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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 5 of 5. This is the beginning of the thread.
Posted by alchemy on July 8, 2013, at 12:45:15
I often am sensitive to what I eat, mostly in the mornings. Since starting nortriptyline they seemed to have improved. I see that it does something to histamine. Has anyone experienced this?
Posted by ed_uk2010 on July 14, 2013, at 5:54:55
In reply to Nortriptyline helping allergies?, posted by alchemy on July 8, 2013, at 12:45:15
> I often am sensitive to what I eat, mostly in the mornings. Since starting nortriptyline they seemed to have improved. I see that it does something to histamine. Has anyone experienced this?
Like most tricyclic antidepressants, nortriptyline is an antihistamine.
Amitriptyline and doxepin are particularly potent antihistamines. Desipramine has very little antihistamine activity.
Posted by alchemy on July 14, 2013, at 9:49:27
In reply to Re: Nortriptyline helping allergies?, posted by ed_uk2010 on July 14, 2013, at 5:54:55
> > I often am sensitive to what I eat, mostly in the mornings. Since starting nortriptyline they seemed to have improved. I see that it does something to histamine. Has anyone experienced this?
>
> Like most tricyclic antidepressants, nortriptyline is an antihistamine.
>
> Amitriptyline and doxepin are particularly potent antihistamines. Desipramine has very little antihistamine activity.This has been awesome- i ate breakfast and I don't feel like crap. I have never found a drug that helps hayfever let alone my food sensitivities. And they arent even "true allergies" because I had the skin prick test.
I wonder if one marker of whether one of these tricyclics will help someone's depression would be asking about their allergies. So far nortiptyline has kept me from my really bad phases of depression. That is a freakin miracle. And I've gone through plenty of drug trials over 30 years. I still have depression, but the lower level has been skimmed off (at leadt I'm hoping it continues. I am still holding my breath).
Also...the other day I took a ritalin (which I try and avoid). My food sensitivities were particularly aweful and I didn't want to use my head for a couple of hours. A similar response to a time when I increased my Wellbutrin dosage. I would assume that this might be related to their tinkering with norepinephrine. But it's interesting that serotonin and histamine are linked...?
Posted by ed_uk2010 on July 14, 2013, at 10:21:10
In reply to Re: Nortriptyline - 30 yrs of food allergies, posted by alchemy on July 14, 2013, at 9:49:27
>I wonder if one marker of whether one of these tricyclics will help someone's depression would be asking about their allergies.
I think their activity against depression and their activity against allergies are probably separate. The TCAs have quite a range of actions due to binding to a diverse range of receptors.
Great that you're finding nortriptyline helpful :)
Posted by alchemy on July 15, 2013, at 11:18:50
In reply to Re: Nortriptyline - 30 yrs of food allergies » alchemy, posted by ed_uk2010 on July 14, 2013, at 10:21:10
> >I wonder if one marker of whether one of these tricyclics will help someone's depression would be asking about their allergies.
>
> I think their activity against depression and their activity against allergies are probably separate. The TCAs have quite a range of actions due to binding to a diverse range of receptors.
>
> Great that you're finding nortriptyline helpful :)
>
True, good point.
This is the end of the thread.
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