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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 7 of 7. This is the beginning of the thread.
Posted by kiwiredbeach on October 21, 2006, at 17:13:52
After my wonderful joyful experience with glutamine powder does everyone know any natural antagonist to glutamate.
Regards Kiwiredbeach
Is Mg a nmda receptor antagonist
Posted by nolvas on October 21, 2006, at 18:53:32
In reply to Natutal glutamate antagonist, posted by kiwiredbeach on October 21, 2006, at 17:13:52
Ah you had to ask! heheh.
Aspartic Acid competes with Glutamate for absorption.
GABA may inhibit the release of Glutamic Acid within the Brain (by binding to and activating GABAb Receptors).
These Substances may Counteract the Toxic Effects of Glutamic Acid
Alkaloids
Huperzine A (a component of Club Moss) may inhibit the excitotoxin effects of Glutamic Acid on the Hippocampus.
Amino Acids
Acetyl-L-Carnitine (ALC) may help to protect Neurons from the excitotoxic effects of excessive Glutamic Acid.
N-Acetyl-Cysteine (NAC) may inhibit the excitotoxic effects of Glutamic Acid.
Pyroglutamate may protect Neurons against the toxic effects of excessive Glutamic Acid.Theanine may inhibit the ability of excessive Glutamic Acid to damage Neurons.
Hormones
Dehydroepiandrosterone (DHEA) may exert protective effects in the Brain that may counteract the ability of Glutamic Acid to function as an excitotoxin.
Estradiol 17-Beta (which is produced by Astrocytes in the Brain by the Aromatase group of enzymes) may protect Neurons from the excitotoxic effects of Glutamic Acid.
Glucagon catalyzes the conversion of Glutamic Acid to endogenous Glucose.Lipids
Docosahexaenoic Acid (DHA) may protect the Neurons of the Hippocampus from the toxic effects of excessive Glutamic Acid.
Ginsenoside Rb1 may protect the Neurons of the Hippocampus from the toxic effects of excessive Glutamic Acid.
Ginsenoside Rg1 may protect the Neurons of the Hippocampus from the toxic effects of excessive Glutamic Acid.Ginsenoside Rg3 may protect Neurons from the toxic effects of excessive Glutamic Acid.
Minerals
Lithium may help to prevent Glutamic Acid from over-stimulating NMDA Receptors (N-methyl-D-aspartate Receptors) in the Brain (and may thereby help to prevent the death of Neurons caused by Glutamic Acid over-stimulation).
Magnesium may counteract the toxicity of Glutamic Acid.Selenium may counteract the toxicity of Glutamic Acid.
Peptides
Carnitine may counteract the toxic effects of excessive Glutamic Acid.
Pharmaceutical DrugsNMDA Receptor Blockers inhibit the ability of Glutamic Acid to over-excite N-Methyl-D-Aspartate (NMDA) Receptors:
- Memantine inhibits the ability of Glutamic Acid to over-excite N-Methyl-D-Aspartate (NMDA) Receptors.
Polyphenols
Pycnogenol may protect the body against the toxic effects of excessive Glutamic Acid.
Quinones
Coenzyme Q10 may counteract the toxicity of Glutamic Acid.
Smart Drugs
Deprenyl may help to protect Neurons from the excitotoxic effects of excessive Glutamic Acid. references
Idebenone may protect the Brain against the toxicity of Glutamic Acid.
Vinpocetine may help to prevent damage to Neurons caused by exposure to excessive levels of Glutamic Acid (due to the Antioxidant properties of Vinpocetine).Vitamins
Alpha-Tocotrienol may inhibit the ability of Glutamic Acid to exert excitoxic effects on Neurons.
Cytidine Diphosphate Choline (CDP-Choline) may help to protect Neurons from the excitotoxic effects of excessive Glutamic Acid.
Folic Acid may counteract the toxicity of Glutamic Acid.Lipoic Acid may inhibit the excitotoxic effects of Glutamic Acid.
Vitamin B2 may protect against the neurotoxic effectsof Glutamic Acid.
Vitamin B12 (especially the Methylcobalamin form of Vitamin B12) may help to prevent the damage to Neurons caused by exposure to excessive levels of Glutamic Acid.
Vitamin C may protect against the neurotoxic effects of excessive Glutamic Acid.
Vitamin E may counteract the toxicity of Glutamic Acid.These Herbs may Counteract the Toxic Effects of
Club Moss may inhibit the excitotoxin effects of Glutamic Acid on the Hippocampus (due to the Huperzine A content of Club Moss).
Ginkgo biloba may counteract the toxic effects of Glutamic Acid on Neurons (primarily due to the Ginkgolide-B content of Ginkgo biloba).
Gotu Kola may inhibit the excitotoxin effects of Glutamic Acid (due to the Asiatic Acid content of Gotu Kola).Korean Ginseng may prevent the swelling (Inflammation) of Astrocytes caused by the excitotoxin effects of excessive Glutamic Acid.
Schizandra may inhibit the excitotoxic effects of Glutamic Acid (i.e. Schizandra may inhibit the ability of Glutamic Acid to damage Neurons).
Posted by linkadge on October 21, 2006, at 19:48:20
In reply to Re: Natutal glutamate antagonist, posted by nolvas on October 21, 2006, at 18:53:32
The ability of certain agents to provide protection against excessive glutamatergic neurotransmission is mediated in part by a BDNF dependant mechanism.
The protection afforded by lithium, for instance, is abilolished by a BDNF neutralizing antibody.
As such, drugs that enhance BDNF could provide a similar protection.
Linkadge
Posted by kiwiredbeach on October 22, 2006, at 4:21:09
In reply to Natutal glutamate antagonist, posted by kiwiredbeach on October 21, 2006, at 17:13:52
Wow thanks for the answers
Nice to know that even with Larry Hoover gone there are people with great knowledge.
Cheers KiwiRedbeach
Ps what ever happened to larry, did he get better and if so does any one know what was the magical cure...I hear he was trying lyrica
Posted by Meri-Tuuli on October 22, 2006, at 6:13:59
In reply to Re: Natutal glutamate antagonist, posted by kiwiredbeach on October 22, 2006, at 4:21:09
hey..
> Ps what ever happened to larry, did he get better and if so does any one know what was the magical cure...I hear he was trying lyrica
Hmm..... Philipa knows, I get the impression he was just having a break from babble - perhaps this is a permanent thing. I don't think he is coming back, unfortunately. He is a legend for sure.
Kind regards
Meri
Posted by Tom Twilight on October 25, 2006, at 8:18:52
In reply to Re: Natutal glutamate antagonist, posted by Meri-Tuuli on October 22, 2006, at 6:13:59
High all
I know I haven't been posting much lately, but this thread has really got my attention!
I'm going to post a thread on the main board, concentrating on Chemical Glutimate agonists.
I should mention that Taurine is also a Glutimate Agonist, Apparently
Posted by sregan on October 26, 2006, at 21:33:15
In reply to Re: Natutal glutamate antagonist, posted by kiwiredbeach on October 22, 2006, at 4:21:09
> Nice to know that even with Larry Hoover gone there are people with great knowledge.
I doubt I can hold a candle to Larry but glutamate agantagonists are:
Magnesium (perhaps the most famous)
Zinc
TaurineGABA agonists are supposed to work similar.
Valerian
GABA
Theanine (this really works for me)Shawn
This is the end of the thread.
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