Psycho-Babble Medication Thread 1060040

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Re: Wrong about mental illness. » herpills

Posted by SLS on February 3, 2014, at 8:37:34

In reply to Re: Wrong about mental illness. » SLS, posted by herpills on February 2, 2014, at 13:54:24

>
> >
> > > How do you know?
> >
> > Exposure.

Exposure to a bunch of different doctors in several different venues. I've been treated by local doctors, doctors at major universities, teaching hospitals, and at the NIH.

> > > What makes them great?

> > What criteria in particular would you like for people to rate psychiatrists on?

> I'm not sure, one reason why I brought it up!

Okay, yes. You are right.

I don't know how to answer that. Of course, having a track record of successfully treating people is one criterion. Compassion and attentiveness. Insight into what it is like to experience mental illness - knowing how intensely painful and unrelenting it can be. Able to keep up with the latest research and clinical diagnostic and treatment strategies. Willing to take on challenging cases and motivated to research and confer with colleagues. Has a good foundation in medicine and understands the body as an integrated system. Willing to explore treatments that are aggressive and unconventional. Unafraid to use MAOIs and combine them other drugs. Unafraid to refuse the use of treatments that he believes are unsafe or counterproductive, despite the pleadings of his patients. Willing to listen to patients and respect their intelligence and knowledge. Understands that drugs can make someone feel worse instead of better - that suicide can be the ultimate side effect. Monitors a patient closely during the first three weeks of treatment when suicidality is most likely. Spends more than 5 minutes interacting with and evaluating a patient on follow-up visits. Willing to suggest to a patient that they seek a second opinion or consultation with another doctor when the strategies tried are inadequate. Understands the dynamics between the biological and psychological and appreciates the value of psychotherapy. Refuses to tell a patient that they are untreatable. Aappreciates the number of permutations possible of drugs when they are combined. Knows the pharmacology of drugs in addition to their clinical characteristics.

These are a few of my favorite things...


- Scott

 

Re: Wrong about mental illness. Phidippus

Posted by poser938 on February 3, 2014, at 11:51:57

In reply to Re: Wrong about mental illness. Phidippus » poser938, posted by phidippus on February 2, 2014, at 23:30:42


>
> But can they make you permanently depressed? No. That would take some major alterations to brain structure.
>
> What antidepressants have you been on?
>
> Eric

How do you know this?

But, if you lack the understanding into, at least the possibility of how Psychiatric Chemicals can cause a situation like mine, I don't believe advice from you based on past meds I've tried could be helpful.

 

Re: Wrong about mental illness. » SLS

Posted by Bob on February 3, 2014, at 12:00:49

In reply to Re: Wrong about mental illness. » herpills, posted by SLS on February 3, 2014, at 8:37:34

Unafraid to use MAOIs and combine them other drugs. Unafraid to refuse the use of treatments that he believes are unsafe or counterproductive, despite the pleadings of his patients. Willing to listen to patients and respect their intelligence and knowledge. Understands that drugs can make someone feel worse instead of better - that suicide can be the ultimate side effect. Monitors a patient closely during the first three weeks of treatment when suicidality is most likely. Spends more than 5 minutes interacting with and evaluating a patient on follow-up visits. Willing to suggest to a patient that they seek a second opinion or consultation with another doctor when the strategies tried are inadequate. Understands the dynamics between the biological and psychological and appreciates the value of psychotherapy. Refuses to tell a patient that they are untreatable. Aappreciates the number of permutations possible of drugs when they are combined. Knows the pharmacology of drugs in addition to their clinical characteristics.
>
> These are a few of my favorite things...
>
>


Scott:

What area of the country are you in? I might consider looking for a pdoc that would consider the MAOI treatment along with nortriptline and possible augmentation with dopaminergic drugs as well on occasion. He has been a relatively good doc for me though and meets just about all the other criteria you've mentioned in your description. And I've been seeing him for almost 20 years. It would be a big change for me.

I'm also not sure how I would find a pdoc that I knew was willing to try before I've even seen him or her. Seems kind of weird to ask someone that as a pre-screening req.

