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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 16 of 16. This is the beginning of the thread.
Posted by falconman on January 18, 2007, at 21:29:19
Hi its been a while since I've posted.
Has anyone tried Phenylethylamine for depression/anxiety? Maybe you've used it with low dose selegiline(deprenyl)? Can you buy it, or would you have to get DL-phenylalanine? I'm interested in any comments regarding this drug and its effects.
Thanks falconman
Posted by Jimmyboy on January 18, 2007, at 21:29:20
In reply to Phenylethylamine, posted by falconman on January 17, 2007, at 9:22:11
Yes , I have tried it, you have to use it with low dose Selegiline ( 5-10 mg) in order to inhibit MAO B which in turn rapidly destroys the PEA before it can have any effect.
You can buy PEA Hcl powder, but I ( and no one else I have seen) would recommend it. Its too strong, hard to measure, too stimulating and way too short acting.
But, I did have better success on Selegliine DLPA, it was a lot better for me personally and I know a few other people here had success with it. So you might want to go that route. Also exercise along with it puts out more PEA also.
Good luck
JB
Posted by ryanz on January 18, 2007, at 21:29:20
In reply to Re: Phenylethylamine, posted by Jimmyboy on January 17, 2007, at 10:18:06
There's another thread going on about this subject elsewhere on the page. You might want to read the comments and follow the links at the following page:
You'll need an electronic scale accurate to at least .01 grams to measure the powder if you buy it. The studies used 60mg of PEA. The cost of these very widely from under $30 to over a $100. PEA itself is cheap; it will actually cost more for the shipping than the actual product per month. A source is listed at the above link.
Ideally, a trial with this would be most appropriate for people already taking the new antidepressant patch Emsam (selegiline) for depression as a potential way to augment the treatment.
I haven't tried it, but I would think it would be more appropriate for those with the shut-down, dead-inside, tired, fatigued, zombie-like depression rather than the emotional, anxiety-prone type.
What limited studies there are suggest that it is effective in up to 60% of people who try it.
I would not use a precursor, but rather phenylethylamine itself, as that is what was used in the studies and I'm not convinced that precursor is effective.
Posted by bulldog2 on January 18, 2007, at 21:29:20
In reply to Re: Phenylethylamine, posted by Jimmyboy on January 17, 2007, at 10:18:06
I would agree that you need selegiline for either supplement because they are short acting. Tried selegiline and pea and didn't like the feeling. I did like the selegiline with dlpa. With dlpa I believe you get conversion to dopamine,norepinephrine as well as pea.
Posted by djmmm on January 18, 2007, at 21:29:21
In reply to Phenylethylamine, posted by falconman on January 17, 2007, at 9:22:11
> Hi its been a while since I've posted.
> Has anyone tried Phenylethylamine for depression/anxiety? Maybe you've used it with low dose selegiline(deprenyl)? Can you buy it, or would you have to get DL-phenylalanine? I'm interested in any comments regarding this drug and its effects.
> Thanks falconmanI use low dose selegiline (liquid deprenyl citrate) (2mg) along with 500mg of PEA (2 x 250mg)
along with a couple other herbs and supplements/nootropics(phenylethylamine) PEA is a strange supplement, you HAVE to keep the dose very low. At high doses, it is almost indistinguishable from MDMA. I certainly dont recommend it if you have any problems with stimulant abuse, or high blood pressure.
I would compare PEA/selegiline combo to the older version of Nardil (minus the insomnia and weight gain) I'm not depressed, I feel highly motivated, and pro-social.
PEA is VERY inexpensive-- about $1.00 per gram, I order mine from custom nutrition warehouse.
Since PEA is a legal supplement, I believe I can give you the link:http://customnutritionwarehouse.com/pea-p-1127.html?osCsid=d694b2be4464f72347e2c3596f6fb1b5
Posted by falconman on January 18, 2007, at 21:29:21
In reply to Re: Phenylethylamine, posted by djmmm on January 17, 2007, at 16:02:09
> > Hi its been a while since I've posted.
