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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 7 of 7. This is the beginning of the thread.
Posted by linkadge on May 21, 2007, at 18:06:16
Hi, I am interested in supplements that may increase the synthesis of melatonin. I understand that b12 can help, also 5-ht2a blockers at nighttime appear to increase melatonin synthsis.
Does anyone know of others? In particular, does vitamin D have any effect on melatonin synthsis ?
ThanksLinkadge
Posted by djmmm on May 22, 2007, at 8:53:58
In reply to Increasing melatonin synthesis ?, posted by linkadge on May 21, 2007, at 18:06:16
> Hi, I am interested in supplements that may increase the synthesis of melatonin. I understand that b12 can help, also 5-ht2a blockers at nighttime appear to increase melatonin synthsis.
>
> Does anyone know of others? In particular, does vitamin D have any effect on melatonin synthsis ?
>
>
> Thanks
>
> LinkadgePerhaps supplements like 5-HTP would increase melatonin synthesis..since melatonin is manufactured from serotonin (5-HTP---> serotonin--->N-acetylserotonin--->melatonin) Why not just take the supplement melatonin?
Posted by Sigismund on May 22, 2007, at 16:30:17
In reply to Re: Increasing melatonin synthesis ?, posted by djmmm on May 22, 2007, at 8:53:58
Cannabis certainly increases melatonin levels, at least for a while.
Posted by sregan on May 23, 2007, at 15:22:50
In reply to Increasing melatonin synthesis ?, posted by linkadge on May 21, 2007, at 18:06:16
> Hi, I am interested in supplements that may increase the synthesis of melatonin. I understand that b12 can help, also 5-ht2a blockers at nighttime appear to increase melatonin synthsis.
>
> Does anyone know of others? In particular, does vitamin D have any effect on melatonin synthsis ?
>
>
> Thanks
>
> LinkadgeFROM: http://phoenix-cfs.org/GSH%20Methylation%20Van%20Konynenburg.htm
"Durlach et al. have found that magnesium depletion is associated with abnormalities in the level of melatonin and dysregulation of biorhythms (129)."
"The production of melatonin from serotonin as well as the metabolism of the catecholamines require methylation, as noted earlier, and according to the GD-MCB Hypothesis, they are inhibited because of the decreased methylation capacity."
Posted by LOOPS on May 24, 2007, at 7:26:12
In reply to Re: Increasing melatonin synthesis ?, posted by sregan on May 23, 2007, at 15:22:50
Well I've noticed that since eating quite a bit of animal protein, taking liver tablets and magnesium I fall asleep way earlier in the evening - sometimes as early as 10pm (I don't have to get up very early either).
But it's getting on to be Winter here in Chile anyway.
Loops
Posted by djmmm on May 25, 2007, at 7:03:35
In reply to Increasing melatonin synthesis ?, posted by linkadge on May 21, 2007, at 18:06:16
> Hi, I am interested in supplements that may increase the synthesis of melatonin. I understand that b12 can help, also 5-ht2a blockers at nighttime appear to increase melatonin synthsis.
>
> Does anyone know of others? In particular, does vitamin D have any effect on melatonin synthsis ?
>
>
> Thanks
>
> LinkadgeRead this:
MELATONIN SYNTHESIS AND METABOLISM
http://www.endotext.org/neuroendo/neuroendo15/ch01s02.html
Posted by qqqsimmons on May 26, 2007, at 17:01:02
In reply to Increasing melatonin synthesis ?, posted by linkadge on May 21, 2007, at 18:06:16
can you explain what melatonin synthesis is and why you want more of it?
are you trying to simulate the effects of the melatonin agonist rozerem? i've heard rozerem is the only prescription sleep aid that's non-habit forming...
i believe that taking melatonin may have similar effects. i've been microdosing with it lately. between 10-100 micrograms...i saw that Life Extensions has a delayed release product of 333 mcg tablets...not sure if they can be broken to smaller bits...
i think magnesium or b2 can be helpful if taken with melatonin, as they should help eat up stimulant neurotransmitters. without melatonin, i believe mg and b2 can interfere with one's natural melatonin production and cause insomnia.
This is the end of the thread.
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