Bob

 

Re: Wrong about mental illness. Phidippus » poser938

Posted by phidippus on February 3, 2014, at 12:50:24

In reply to Re: Wrong about mental illness. Phidippus, posted by poser938 on February 3, 2014, at 11:51:57

How do you know the meds permanently changed your brain function?

Son, you're on a high horse, convinced this is what's happened to you. You come to this board to bitch about it and reject all offers for help. Keep ranting about it and its going to get you nowhere.

You're obsessed with the idea medication caused you brain damage. Just get it out of your f*ck*ng mind and maybe you'll be able to move forward.

Eric

 

Re: Wrong about mental illness. Phidippus

Posted by poser938 on February 3, 2014, at 13:00:06

In reply to Re: Wrong about mental illness. Phidippus » poser938, posted by phidippus on February 3, 2014, at 12:50:24

I know this for the dame basic reason anyone knows how any Med they've taken affected them.

I come here for advice on my situation as well as discuss psychiatric meds.
I routinely have you and a few others discredit my experiences when I post on here. I appreciate posts by those who have an open mind.

 

Re: Wrong about mental illness. Phidippus » poser938

Posted by phidippus on February 3, 2014, at 13:08:02

In reply to Re: Wrong about mental illness. Phidippus, posted by poser938 on February 3, 2014, at 13:00:06

Yet you don't have an open enough mind to discuss your past therapies with me. Weird.

Why can't it simply be your illness that worsened?

Eric

 

Re: Wrong about mental illness. Phidippus

Posted by poser938 on February 3, 2014, at 13:14:33

In reply to Re: Wrong about mental illness. Phidippus, posted by poser938 on February 3, 2014, at 13:00:06

I wasn't exactly trying to be rude. But if some of routinely discredited and demean the experiences of a certain visitor to this sight, then how would you expect this person to reply, Eric?

You need yo accept that there are roughly 7 billion people on this Earth with different Genetic Make-Ups. Not all of them are going to react to putting a foreign chemical that sneaks past their blood brain barrier in a routine way.

And I find it incredibly ironic how people on this site who recognize and have experienced the stigma of Depression. And how many others just do not understand it, because it differs from the norm. But it is ironic, how many of these same people
turn around and look at me the same as ways as those with healthier minds look at them.

You meed to get off your high horse, Eric. If you didn't notice, I began describing my situation to you seeking advice until you discredited my experience.

 

Re: Wrong about mental illness. Phidippus

Posted by poser938 on February 3, 2014, at 13:17:13

In reply to Re: Wrong about mental illness. Phidippus » poser938, posted by phidippus on February 3, 2014, at 13:08:02

> Yet you don't have an open enough mind to discuss your past therapies with me. Weird.
>
> Why can't it simply be your illness that worsened?
>
> Eric

I'd be wasting my time telling you about my past experiences after you discredit my experience.

And its simply not just that my illness worsened.


Anyways, I gotta get off here.

 

Re: Wrong about mental illness. Phidippus » poser938

Posted by SLS on February 3, 2014, at 17:05:47

In reply to Re: Wrong about mental illness. Phidippus, posted by poser938 on February 3, 2014, at 13:17:13

I would not be so quick to discredit your experiences. I am convinced that exposure to some psychiatric drugs results in changes in brain function that can persist after they are discontinued.

How is your condition different now compared to before drug treatment? Which drugs do you feel are most responsible for these changes?

It is important to note that Major Depressive Disorder (MDD) tends to get worse over time in untreated individuals. It also has a tendency to morph in a way where melancholic thoughts recede and cognitive impairments predominate. I believe that when MDD first emerges in late-life, it also looks a lot like dementia.

1. How old are you?

2. At what age did MDD appear?

3. What was the course of your illness before treatment? Was it chronic or recurrent?

4. Are there any first-degree relatives with depression, bipolar disorder, or schizoid disorder?


- Scott

 

Re: Wrong about mental illness. » Bob

Posted by SLS on February 3, 2014, at 17:26:48

In reply to Re: Wrong about mental illness. » SLS, posted by Bob on February 3, 2014, at 12:00:49

> What area of the country are you in?

Near New York City.

