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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 4 of 4. This is the beginning of the thread.
Posted by Lascap on April 5, 2010, at 11:13:35
Hi everyone,
I hope you can put this in perspective for me. I have an extreme sensitivity to Pseudoephedrine (think Advil Cold & Sinus). Now, I understand this is not supposed to happen, but even small doses (e.g. 1/4 of a pill, ~7.5 mg) make me feel extremely good (to the point of euphoria), give me lots of energy and productivity and also lots of ideas (creativity). This effect is unlikely to be a placebo effect - it took me completely by surprise a couple of years ago when taking Advil Cold & Sinus for a cold. I have since isolated the effective component as Pseudoephedrine. Sadly, there is a dark side. After stopping to take it, there is a huge hangover. Depression-like sadness, no energy, no ideas. This can last for days.
Now, I understand none of this is supposed to happen. Does anyone have any insight as to what neurotransmitter system could be involved? Or what idiosyncracies my physiology (sensitivities) might have to produce this effect?
Personally, I am at a loss. Any hint is greatly appreciated.
Thanks.
Posted by Deneb on April 6, 2010, at 19:46:58
In reply to Extreme sensitivity to Pseudoephedrine, posted by Lascap on April 5, 2010, at 11:13:35
Hello Lascap
Welcome to Psycho-Babble! I have no idea what neurotransmitters are involved, but excitability is often a side effect of cold medicine for children. I think euphoria would fit into that as well.
I had that side effect as a child and I loved feeling that way. I don't remember any crash though.
Posted by Katgirl on April 7, 2010, at 17:37:35
In reply to Re: Extreme sensitivity to Pseudoephedrine » Lascap, posted by Deneb on April 6, 2010, at 19:46:58
Hi-
I can't even take pseudophedrine (for my sinus congestion) because even the lowest dose puts my anxiety through the roof. But I am overly sensitive to almost anything. Do you have sensitivity to other drugs as well??
And sorry, I don't know what part of the brain it hits, but I'm thinking something to do with norephinephrine or dopamine since it makes me so speedy and agitated.
Posted by desolationrower on April 23, 2010, at 17:20:35
In reply to Extreme sensitivity to Pseudoephedrine, posted by Lascap on April 5, 2010, at 11:13:35
i'd try nortryptaline/desipramine, and then bupropion. mas is stronger.
-d/r
This is the end of the thread.
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