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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 7 of 7. This is the beginning of the thread.
Posted by btnd on October 11, 2003, at 5:48:57
Hi,
Do you know of any evidence on L-Theanine increasing GABA brain levels? Or does it interact with GABA(A)/GABA(B) receptors? I couldn't find any studies on pubmed regarding theanine+gaba, although many websites claim that theanine increases both dopamine and gaba levels (the dopamine increase however is well documented, and the glutamate NDMA antagonism effect too). I'd appreciate if you have any sources on this aspect.Take care.
Posted by Larry Hoover on October 11, 2003, at 6:43:04
In reply to Larry-do you know of any evidence on L-Theanine..., posted by btnd on October 11, 2003, at 5:48:57
> Hi,
> Do you know of any evidence on L-Theanine increasing GABA brain levels? Or does it interact with GABA(A)/GABA(B) receptors? I couldn't find any studies on pubmed regarding theanine+gaba, although many websites claim that theanine increases both dopamine and gaba levels (the dopamine increase however is well documented, and the glutamate NDMA antagonism effect too). I'd appreciate if you have any sources on this aspect.
>
> Take care.Sorry, I can't find one whit of confirmatory evidence for a link to GABA, although the structure of theanine could conceivably be converted to GABA. I say conceivably, as that is *pure* speculation.
What is interesting in that theanine is a caffeine antagonist. I didn't know that. I love questions. Got any more? ;-)
Lar
Posted by tealady on October 11, 2003, at 7:58:04
In reply to Larry-do you know of any evidence on L-Theanine..., posted by btnd on October 11, 2003, at 5:48:57
There is some kinda link between glutamate and GABA though errrr...
I think
http://jn.physiology.org/cgi/content/full/82/1/94
"In the mature nervous system excitatory neurotransmission mediated by glutamate is balanced by the inhibitory actions of GABA"http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=12904482&dopt=Abstract
"Department of Neuroscience, Merck Research Laboratories, West Point, Pennsylvania 19486-0004, USA.The globus pallidus (GP) is a key GABAergic nucleus in the basal ganglia (BG). The predominant input to the GP is an inhibitory striatal projection that forms the first synapse in the indirect pathway. The GP GABAergic neurons project to the subthalamic nucleus, providing an inhibitory control of these glutamatergic cells. Given its place within the BG circuit, it is not surprising that alterations in GP firing pattern are postulated to play a role in both normal and pathological motor behavior. Because the inhibitory striatal input to the GP may play an important role in shaping these firing patterns, we set out to determine the role that the group III metabotropic glutamate receptors (GluRs) play in modulating transmission at the striatopallidal synapse. In rat midbrain slices, electrical stimulation of the striatum evoked GABA(A)-mediated IPSCs recorded in all three types of GP neurons. The group III mGluR-selective agonist L-(+)-2-amino-4-phosphonobutyric acid (L-AP4) inhibited these IPSCs through a presynaptic mechanism of action. L-AP4 exhibited high potency and a pharmacological profile consistent with mediation by mGluR4. Furthermore, the effect of L-AP4 on striatopallidal transmission was absent in mGluR4 knock-out mice, providing convincing evidence that mGluR4 mediates this effect.
The finding that mGluR4 may selectively modulate striatopallidal transmission raises the interesting possibility that activation of mGluR4 could decrease the excessive inhibition of the GP that has been postulated to occur in Parkinson's disease.
Consistent with this, we find that intracerebroventricular injections of L-AP4 produce therapeutic benefit in both acute and chronic rodent models of Parkinson's disease"
probably no help ..
Jan
Posted by jparsell82 on October 11, 2003, at 13:49:08
In reply to Re: Gluatamate and Gaba » btnd, posted by tealady on October 11, 2003, at 7:58:04
L-Pyroglutamate also has anxiolytic effects. It improves my verbal fluency also. I think it's works through the GABA system in some way. It's also structurally similar to Piracetam(smart drug).
Posted by Ame Sans Vie on October 15, 2003, at 18:34:49
In reply to Re: Gluatamate and Gaba, posted by jparsell82 on October 11, 2003, at 13:49:08
Pyroglutamate is anxiolytic -- really? I had chalked it up as the ingredient in a recently sampled GHB substitute that had me feeling overstimulated. Perhaps I should give it a shot on its own. Maybe I jumped to conclusions as it has the dreaded (dreaded by me) "glutamate" in its name.
Posted by jparsell82 on October 17, 2003, at 15:15:19
In reply to Re: Gluatamate and Gaba » jparsell82, posted by Ame Sans Vie on October 15, 2003, at 18:34:49
> Pyroglutamate is anxiolytic -- really? I had chalked it up as the ingredient in a recently sampled GHB substitute that had me feeling overstimulated. Perhaps I should give it a shot on its own. Maybe I jumped to conclusions as it has the dreaded (dreaded by me) "glutamate" in its name.
That's what I read from "Smart Drugs". That it was similar to Piracetam in that it improved learning but it also had mild anxiolytic effects.
Posted by Ame Sans Vie on October 17, 2003, at 21:35:29
In reply to Re: Gluatamate and Gaba, posted by jparsell82 on October 17, 2003, at 15:15:19
Cool... thanks for the heads up! Guess I got a little reading to do...
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