![[dr. bob]](/dr-bob-sm.gif)
Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 12 of 12. This is the beginning of the thread.
Posted by KingLeo8 on January 5, 2016, at 16:30:14
Hey guys,
I am using morphine 30mg sustained release tablets for an injury and I found it to be the most miraculous anxiolytic, antidepressant and smart drug that I have ever used. I have used Effexor XR for the past 20 years for depression. I also use Lamictal for my mood instability and then Lyrica and Dormonoct (loprazolam) 2mg for sleep.
The first day I started on the morphine it did what even the most powerful mood cocktails have failed to do. It solved every psychological and physical issue I experience. I won't get into all of the benefits, but I will say this is as close to perfectly normal as I have ever felt.
I would like to know why safer opiates are not used in the treatment of depression!? If they are, then which ones? Is anyone currently using any opiates, including morphine, for the treatment of depression?
I look forward to hearing from you guys.
NB: I AM FULLY AWARE OF THE ADDICTIVE NATURE OF MORPHINE AND THE OPIATES. I DO NOT NEED LECTURES OR ETHICAL OPINIONS ON THE USE THEREOF. THIS POST IS FOR CONSTRUCTIVE INFORMATION AND OPINIONS ONLY.
Posted by paulb on January 5, 2016, at 17:02:17
In reply to Why is morphine such a good antidepressant?, posted by KingLeo8 on January 5, 2016, at 16:30:14
Ive heard Tramadol has some antidepressant properities similar to conventional antidepressants but still might worth be giving a go. Regards Morphine its a good and powerful drug and has helped many but the only opiate i can think of that has AD properties is tramadol-noradrenaline and serotonin related, if you wanted to stick to te morphine or stronger opiates ive heard hydromorphine is even more powerful but has less bioavailability than morphine. Just a question for you does Sustained Release forms of a drug render it less addictive or does it just keep a steady level in your blood stream.
Posted by Christ_empowered on January 5, 2016, at 18:32:27
In reply to Why is morphine such a good antidepressant?, posted by KingLeo8 on January 5, 2016, at 16:30:14
I seem to recall reading somewhere that opiates were used for depression for a long, long time. The last mention of it in the psychiatric literature (before the current flurry of interest in Suboxone) was in the 50s or so, if I remember correctly.
Some AD drugs have some effects on opiod systems in the brain...something like that. Its one reason some TCA drugs work better for severe depression than, say, Prozac.
I dunno. I vaguely recall reading about a potent opiate being used in treatment resistant schizophrenia, to good effect. When I had an Rx for vicodin w/ a couple refills, I found that even low doses elevated my mood and also made me care less about things. Sort of like a fast acting, super Antidepressant...plus the euphoria, of course.
I can't blame you for liking the morphine. I mean...with all the overpriced, under-performing drugs on the market, its crazy that something as old as good ole morphine can outperform our modern meds. Sad statement on psychiatry and Big Pharma, I think.
Good luck.
Posted by baseball55 on January 5, 2016, at 20:14:35
In reply to Re: Why is morphine such a good antidepressant?, posted by Christ_empowered on January 5, 2016, at 18:32:27
Morphine, oxycodone, heroin. Nothing like them for generating a feeling of emotional well-being. I self-medicated with oxycodone for five years. I became depressed only when I stopped. BUT - tolerance is a BIG problem. That's a major reason I stopped. They stop working unless you take higher and higher doses and at higher and higher doses, potential for overdose and respiratory failure gets higher and higher as well. Now maybe you can find a doctor who can titrate your doses gradually as you build tolerance and maybe you, unlike me, can stick to your doctor's schedule and not try to enhance the feeling of well-being by upping the dose. This is assuming you can find a doctor who will prescribe opiates when no physical pain is present and who will not worry about being audited by the FDA when they continue prescribing year after year.
I don't want to get all ethical on you, but for people with psychic pain, the tendency to abuse opiates (not take as directed) is almost irresistible. Also, watch out for the withdrawal if you have to stop. You will experience a rebound depression like nothing you have ever felt before.
Posted by rjlockhart37 on January 5, 2016, at 21:38:32
In reply to Why is morphine such a good antidepressant?, posted by KingLeo8 on January 5, 2016, at 16:30:14
people, dating back to the 1800's reported "wellbeing"
i'm not an expert at all on opiates, but they do produce just feeling "ok" everything is alright, and not depressed, i've been on high dose of codeine and hydrocodone from previous surgeries and noticed it's well being feeling
i think it effects the dopamine systems to turn pain into pleasure (not saying pleasure as getting high) but the opposite of pain, is pleasure .... i read somewhere long ago on google that opiates induce pleasure to combat the pain.......
it works wonders, and yes it is vary effective both in physical pain and psychological
Posted by KingLeo8 on January 7, 2016, at 22:09:56
In reply to Re: Why is morphine such a good antidepressant?, posted by baseball55 on January 5, 2016, at 20:14:35
> Morphine, oxycodone, heroin. Nothing like them for generating a feeling of emotional well-being. I self-medicated with oxycodone for five years. I became depressed only when I stopped. BUT - tolerance is a BIG problem. That's a major reason I stopped. They stop working unless you take higher and higher doses and at higher and higher doses, potential for overdose and respiratory failure gets higher and higher as well. Now maybe you can find a doctor who can titrate your doses gradually as you build tolerance and maybe you, unlike me, can stick to your doctor's schedule and not try to enhance the feeling of well-being by upping the dose. This is assuming you can find a doctor who will prescribe opiates when no physical pain is present and who will not worry about being audited by the FDA when they continue prescribing year after year.
>
> I don't want to get all ethical on you, but for people with psychic pain, the tendency to abuse opiates (not take as directed) is almost irresistible. Also, watch out for the withdrawal if you have to stop. You will experience a rebound depression like nothing you have ever felt before.
