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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 4 of 4. This is the beginning of the thread.
Posted by linkadge on December 2, 2020, at 16:26:37
Have you ever combined a DAT inhibitor with a MAO-B inhibitor? If so, what effects did you have?
Linkadge
Posted by undopaminergic on December 2, 2020, at 17:26:17
In reply to for undopaminergic, posted by linkadge on December 2, 2020, at 16:26:37
> Have you ever combined a DAT inhibitor with a MAO-B inhibitor? If so, what effects did you have?
>
> LinkadgeI don't remember whether I ever took methylphenidate while I was on selegiline, but I think I must have tried at some point, because I was doing everything I could to boost my dopamine pharmacodynamically in those days. Had I had any kind of notable effect, I would probably remember it. That's not to say it couldn't be a potentially worthwhile and synergistic combination for someone else.
What I do remember, however, is that I was using-abusing phenylethylamine (PEA) while on selegiline. That was a very potent combination, even for me. We can probably infer that substituting a DAT-inhibitor for the DA-releaser would result in a less potent combination.
-undopaminergic
Posted by linkadge on December 3, 2020, at 16:04:37
In reply to Re: for undopaminergic, posted by undopaminergic on December 2, 2020, at 17:26:17
Thanks for sharing.
Also, have you found (if applicable) that reuptake inhibitors (like methlyphenidate, ethylhpenidate or cocaine) block the effect of amphetamines in any way?
I read that, in some paradigms (in mice at least) methlyphendiate can block some of the effects of amphetamines.
Linkadge
Posted by undopaminergic on December 4, 2020, at 0:26:44
In reply to Re: for undopaminergic, posted by linkadge on December 3, 2020, at 16:04:37
> Thanks for sharing.
>No problem.
> Also, have you found (if applicable) that reuptake inhibitors (like methlyphenidate, ethylhpenidate or cocaine) block the effect of amphetamines in any way?
>I never tried that combination.
> I read that, in some paradigms (in mice at least) methlyphendiate can block some of the effects of amphetamines.
>Cocaine does (in animals at least), so probably methylphenidate too. This is a direct result of their primary mechanism of action, to inhibit the DAT, which amphetamines (and PEA) depend upon to get taken into the nerve terminals where they can exert their neurotransmitter-releasing actions. It is probably dose dependent, and remember that higher (equivalent) doses are typically used in animal studies. I have often seen claims that in humans, the effects of cocaine plus amphetamines, are additive. While that seems to be an assumption (possibly erroneous), I think there is a possibility for it at lower cocaine doses.
On another note, the amphetamine-like stimulants have a more severe withdrawal. They made me feel drained of energy for months or years on end after quitting. It is important to note, however, that I used PEA long term. I think this was due to neurotoxicity comparable to that associated with methamphetamine, because it was worse than before I started the drug.
Meanwhile, for me, the reuptake inhibitor withdrawal lasted a night or at most a few days.
-undopaminergic
This is the end of the thread.
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