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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 13 of 13. This is the beginning of the thread.
Posted by rakesh on January 22, 2016, at 4:39:23
am male 24 .in my teens I had mastur**** habits .Unfortunately I lost my sensation of my body.now a very weak sensation controls me.sir I felt that after every orgasm.i used to deplete something .some chemical.which now I feel is dopamine. So the cure would be to get dopamine boost. I have tried tyrosine but it doesn't work.also I feel is that dopamine doesnt get synthesised because of my abnormal sensation.so precursors of dopamine wont work .I need something that is already in final state nd not just precursors.i guess artificial dopamine would work.but im scared because I read that it is given to heart patients of which I don't have any problems.
Posted by Jeroen on January 23, 2016, at 4:19:10
In reply to how to increase dopamine levels artificially, posted by rakesh on January 22, 2016, at 4:39:23
hi i've seen in video about it about artificial dopamine
don't do it, it's to replace dopamine, it propably will cause many dangerous problems
Posted by paulb on January 23, 2016, at 22:03:41
In reply to how to increase dopamine levels artificially, posted by rakesh on January 22, 2016, at 4:39:23
The next step on from L-Tyrosine is L-Dopa(Levodopa)which will certainly be better at increasing dopamine levels than L-TYrosine because it one step closer. Actually Im not sure whether it is in fact pure dopamine and if its not its pretty close for sure. It crosses the blood-brain barrier and i think is used for parkinsons disease so im not sure that would be appropriate for you. Of course there is always the addictive and non addictive medications which both have their pros and cons. Take Wellbutrin, a non addictive medicine by and large(only has weak dopamine releasing properties). That would increase your dopamine levels artificially and ive heard good things about it. Bottom line the addictive meds are more powerful but you risk dependancy and the need to increase the dose after some time. With drugs like WEllbutrin, Venlafaxine etc you ave to watch out for poop-out. I personally wouldnt recommend L-DOPA because of the side effects even though it follows on from your point about L-tyrosine and precursors. Your best bet may be a medicine called Parnate which I myself take. Its a powerful antidepressant with some amphetamine like properties but relatively weak. In case many people have benefitted from it.PB
Posted by rakesh on January 25, 2016, at 4:08:17
In reply to Re: how to increase dopamine levels artificially, posted by paulb on January 23, 2016, at 22:03:41
Can u suggest alter native to parnate which I can buy 4m my own country .I m indian
Posted by paulb on January 26, 2016, at 0:15:17
In reply to Re: how to increase dopamine levels artificially, posted by rakesh on January 25, 2016, at 4:08:17
let me think about it and ill get back to you.
Posted by paulb on January 26, 2016, at 0:21:08
In reply to Re: how to increase dopamine levels artificially, posted by paulb on January 23, 2016, at 22:03:41
can anyone else think of best alternative to parnate i thought maybe modafanil which is quite popular.
Posted by SLS on January 26, 2016, at 8:42:26
In reply to Re: how to increase dopamine levels artificially, posted by rakesh on January 25, 2016, at 4:08:17
What are your most urgent symptoms?
Is Emsam (transdermal selegiline) available. It has the ability to act somewhat like Parnate, but is selective for dopamine at low dosages. At higher dosages, it acts a little more like Parnate and helps with norepinephrine and serotonin. Emsam is better for anxiety disorders - particularly social anxiety - but less effective for depression. You won't know until you try it, though.
I would consider combining lamotrigine (Lamictal) with bupropion (Wellbutrin). If that helps, but you need more, you can then add aripiprazole (Abilify). You might then consider a stimulant.
Is pemoline (Cylert) available in India? Pemoline is a pure dopamine releaser used for ADHD. It is no longer sold in the USA.
So there is my answer to your question.
My question to you is, why do you feel the need to focus on drugs with direct effects on dopamine neurons?
Some antidepressants increase dopamine in important areas of the brain downstream from their direct effect. For example, fluoxetine (Prozac), a SSRI, results in increased dopamine activity in the prefrontal cortex (PFC). Sertraline (Zoloft) does the same thing in the nucleus accumbens.
- Scott
Posted by rakesh on January 30, 2016, at 3:33:43
In reply to can anyone else think of best alt to parnate?, posted by paulb on January 26, 2016, at 0:21:08
Can u help me in believing in parnate giving me dopamine boost when I have a weak and abnormal sensation.
Posted by paulb on January 31, 2016, at 14:04:33
In reply to Re: can anyone else think of best alt to parnate?, posted by rakesh on January 30, 2016, at 3:33:43
Parnate is a strong dopamininergic antidepressant for several reasons which might convince you Firstly it is a MAOI and inhibits the breakdown of dopamine furthermore is selectivity for MAO B(dopamine) is greater than MAO A (serotonin) Furthermore Parnate has special amphetamine like properties which used within the RDA will not cause addiction problems It is a strong dopamine drug.PB
Posted by rakesh on February 7, 2016, at 7:05:49
In reply to Re: can anyone else think of best alt to parnate?, posted by paulb on January 31, 2016, at 14:04:33
normal blood concentration of tyrosine is adequate to sustain the increased synthesis, and precursor availability is not a limiting factor. (e) These results suggest that some of the basic concepts about the neurochemical/neurophysiological regulation of monoaminergic neurones may require further reevaluation.
