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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 5 of 5. This is the beginning of the thread.
Posted by linkadge on January 26, 2016, at 15:25:24
Has anyone had improved reaction to the "activated" form of B12 (methlycobolamine) vs. cyanocobolamine ?
Linkadge
Posted by Larry Hoover on January 27, 2016, at 18:14:47
In reply to methylcobolamine vs. cyanocobolamine, posted by linkadge on January 26, 2016, at 15:25:24
> Has anyone had improved reaction to the "activated" form of B12 (methlycobolamine) vs. cyanocobolamine ?
>
> LinkadgeHey, Link. I hope you are well.
Cyanocobalamin is an artefact of early biochemistry. The first isolation of this molecule was with cyanide extraction. It is not the natural form of the molecule. In fact, I have read that the biochemical benefit of one molecule of cobalamin is exactly counteracted by the biochemical burden of neutralizing one molecule of cyanide. Net benefit zero. Other sources don't support the extent of the negative impact of the cyanide moiety, as it can also be neutralized by glutathione. But, ultimately, given that cyanocobalamin is not found in nature, why not take the natural form, methylcobalamin? It's not activated in any way; it's simply not combined with the negative impact of a cyanide molecule. Hydroxycobalamin is an equivalent natural form of B12.
Sublingual methylcobalamin is a very effective way to take this vitamin. If swallowed, it requires binding to an uptake transporter in the small intestine for absorption. Passing directly into the blood through the oral mucosa is more efficient.
Best,
Lar
Posted by linkadge on January 27, 2016, at 19:16:41
In reply to Re: methylcobolamine vs. cyanocobolamine » linkadge, posted by Larry Hoover on January 27, 2016, at 18:14:47
Thanks for the info. I noticed a quite significant increase in energy after 1000mcg of methylcobalamine, but it became a bit too intense as the day progressed. I reduced to 250 mcg today with a better effect.
Linkadge
Posted by Larry Hoover on January 29, 2016, at 21:33:48
In reply to Re: methylcobolamine vs. cyanocobolamine, posted by linkadge on January 27, 2016, at 19:16:41
You're welcome.
There is a significant carryover from supplementation, because B12 is stored in the body very efficiently. Your experience from acute exposure of a substantial dose will also have some lasting effects.
There is no known overdose level of B12, but as always, titration by personal experience is advised.
Lar
Posted by herpills on February 16, 2016, at 15:31:16
In reply to methylcobolamine vs. cyanocobolamine, posted by linkadge on January 26, 2016, at 15:25:24
This is the end of the thread.
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