I like Columbia / New York State Psychiatric for working with aggressive therapies using MAOIs. I have been seen by several doctors there. Patrick McGrath might be a good one to ask for.

http://asp.cumc.columbia.edu/facdb/profile_list.asp?uni=pjm5&DepAffil=Psychiatry

http://columbiapsychiatry.org/researchclinics/depression-evaluation-service


- Scott

 

Re: Wrong about mental illness. Phidippus

Posted by phidippus on February 3, 2014, at 18:16:46

In reply to Re: Wrong about mental illness. Phidippus, posted by poser938 on February 3, 2014, at 13:14:33

>I began describing my situation to you seeking advice until you discredited my experience.

I can only advise you if YOU keep an open mind. You are absolutely convinced medication caused your illness and won't look at it any other way.

My big question is: If medication has brought you so much ill, why do you insist on visiting med boards? Why not just give up on drugs?

Eric

 

Re: Wrong and Right

Posted by Dr. Bob on February 4, 2014, at 3:37:05

In reply to Re: Wrong about mental illness. Phidippus, posted by phidippus on February 3, 2014, at 18:16:46

> > I began describing my situation to you seeking advice until you discredited my experience.
>
> I can only advise you if YOU keep an open mind. You are absolutely convinced medication caused your illness and won't look at it any other way.

Could I call a time-out?

1. If one poster has a bad experience with psychiatry, that doesn't mean psychiatry is always wrong. Just like if another poster has a good experience with psychiatry, that doesn't mean psychiatry is always right. Neither's experience discredits the other's.

2. A discussion is more likely to be productive if both "sides" keep an open mind. Maybe medication didn't cause someone's illness. But maybe it did.

3. The goal here is to be supportive, not to be right.

> My big question is: If medication has brought you so much ill, why do you insist on visiting med boards? Why not just give up on drugs?

Maybe they have an open mind. One bad experience, or even a string of them, doesn't mean their next experience won't be good. Hope springs eternal.

Bob

 

Re: Wrong and Right » Dr. Bob

Posted by SLS on February 4, 2014, at 5:13:40

In reply to Re: Wrong and Right, posted by Dr. Bob on February 4, 2014, at 3:37:05

> One bad experience, or even a string of them, doesn't mean their next experience won't be good. Hope springs eternal.

Amen to that!


- Scott

 

Re: Wrong about mental illness. » SLS

Posted by Bob on February 4, 2014, at 11:34:14

In reply to Re: Wrong about mental illness. » Bob, posted by SLS on February 3, 2014, at 17:26:48

> > What area of the country are you in?
>
> Near New York City.
>
> I like Columbia / New York State Psychiatric for working with aggressive therapies using MAOIs. I have been seen by several doctors there. Patrick McGrath might be a good one to ask for.
>
> http://asp.cumc.columbia.edu/facdb/profile_list.asp?uni=pjm5&DepAffil=Psychiatry
>
> http://columbiapsychiatry.org/researchclinics/depression-evaluation-service
>
>
> - Scott


Ha! Oddly enough, NYSPI and Columbia is exactly where I went when I was an active DBS participant. I've been to those facilities a number of times. I have not dealt with the individuals you mentioned however. It would be difficult for me to slog up there from the Balto-Wash area in MD for active treatment. It was definitely a stretch when I was active on DBS.

Thanks for the info... I will mull it over.

Bob

 

Re: Wrong about mental illness. » Bob

Posted by SLS on February 4, 2014, at 13:09:50

In reply to Re: Wrong about mental illness. » SLS, posted by Bob on February 4, 2014, at 11:34:14

What about Johns Hopkins?

http://www.hopkinsmedicine.org/psychiatry/specialty_areas/moods/

I bet Kay Redfield Jameson, Ph.D. would suggest a few names to you.

http://www.hopkinsmedicine.org/psychiatry/specialty_areas/moods/expert_team/jamison.html


- Scott

 

Re: Wrong about mental illness. » SLS

Posted by Bob on February 4, 2014, at 19:18:23

In reply to Re: Wrong about mental illness. » Bob, posted by SLS on February 4, 2014, at 13:09:50

> What about Johns Hopkins?
>
> http://www.hopkinsmedicine.org/psychiatry/specialty_areas/moods/
>
> I bet Kay Redfield Jameson, Ph.D. would suggest a few names to you.
>
> http://www.hopkinsmedicine.org/psychiatry/specialty_areas/moods/expert_team/jamison.html
>
>
> - Scott


Thanks for the links Scott. I actually have gone to a one-time consultation twice now at Hopkins, although that was over 10 years ago now. It was with Raymond DePaulo there in the Psychiatry Dept. It provided a little insight but no magic answers for sure. I also actually consulted with a doctor at the University of Maryland Medical Center for awhile as well.