I read this article by author toffano g.i feel me not having normal and complete sensation.lack of dopamine and this article are related.
I tried to contact the author but failed.please if someone can help .
Furthermore can someone professional Interpret it and cure mei have a few days after which my dad will retire and I m unable to do job because of my health conditions.someone please help me or guide me.
Posted by rakesh on February 7, 2016, at 7:37:37
In reply to Re: can anyone else think of best alt to parnate?, posted by paulb on January 31, 2016, at 14:04:33
Regulation of the synthesis and metabolism of striatal dopamine after disruption of nerve conduction
in the medial forebrain bundle.
Commissiong JW1, Slimovitch C, Toffano G.
Author information
Abstract
1. After physical (knife-cut) or chemically-mediated (tetrodotoxin 300 nM, 1.5 microliters; 1.0microliters min-1) interruption of nerve conduction in the nigrostriatal tract, there was a
marked increase in the synthesis and metabolism of dopamine in the isolated dopaminergic nerveterminals of the striatum. The effect peaked at 4 h post-transection, at which time 3,4-
dihydroxyphenylacetic acid (DOPAC) and homovanillic acid (HVA) were increased by 300% and 700%
respectively (DOPAC: 27 +/- 13 vs 80 +/- 17 nmol g-1; HVA: 6.66 +/- 3.57 vs 54 +/- 18 nmol g-1). The
increases in dopamine content and metabolism are secondary to an increase in the rate of synthesis on
the lesioned side, versus the intact, control side. 2. In both experimental situations, haloperidol (1.0
mg kg-1, i.p.)
retained its known ability to induce a significant increase in DOPAC and HVA in the striatum, despitethe interruption of nerve conduction in the nigrostriatal tract. 3. Six days after cutting the left
nigrostriatal tract, dopamine in the left striatum was reduced to less than 5% of the control value, and
DOPAC and HVA were not detectable. In the denervated, left striatum, the synthesis of dopamine
(from injected L-DOPA), and its metabolism to DOPAC and HVA, occurred to the same degree as in the
intact right side. In these DOPA-treated rats, haloperidol (1.0 mg kg-1, i.p.) caused a further increase in
DOPAC and HVA in the
intact striatum, but not in the denervated striatum. 4. Under non-stressful conditions, using acombination of anaesthetic treatments, electrical stimulation (400 muA, 0.4 ins, 15 Hz, 15 min) of the
nigrostriatal tract did not increase DOPAC or HVA in the striatum on the stimulated side. 5. It is
concluded (a) that there is a significant presynaptic, and/or local circuit mechanism capable of
activating the synthesis and metabolism of dopamine in the isolated, striatal, dopaminergic nerve
terminals. Furthermore, haloperidol can act directly on the striatal, dopaminergic nerve terminal, to
cause an increase in
the synthesis and metabolism of striatal dopamine. (b) After degeneration of the striatal dopaminergicnerves, the denervated striatum retains the ability to synthesize (from L-DOPA) and metabolize
dopamine, to the same degree as the intact, innervated, contralateral striatum. (c) When stress is
minimized, and release of dopamine is induced by electrical stimulation of the medial forebrain
bundle, the catabolism of dopamine (to DOPAC and HVA) during the release-uptake cycle may not be a
significant factor under physiological conditions. (d) When dopamine synthesis is increased in the
striatum, the
normal blood concentration of tyrosine is adequate to sustain the increased synthesis, and precursoravailability is not a limiting factor. (e) These results suggest that some of the basic concepts about the
neurochemical/neurophysiological regulation of monoaminergic neurones may require further
reevaluation.
I read this article by author toffano g.i feel me not having normal and complete sensation.lack of
dopamine and this article are related.
I tried to contact the author but failed.please if someone can help .
Furthermore can someone professional Interpret it and cure mei have a few days after which my dadwill retire and I m unable to do job because of my health conditions.someone please help me or guide
me.i dont know what to do.
Posted by rakesh on February 7, 2016, at 8:38:03
In reply to Re: can anyone else think of best alt to parnate?, posted by paulb on January 31, 2016, at 14:04:33
normal blood concentration of tyrosine is adequate to sustain the increased synthesis, and precursor availability is not a limiting factor. (e) These results suggest that some of the basic concepts about the neurochemical/neurophysiological regulation of monoaminergic neurones may require further reevaluation.
I read this article by author toffano g.i feel me not having normal and complete sensation.lack of dopamine and this article are related.
I tried to contact the author but failed.please if someone can help .
Furthermore can someone professional Interpret it and cure mei have a few days after which my dad will retire and I m unable to do job because of my health conditions.someone please help me or guide me.
Posted by Lamdage22 on February 13, 2016, at 8:44:50
In reply to Re: can anyone else think of best alt to parnate?, posted by rakesh on January 30, 2016, at 3:33:43
Parnate can give you a good dopamine boost. So can Emsam. Nardil maybe a tad less than Parnate.
I dont think Maoi can be matched by taking something else.
What speaks against Parnate?
My guess is it is the best for Dopamine.
I dont like recommending addictive substances like Adderall.
This is the end of the thread.
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