Thanks for response. It is very imformative. I also feel that oxycodone as opposed to morphine is the better opiate for depression. Even as the slow release version, OxyContin, it is highly effective. My doctor was telling of ways to reduce tolerance. One of them is taking clonidine daily.I haven't gotten to the point where I am building up tolerance. If I do, then I will definitely take something to keep tolerance at bay. I just figure that it has taken me 20 years to find something almost perfect for my mental illness and I am going respect it and do what I can to sustain the effects. I am beyond grateful that something finally works.
The opiates have literally given me my life back. I was in physical and mental pain daily and now I am completely free of both. My life has changed due to being positive and optimistic and sending out this vibe/frequency. I am more confident, happy and content. This is obviously sensed by other people, both socially and in business environments. It makes positive outcomes much more likely....instead of expecting the worst all the time and getting it.
Posted by KingLeo8 on January 7, 2016, at 22:19:54
In reply to Re: Why is morphine such a good antidepressant?, posted by paulb on January 5, 2016, at 17:02:17
I have used tramadol before and to great effect. I just found that it became ineffective pretty quickly.
With regards Sustained Release versus Immediate Release opiates I find that the SR version keeps a constant blood level and keeps my mood elevated for longer. I have noticed that the IR versions have what I call and "afterglow"....where once the medicaton has worn off after 5 to 6 hours then my mood is still elevated by not as powerfully. That lasts into the next day too.
In terms of becoming addicted to opiates, it's not an issue for me because I just accept that I may become addicted to them. In life everything is a risk vs benefit ratio. In my case the benefits of using opiates to completely eliminate every symptom I have, including suicidal ideation, then its a small price to pay for sanity and an opportunity to feel "normal".
Posted by KingLeo8 on January 7, 2016, at 22:25:02
In reply to Re: Why is morphine such a good antidepressant?, posted by Christ_empowered on January 5, 2016, at 18:32:27
You are right. I wonder why they haven't ventured down the opiate agonist route until now!?I suppose they can not have full treated happy patients strolling around, otherwise it is hard to sell all the crazy add ons we need these days to boost conventional antidepressants.
Posted by baseball55 on January 8, 2016, at 19:59:34
In reply to Re: Why is morphine such a good antidepressant?, posted by KingLeo8 on January 7, 2016, at 22:19:54
Some doctors will prescribe suboxone for depression, rather than oxycodone and morphine derivatives. Suboxone contains naltrexone (oral form of naloxone), an opiate antagonist to prevent overdose and addictive use. It also contain buprenophine, a strong opiate agonist with a long half-life, which makes it somewhat less addictive (though studies are finding that it's hard to get off of suboxone). Methadone is also a long-acting opiate, but it's hard to find a doctor willing or able to prescribe on an out-patient basis.
But if oxycontin works for you, great. It's long acting and, as long as you don't try to override the time-release (which is harder to do than it used to be, but is what addicts do), it is less addictive and easier to withdraw from, should you someday want to stop it.
Posted by KingLeo8 on January 11, 2016, at 21:13:50
In reply to Re: Why is morphine such a good antidepressant? » KingLeo8, posted by baseball55 on January 8, 2016, at 19:59:34
> Some doctors will prescribe suboxone for depression, rather than oxycodone and morphine derivatives. Suboxone contains naltrexone (oral form of naloxone), an opiate antagonist to prevent overdose and addictive use. It also contain buprenophine, a strong opiate agonist with a long half-life, which makes it somewhat less addictive (though studies are finding that it's hard to get off of suboxone). Methadone is also a long-acting opiate, but it's hard to find a doctor willing or able to prescribe on an out-patient basis.
>
> But if oxycontin works for you, great. It's long acting and, as long as you don't try to override the time-release (which is harder to do than it used to be, but is what addicts do), it is less addictive and easier to withdraw from, should you someday want to stop it.
Thanks for your response mate.Here in South Africa we have a product called Subutex which is just pure buprenorphine. I have read up quite a bit on buprenorphine and its claimed ability to have a profound effect on depression. I also tried it for a month.
I believe I gave it a fair chance to work but I had no positive effects from it whatsoever.
Hopefully with new studies on the opiates and their receptors, Big Pharma will find something that gives people back the joy they have lost and are seeking again. I do feel that they have a very Calvinistic approach to humanity and it's suffering though. This is obvious by the amount of truly effective dopaminergic medications for depression. They are none and the USA seems to be able to dictate on global scale who is allowed to produce these medications or not. In this case I am refering to Amineptine. By the looks of it a one world government started after WWII. It is not waiting for us on the horizon. It already here and has been here for a long time.
Big Pharma seems to avoid creating feelings of true well being at all cost. I have never been able to answer this question. This is why I stuck my neck and said that the only two pharmaceuticals ever to relieve my depression from the outset are the opiates morphine and oxycodone.....both in slow release formulations.
Posted by Lamdage22 on January 18, 2016, at 3:41:31
In reply to Re: Why is morphine such a good antidepressant?, posted by KingLeo8 on January 11, 2016, at 21:13:50
i am not a fan of this treatment.
I dont believe in doing addictive drugs.
Posted by Lamdage22 on January 18, 2016, at 3:43:37
In reply to Re: Why is morphine such a good antidepressant?, posted by Lamdage22 on January 18, 2016, at 3:41:31
i stopped taking lorazepam. I feel my baseline anxiety increases if i take it.
This is the end of the thread.
Psycho-Babble Medication | Extras | FAQ
Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.org
Script revised: February 4, 2008
URL: http://www.dr-bob.org/cgi-bin/pb/mget.pl
Copyright 2006-17 Robert Hsiung.
Owned and operated by Dr. Bob LLC and not the University of Chicago.