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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 6 of 6. This is the beginning of the thread.
Posted by uncouth on March 10, 2014, at 13:49:39
Hi, haven't posted in a while!
Can someone help me understand the diffferences in effect, side effects, and pharmacology between nardil and marplan?
Have tried nardil and parnate and emsam in the past but at times of very very severe depression which nothing much was helping. Doing much better now but still dealing with residual depression (Bipolar2) and mostly a lot of social disinterest. Was hoping nardil's gaba and especially it's phenylethylamine metabolite properites would help. I had a profound initial positive effect to PEA taken with an MAOB a few years back, but it rapidly turned into a very very bad destructive dependence.
Considering nardil and we are on track to start it later this week but curious if I should do more research on Marplan. Does anything make it special?
(I'm afraid of weight gain...)
Posted by PeterMartin on March 11, 2014, at 1:23:57
In reply to Marplan vs. Nardil, posted by uncouth on March 10, 2014, at 13:49:39
I take Marplan and haven't had issues with weight gain. I've been taking it since 2010 (so about 4yrs now). I've gained about 20lbs over that time (6'0 - 215lbs - 36yrs now) but I've also taken seroquel and I'm not a particularly healthy eater/exerciser.
That said I think it's much more mild than the others. My life got better when I started taking it so I haven't needed to change courses. I know a few around here have tried Marplan and felt it didn't help the way Nardil does.
Hopefully someone with a recent trial of both could give you more info. Just wanted to say I haven't had weight gain problems.....
Good luck.
Posted by kirkglen on March 21, 2014, at 8:57:18
In reply to Re: Marplan vs. Nardil, posted by PeterMartin on March 11, 2014, at 1:23:57
I've been on Nardil for 30+ yrs. 2003 it's formula was changed and the success lessened. I tried everything else to no avail and finally have returned to Nardil. I feel the problem is I'm absorbing in the stomach. It's design was for the small intestine.
Today I'm doing much better after trying different methods to move the absorption.
If your going to use Nardil this is my opinion:1. Take Nardil on an empty stomach with 12 oz. H2O
2. Ask your Pdoc to mandate you receive your pills in the 60 pill sealed bottle. It has a desiccant in it to keep moisture from attacking the chemical that moves absorption .Greenstone is the supplier.
3. Do not eat sweets. I do not understand the chemistry but sweets totally negate Nardil in my body.
4. Find a good B complex and take daily.On a very positive note my doc tells me Nardil is making a comeback and in his opinion it's the best AD on the market. He's 83 yrs. old.
Posted by uncouth on March 21, 2014, at 12:01:32
In reply to Re: Marplan vs. Nardil, posted by kirkglen on March 21, 2014, at 8:57:18
Thanks for the reply. I will hopefully be starting nardil monday.
I'm a bit worried as I also take Victoza for prediabetes, and it substantially slows gastric emptying (so one feels fuller all the time).
I wonder if anyone has explored somehow coating nardil in something, to get it to make it to the intestines? Or asking a compounding pharmacy to do that. Any idea? I had heard around PB people say "Nardil changed" but didn't quite understand how one couldn't just adjust the dose higher to make up for this...
What dose do you take it at, and have you had any side effects over the long term? Fatigue, weight gain, sleepyness, etc.? Does it feel "clean"?
Thanks
Posted by kirkglen on March 22, 2014, at 12:30:19
In reply to Re: Marplan vs. Nardil, posted by kirkglen on March 21, 2014, at 8:57:18
The pre-2003 pill had a pharm glaze and a wax coating that moved the pill to the small intestine. The current formula uses Croscarmellose Sodium
which unfortunately dissolves in H20. Every time you open your bottle the pill is exposed to whatever the dewpoint is..That is the reason I would mandate the 60 pill bottle with the desiccant. Taking on an empty stomach with water should move the pill quickly through the stomach.
If you can afford having your pills made that would be great.
As to the dosing when I first started Nardil I did run up to 90mg in AM to get it to kick in. At that time hypertension and difficulty in urinating were my only side effects.I have found to high of a dose actually increases my depression and brings about diarrhea.
Posted by kirkglen on March 22, 2014, at 12:42:41
In reply to Re: Marplan vs. Nardil, posted by kirkglen on March 22, 2014, at 12:30:19
Ineffective Drug or Supplement Delivery
Croscarmellose sodiums ability to expand and absorb fluids makes it an ideal vehicle for drug and supplement delivery. However, if medicines and supplements with croscarmellose sodium are left out of their containers, they will also absorb moisture from the air, states AAPS PharmSciTech. This could cause the drug to be released in your stomach instead of your intestines. If the drug is released prematurely, you may not absorb the correct dose. If your medicine has become exposed to moisture, talk to your doctor about getting a replacement prescription.
This is the end of the thread.
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