14:26:08
> since this is a somewhat medication-related topic, it might be moved to "medication", where I am sure that you'd get responses..
If one of you wants to post a link there, that's fine, but I think this is the most appropriate board for this thread, since it has to do with kappa-agonism, etc. Thanks,
Bob
Posted by Helena24 on March 31, 2010, at 9:56:34
In reply to Atomoxetine and kappa-opioid-receptor agonism, posted by Helena24 on March 23, 2010, at 16:55:07
Oh I just saw your responses.
Well,I just postet a similar question to the medication board because I didnt't get any answers here.
Well the questions I ask here are a bit ''advanced'' I'm afraid.
My other question is ''simpler'' set.I'm still hoping for aswers... :(
Posted by Helena24 on March 31, 2010, at 9:59:35
In reply to REDIRECT? - Atomoxetine and kappa-receptor agonism, posted by europerep on March 28, 2010, at 14:26:08
Oh,I forgot to tell,I live in Greece.
Posted by desolationrower on March 31, 2010, at 21:23:14
In reply to Atomoxetine and kappa-opioid-receptor agonism, posted by Helena24 on March 23, 2010, at 16:55:07
given the affinities, i would think this is more relevent at higher doses of atomoxetine
-d/r
Posted by Helena24 on April 1, 2010, at 6:30:09
In reply to Re: Atomoxetine and kappa-opioid-receptor agonism, posted by desolationrower on March 31, 2010, at 21:23:14
Could it be that some individuals have ''more'' kappa opioid receptors than ''normal'' and therefore are more sensitive to drugs that stimulate them?
Just a thought.
The dysphoria was unbearable.I had to quit the drug.
Posted by desolationrower on April 23, 2010, at 17:09:38
In reply to Re: Atomoxetine and kappa-opioid-receptor agonism, posted by Helena24 on April 1, 2010, at 6:30:09
sure, though its just a guess. i chose nortriptaline not attomoxetine mostly for this reason (also $)
-d/r
Posted by Helena24 on April 23, 2010, at 17:16:22
In reply to Re: Atomoxetine and kappa-opioid-receptor agonism, posted by desolationrower on April 23, 2010, at 17:09:38
In my oppinion low dose Nortriptylin and Desipramin are much better drugs for ADD than Atomoxetine,but ''under-promotet'' because they are cheap.
Atomoxetine is not worth the hype,really not!
Posted by Conundrum on May 27, 2010, at 20:57:22
In reply to Re: Atomoxetine and kappa-opioid-receptor agonism, posted by desolationrower on April 23, 2010, at 17:09:38
Sorry to butt in here, but d/r you take nortriptyline for ADHD? How does that help you? Does it just help with concentration or forming new memories?
Posted by Helena24 on May 28, 2010, at 14:21:55
In reply to Re: Atomoxetine and kappa-opioid-receptor agonism » desolationrower, posted by Conundrum on May 27, 2010, at 20:57:22
Both,but only in low dosage and the effectivness gets less with time.
I'm not taking it currently.
This is the end of the thread.
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