> > Has anyone tried Phenylethylamine for depression/anxiety? Maybe you've used it with low dose selegiline(deprenyl)? Can you buy it, or would you have to get DL-phenylalanine? I'm interested in any comments regarding this drug and its effects.
> > Thanks falconman
>
> I use low dose selegiline (liquid deprenyl citrate) (2mg) along with 500mg of PEA (2 x 250mg)
> along with a couple other herbs and supplements/nootropics
>
> (phenylethylamine) PEA is a strange supplement, you HAVE to keep the dose very low. At high doses, it is almost indistinguishable from MDMA. I certainly dont recommend it if you have any problems with stimulant abuse, or high blood pressure.
>
> I would compare PEA/selegiline combo to the older version of Nardil (minus the insomnia and weight gain) I'm not depressed, I feel highly motivated, and pro-social.
>
> PEA is VERY inexpensive-- about $1.00 per gram, I order mine from custom nutrition warehouse.
>
> Since PEA is a legal supplement, I believe I can give you the link:
>
> http://customnutritionwarehouse.com/pea-p-1127.html?osCsid=d694b2be4464f72347e2c3596f6fb1b5
>
Hi,
thanks for the link. If you don't mind me asking, what other supplements/nootropics do you take and what are the effects.
Thanks
>
Posted by dbc on January 18, 2007, at 21:29:21
In reply to Re: Phenylethylamine, posted by falconman on January 17, 2007, at 16:18:00
Im not sure why you would want PEA but DLPA is available everywhere.
Personally im not suicidal so i wouldnt mix anything with an MAOI.
Posted by djmmm on January 18, 2007, at 21:29:21
In reply to Re: Phenylethylamine, posted by dbc on January 17, 2007, at 17:05:29
> Im not sure why you would want PEA but DLPA is available everywhere.
>
> Personally im not suicidal so i wouldnt mix anything with an MAOI.lol... Personally, I'm not suicidal...thanks to various medications combined with MAOIs (over many many years) :)
Nardil multi amino acid powder
Nardil tegretol
Nardil zonegran
Nardil neurontin topamax
Nardil neurontin topamax inderal
Nardil xanax
Nardil Klonopin
Nardil ritalin
Parnate Klonopin
Parnate klonopin inderal
Parnate Neurontin
Parnate amino acid powder
No reactions to MAOI with stimulants, l-methamphetamine(vicks inhaler), Oxymetazoline hydrochloride, ephedra, pseudoephedra, or dextromethorphan.I did have a mild reaction to Parnate and cheese Tortellini.. of all things.
From my experience, and research, hypertensive crisis is rare. Mild hypertensive episodes are more common (still rare) and typically require no medical intervention. Pubmed has many journal abstracts from the 1960's to current--supporting this.
Posted by djmmm on January 18, 2007, at 21:29:21
In reply to Re: Phenylethylamine, posted by falconman on January 17, 2007, at 16:18:00
I also take Klonopin (.5mg) acetyl-l-carnitine, bacopa, rhodiola, and a b-complex vitamin
Posted by dbc on January 18, 2007, at 21:29:21
In reply to Re: Phenylethylamine, posted by djmmm on January 17, 2007, at 18:22:41
Im a big silly hypochondriac so the thought of MAOIs scare me.
....now wheres my ativan...
Posted by falconman on January 18, 2007, at 21:29:21
In reply to Re: Phenylethylamine, posted by djmmm on January 17, 2007, at 18:22:41
> I also take Klonopin (.5mg) acetyl-l-carnitine, bacopa, rhodiola, and a b-complex vitamin
Hi,
i've tried rhodiola before without benefit. Its interesting in your previous post you mention combining Nardil with Ephedra. I have used Ephedrine Hcl in combination with Klonopin and it does help alot. The only problem is that I get accostomed to a dose within about 1 week. I have to take breaks from using it and I usually feel worse than before I took it. It is however another piece of evidence that I might benefit from taking a stim like PEA or provigil. I'm just worried that the same will happen with them. Do you develop tolerance to PEA?