Bob

 

Re: Wrong and Right

Posted by poser938 on February 4, 2014, at 21:20:38

In reply to Re: Wrong and Right, posted by Dr. Bob on February 4, 2014, at 3:37:05

> > > I began describing my situation to you seeking advice until you discredited my experience.
> >
> > I can only advise you if YOU keep an open mind. You are absolutely convinced medication caused your illness and won't look at it any other way.
>
> Could I call a time-out?
>
> 1. If one poster has a bad experience with psychiatry, that doesn't mean psychiatry is always wrong. Just like if another poster has a good experience with psychiatry, that doesn't mean psychiatry is always right. Neither's experience discredits the other's.
>
> 2. A discussion is more likely to be productive if both "sides" keep an open mind. Maybe medication didn't cause someone's illness. But maybe it did.
>
> 3. The goal here is to be supportive, not to be right.
>
> > My big question is: If medication has brought you so much ill, why do you insist on visiting med boards? Why not just give up on drugs?
>
> Maybe they have an open mind. One bad experience, or even a string of them, doesn't mean their next experience won't be good. Hope springs eternal.
>
> Bob

Thank you, Dr. Bob.

 

Scott (pretty long post)

Posted by poser938 on February 4, 2014, at 22:11:14

In reply to Re: Wrong about mental illness. Phidippus » poser938, posted by SLS on February 3, 2014, at 17:05:47

> I would not be so quick to discredit your experiences. I am convinced that exposure to some psychiatric drugs results in changes in brain function that can persist after they are discontinued.
>
> How is your condition different now compared to before drug treatment? Which drugs do you feel are most responsible for these changes?
>
> It is important to note that Major Depressive Disorder (MDD) tends to get worse over time in untreated individuals. It also has a tendency to morph in a way where melancholic thoughts recede and cognitive impairments predominate. I believe that when MDD first emerges in late-life, it also looks a lot like dementia.
>
> 1. How old are you?
>
> 2. At what age did MDD appear?
>
> 3. What was the course of your illness before treatment? Was it chronic or recurrent?
>
> 4. Are there any first-degree relatives with depression, bipolar disorder, or schizoid disorder?
>
>
> - Scott
>

Just turned 26. You know how more and more people are prescribed Antidepressants and other Psychiatric Meds, when medication should have never even been seen as an option for their case? That's me. Its a bit embarrassing to say it, but what
pushed me into taking Psychiatric medication was after getting out of a relationship with my "first love". I was 17 and i had thought I lost everything after we broke up.

But when I went to see a Psychiatrist and was prescribed meds, 4 different meds all at once on my first appointment.(Adderall, Aricept, Cymbalta and Geodon.. I was thinking "My situation isn't THAT bad, definitely not as bad as some people I hear about." I ended up only taking the Cymbalta and Adderall. I also did therapy. And before my first appt with the Therapist, I remember telling my mom "How can this guy just talking to me actually help?" I got my answer after my first appointment. All I
needed was to be shown the errors in my thought processes. I went back for more appointments and continued to benefit from it.

Adder all made me feel hyped up and I don't think I ever noticed an effect from Cymbalta. But as time went by, I ended up having a panic attack. , my first panic attack ever. And from this day is when Psychiatric Meds first had its serious, long-term/permanent effect on me. The next day after the panic attack, I felt bad. I ended up discontinuing the meds and my mood never reverted back to normal. I could no longer spend a whole day in school. I had extreme anxiety, agitation and felt like I was in hell. Weeks, months and then a year went by and my mood never reverted back to how I get before starting meds. And at this time I didn't credit the meds for causing me to feel this way, since I had discontinued them.