Thanks
Posted by LongRoad on April 6, 2011, at 18:51:35
In reply to Re: Phenylethylamine, posted by Jimmyboy on January 18, 2007, at 21:29:20
What about mixing Phenylethylamine with a naturally occurring MAOI like piperine? Would that help slow the breakdown or is it not strong enough of an maoi?
Posted by Questionmark on May 12, 2011, at 15:56:23
In reply to Re: Phenylethylamine, posted by djmmm on January 18, 2007, at 21:29:21
Wait, really? I def think the dietary restrictions for MAOIs are highly exaggerated, but ephedrine, amphetamines, and dextromethorphan would seem VERY risky.
On Nardil, I have used methylphenidate several times, and oxymetazoline many times, without adverse reaction.
However... i went to ER w bad hypertensive reaction after mindlessly taking 50mg ephedrine early in my Nardil taking; found even very-low dose Adderal to be highly dysphoric and imagine it would be dangerous in higher doses; and sometimes when i run out of Nardil, i will take a *tiny* sip of dextromethorphan containing cough medicine for its SRI properties, and i can easily see someone getting serotonin syndrome from it while on Nardil.
You make a great overall point, but i would be careful of underplaying the risk of certain mixtures a little *too* much.
> > Im not sure why you would want PEA but DLPA is available everywhere.
> >
> > Personally im not suicidal so i wouldnt mix anything with an MAOI.
>
> lol... Personally, I'm not suicidal...thanks to various medications combined with MAOIs (over many many years) :)
>
> Nardil multi amino acid powder
> Nardil tegretol
> Nardil zonegran
> Nardil neurontin topamax
> Nardil neurontin topamax inderal
> Nardil xanax
> Nardil Klonopin
> Nardil ritalin
> Parnate Klonopin
> Parnate klonopin inderal
> Parnate Neurontin
> Parnate amino acid powder
>
>
> No reactions to MAOI with stimulants, l-methamphetamine(vicks inhaler), Oxymetazoline hydrochloride, ephedra, pseudoephedra, or dextromethorphan.
>
> I did have a mild reaction to Parnate and cheese Tortellini.. of all things.
>
> From my experience, and research, hypertensive crisis is rare. Mild hypertensive episodes are more common (still rare) and typically require no medical intervention. Pubmed has many journal abstracts from the 1960's to current--supporting this.
Posted by Questionmark on May 15, 2011, at 23:05:32
In reply to Re: Phenylethylamine, posted by Questionmark on May 12, 2011, at 15:56:23
Didn't realize i was responding to a 4 year old post. My bad.
Posted by LongRoad on May 15, 2011, at 23:38:03
In reply to (Woops)... Re: Phenylethylamine, posted by Questionmark on May 15, 2011, at 23:05:32
I posted recently - that's why this thread came alive again - trying to determine if PEA could be useful with a natural MAOI and if so, which do you think could work?
Posted by Questionmark on May 23, 2011, at 19:20:48
In reply to Re: (Woops)... Re: Phenylethylamine, posted by LongRoad on May 15, 2011, at 23:38:03
I really don't think piperine would work. i've taken this a number of times and never noticed any psychoactivity.
I have on a number of occasions noticed a significant increase in mood and sociability (for about a few hours maybe) after eating dark chocolate while on Nardil.
PEA was my guess as to the reason.However, if you are specifically looking to potentiate PEA, a more MAO-B selective MAOI like selegeline or Parnate would prob be preferable to Nardil.
It's possible that a natural MAO-B inhibitor like Fo-Ti would work somewhat as well, but as with piperine, i have tried this and noticed nothing. But that's me.> I posted recently - that's why this thread came alive again - trying to determine if PEA could be useful with a natural MAOI and if so, which do you think could work?
This is the end of the thread.
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