So, after a year, I went back to the Psychiatrist and tried more meds. Cymbalta again, then Zoloft, then Wellbutrin and then Effexor. At 75 mugs of Effexor, I noticed a slight effect on my mood, but was insure if it was good or bad. So I asked to raise it to 150mgs. At this dose, I started feeling more agitation. And muscles in my face started tensing up on their own and it was a bit painful. It reminded me of the Tar dive Dyskinesia has read about, but I figured "Only Antipsychotics can cause that". My hair was also falling out and I felt an abnormal sensitivity with my moods being affected by foods I ate. But I kept taking it, and after a few, my emotions went completely blank....

I stopped taking it. After a few weeks, the blankness never went away. So I ended up trying Cyproheptadine to counter this. After a few weeks on it, slowly working up the dose, I suddenly felt much better one morning. Not all the way better, but I guess i felt about 75% myself again. But I still had the effect of my moods being strongly affected by foods I ate.

Anyway, I stopped all meds for over 2 years, hoping I'd go completely back to normal. My life was finally liveable, I never did revert back to my pre meds self.
I went to see a regular doctor. Had many tests done with nothing abnormal showing up. So, I decided on trying Mirapex.felt a slight benefit for a few weeks, then one day BAM, I was back to feeling I was in hell. I stopped taking it, after some weeks my mood never went to feeling better. I then tried Tianeptine and after 10 days it made me even worse. Then tried Ritalin, and after the first dose, this worsening was compounded.

Then onto Cyproheptadine., since it was the only Nev to benefit me ever. After a few days it was clear it was helping me again. But this time MUCH more slowly, with each dose only having a slight effect . But I continued it for about 3 months, having to up the dose after about every 3 days because one dose would stop working. But over time, my mood got better and better and better. Until I got to such a high dose that I could no longer take it. That was 3 years ago, and since I've Bern off it, I've VERY slowly regressed back. I'm STILL regressing a tiny but every day. And I will until I get to how I was before I started it.

Oh, and I forgot to mention that Effexor had made me less able to do anything strenuous. And Mirapex compounded this. To where I can't reach my arms out without becoming weak all over and even more depressed feeling for the rest of the day.
I know my experience might be unheard of by many, but this is just how it as been.

Anyway, I feel I've made this long enough. But that's my main experiences describing why I'm in the state I'm in now.

 

Re: Scott (pretty long post) » poser938

Posted by SLS on February 4, 2014, at 23:02:58

In reply to Scott (pretty long post), posted by poser938 on February 4, 2014, at 22:11:14

Thanks for replying, Poser.

I'll want to read your post again and see if I can help you in some way. I just wanted you to know that I'm not ignoring you.

My initial thoughts regarding your reaction to food is that you are experiencing an imbalance in your autonomic nervous system (too much sympathetic and/or too little parasympathetic). Do you experience mild heart palpitations after a meal? This might be part of any mood / anxiety illness you may have. However, I think it reasonable to believe that this dysautonomia can be precipitated or exaggerated by exposure to medication. I would be curious to know if your reaction to food is reduced when you reduce your intake of carbohydrates - especially refined carbohydrates.

The treatment your first psychiatrist prescribed to you was an abomination. You, of course, should have been prescribed psychotherapy as your initial treatment before moving on to biological treatments.

Any nausea?

Have you ever tried nortriptyline (Pamelor) or mirtazapine (Remeron)?


- Scott

 

Re: Scott (pretty long post)

Posted by poser938 on February 5, 2014, at 17:05:25

In reply to Re: Scott (pretty long post) » poser938, posted by SLS on February 4, 2014, at 23:02:58

Scott, I THINK what you're describing with reactions to food is what a friend of mine has, that he developed after smoking Marijuana. And he does have heart palpitations.

But, I believe what I have is different. Now, my thoughts are quite blurry at the moment, but I'll try describing it as well as I can. And I do believe this is going to sound "alien". But as I said, my increased sensitivity to foods began while taking 150mgs of Effexor. At the same time I experienced hair loss, as well as muscles in my face tensing up on their own. And I believe they're all related to the same pathway.

And after I quit Effexor and began, and after a few weeks I noticed the benefit of Cyproheptadine on my mood. At this time, my hair actually started falling out a bit faster and the effect of food on my mood became even stronger. And the weirdest thing was, I could eat certain foods, such as meat, and as soon as I swallowed it, my hair would begin falling out in gobs. And at this same time, my whole emotion system felt alive again. And as soon as I'd eat or drink something else, the massive hair loss would stop. And my emotions once again were inhibited.
I also noticed, that I could once again feel the effects of Adderall again, after it had just completely stopped working after my panic attack. But Adder all also increased my hair loss. And I had only tried one dose just to see if I could feel the effects of it again. What my theory is, is that Effexor caused a Dopamine Super sensitivity, and that this Super sensitivity caused a dysregulation in other pathways, as well as making me sensitive to foods.
...................................................
But, anyway. With Mirapex. I'm positive it caused the same thing Adder all did. Basically a shut down of my Dopamine System. And I believe Cyproheptadine worked to fix this because of its 5ht2c Antagonism, and how this disinhibits Dopamine release. Like I've mentioned, over stimulation of Neurotransmitter Systems can result in making these systems unresponsive. Especially in my case and others that may be prone to this.

http://en.wikipedia.org/wiki/5HT2C_receptor

I have read about other receptors that pay a role in modulating Dopamine Release. Such as the 5ht1a receptor, so I tried Buspar, and it worsened my situation after a single dose.

I've tried low doses of Amisulpride to block D presynaptic repeptors, and felt no effect from it. I've tried regular doses of a few Atypical Antipsychotics and feel no effect from them. I even had a Pdoc prescribe Flumazenil and experienced zero effect from it. And I no longer feel effects from Adderall. Or from Provigil. Some other meds I've tried that I felt zero effect from were Lamictal and Gabapentin. Ketamine only effects me the same way a high dose of Cough Syrup did. By just making me dizzy.

My main Problem, I do believe is a basic shut down in Dopamine Neuro transmission that was caused by Mirapex. And with this, it is very difficult to help my moods by the foods I eat. What benefits me best is caffeine, like a Coca Cola with a meal consisting of some kind of meat. Refined grains that have been supplemented with B Vitamins make me feel bad. While Whole Grains do not. But my hair no longer falls out faster in response to certain foods, though it still falls out slightly more than it used to. Thankfully its not noticeable.

I know all this is a bit complicated, but its what I've experienced. And I don't know any other way to describe it in detail.

But currently, my idea is to try an SSRI, to kind of stimuluate my Serotonin Receptors, signaling for my brain to in a sense, give my Dopamine System a break. And hopefully it will "wake up" as I take the SSRI chronically.

 

Re: Scott (pretty long post)

Posted by poser938 on February 5, 2014, at 17:25:51

In reply to Re: Scott (pretty long post) » poser938, posted by SLS on February 4, 2014, at 23:02:58

And yes, I've tried Remeron with no benefit. But not Pamelor.

I do realize my situation is complicated. And there may not really be much advice for it.

 

Re: Scott (pretty long post) » poser938

Posted by Phillipa on February 5, 2014, at 18:13:03

In reply to Re: Scott (pretty long post), posted by poser938 on February 5, 2014, at 17:25:51

How is your thyroid? Not that it could cause all this. Phillipa

 

It all makes sense » poser938

Posted by phidippus on February 5, 2014, at 18:22:39

In reply to Scott (pretty long post), posted by poser938 on February 4, 2014, at 22:11:14

> pushed me into taking Psychiatric medication was after getting out of a relationship with my "first love". I was 17 and i had thought I lost everything after we broke up.

So you were depressed.

>4 different meds all at once on my first appointment.

Ridiculous.

> Adder all made me feel hyped up and I don't think I ever noticed an effect from Cymbalta.

How do you know it was the Adderall and not the Cymbalta?

>But as time went by, I ended up having a panic attack. , my first panic attack ever.

This can happen with treatment with Cymbalta.

>The next day after the panic attack, I felt bad. I ended up discontinuing the meds and my mood never reverted back to normal.

Cymbalta put you in a tailspin. It may have even triggered a mixed mood episode, which you never treated properly.

>I had extreme anxiety, agitation and felt like I was in hell.

All of these can be signs of a bipolar mood episode. If Cymbalta triggered a bipolar mood episode then it makes sense you could have remained that way without proper treatment.

> So, after a year, I went back to the Psychiatrist and tried more meds. Cymbalta again, then Zoloft, then Wellbutrin and then Effexor.

None of which seem to be the right medications.

>I asked to raise (Venlafaxine) to 150mgs. At this dose, I started feeling more agitation

More antidepressant + bipolar mood disorder equals agitation.

>And muscles in my face started tensing up on their own and it was a bit painful.

Did you get rhythmic movements of your tongue and/or lips?

>"Only Antipsychotics can cause that".

Some antidepressants can cause tardive dyskensia, however Venlafaxine is not listed as one of those antidepressants.

>my moods being affected by foods I ate.

How were your moods affected?

> But I kept taking it, and after a few, my emotions went completely blank....

Venlafaxine can cause emotional flattening.

>So I ended up trying Cyproheptadine to counter this. After a few weeks on it, slowly working up the dose, I suddenly felt much better one morning.

Cyproheptadine antagonizes a lot of those receptors implicated inn a mixed or manic episode. As you raised the dose, the effect became more apparent-you felt better because your mood was stabilizing.

>I decided on trying Mirapex.felt a slight benefit for a few weeks, then one day BAM, I was back to feeling I was in hell.

Curious you should choose another medication that can cause mania in patients with bipolar disorder. I take you were agitated and anxious and dysphoric?

>I stopped taking it, after some weeks my mood never went to feeling better.

Of course not-if your bipolar you wouldn't have improved without the help of a mood stabilizer.

>I then tried Tianeptine and after 10 days it made me even worse. Then tried Ritalin, and after the first dose, this worsening was compounded.

More drugs that make bipolar disorder worse.


>I've VERY slowly regressed back. I'm STILL regressing a tiny but every day.

This is the nature of bipolar disorder.

> I know my experience might be unheard of by many, but this is just how it as been.

Your's is a complex case, but I think it makes perfect sense. I think you're bipolar and need a mood stabilizer to help you with your moods.

Eric

 

Re: Scott (pretty long post)

Posted by phidippus on February 5, 2014, at 18:28:31

In reply to Re: Scott (pretty long post), posted by poser938 on February 5, 2014, at 17:05:25

Dude, you're bipolar. Read my reply to your other post. You need a mood stabilizer.

And, by the way, Cyproheptadine blocks dopamine receptors.

Eric

 

Re: Scott (pretty long post) » poser938

Posted by SLS on February 5, 2014, at 21:46:20

In reply to Re: Scott (pretty long post), posted by poser938 on February 5, 2014, at 17:05:25

Hey, Poser.

You described your situation well.

A few ideas arranged in no particular order:

* Agomelatine (Vilazadone)? It is a potent 5-HT2c receptor antagonist without affecting the 5-HT2a receptor. This is in addition to stimulating melatonin receptors.

* Nortriptyline (Pamelor)? It combines NE reuptake inhibition with 5-HT2a receptor antagonism. It increases dopamine by stimulating its release.

* Mirtazapine (Remeron)? It combines 5-HT2a/c and 5-HT3 receptor antagonism with presynaptic NE alpha-2 receptor antagonism.

* Nefazodone (Serzone)? It combines 5-HTc receptor antagonism and weak serotonin reuptake inhibition.

* Trazodone (Deseryl)? It combines 5-HTc receptor antagonism and weak serotonin reuptake inhibition. Side effects limit its use, and the mCPP metabolite can produce anxiety and agitation in vulnerable individuals via 5-HT2c agonism.

* Memantine (Namenda)? It produces dopamine release, D2 receptor agonism, and dopamine reuptake inhibition.

* Amantadine (Symmetrel)? It increases dopaminergic activity and acts as an antagonist of the NMDA glutamate receptor.

* Aripiprazole (Abilify)? It acts as a dopamine system stabilizer via dopamine D2/3 receptor partial agonism. It also acts as a 5-HT1a partial agonist and 5-HT2a receptor antagonist.

* Selegiline (Emsam)? It is an irreversible MAO inhibitor that is selective for the MAO-B (dopamine) enzyme at low dosages.

* Tranylcypromine (Parnate)? It is an irreversible and nonselective MAO inhibitor with amphetamine-like properties.


- Scott


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[dr. bob] Dr. Bob is Robert Hsiung, MD, bob@dr-bob.org

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