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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 6 of 6. This is the beginning of the thread.
Posted by Cee on March 22, 2013, at 15:13:05
Hello The name of the place is PCCA. If you google it take the us website
Posted by jono_in_adelaide on March 24, 2013, at 18:13:12
In reply to Buy enteric capsules for nardil, posted by Cee on March 22, 2013, at 15:13:05
Nardil was never enteric coated - why is there this feeling that the new formulation needs to be enteric coated in order to work?
Posted by Tomatheus on March 24, 2013, at 18:44:16
In reply to Re: Buy enteric capsules for nardil, posted by jono_in_adelaide on March 24, 2013, at 18:13:12
Jono_in_adelaide,
What you're saying about Nardil is completely untrue. In the U.S., Nardil had an enteric coating until the formulation was changed in 2003. See this recent post of mine for details:
http://www.dr-bob.org/babble/20130308/msgs/1040076.html
Next, you asked "why is there this feeling that the new formulation needs to be enteric coated in order to work?" My answer to your question is that first, I haven't seen the claim made that Nardil needs to be enteric coated to work for everybody. There are obviously some individuals who respond to the current film-coated version of Nardil, and I have yet to read anything from anybody that disputes this. The idea that an enteric-coated version of Nardil may be both more effective and more tolerable in some individuals than the current film-coated version of the medication is based on the fact that many individuals reported noticing a loss of effectiveness and an increase in side effects after the medication's formulation was changed in 2003. One of the differences (but not the only difference) between the "old" and "new" versions of Nardil was that the "old" version was enteric coating. In addition to the fact that some individuals reported noticing a difference in the way that their Nardil worked after the 2003 formulation change, I and one other Psycho-Babble member have reported noticing an increase in Nardil's effectiveness after switching from taking the film-coated tablets to taking a version of Nardil that involved putting the contents of the tablets into enteric capsules. The other Psycho-Babble member and I are obviously just two individuals, and we haven't made the claim that everybody will be able to replicate the results that we noticed, but we did notice a difference between taking film-coated Nardil tablets and putting the contents of the tablets into enteric capsules.
Tomatheus
Posted by Tomatheus on March 24, 2013, at 18:48:11
In reply to Re: Buy enteric capsules for nardil » jono_in_adelaide, posted by Tomatheus on March 24, 2013, at 18:44:16
I wrote: "One of the differences (but not the only difference) between the "old" and "new" versions of Nardil was that the "old" version was enteric coating."
I meant to write: "One of the differences (but not the only difference) between the "old" and "new" versions of Nardil was that the "old" version had an enteric coating."
Tomatheus
Posted by jono_in_adelaide on March 25, 2013, at 1:37:52
In reply to Re: Buy enteric capsules for nardil » jono_in_adelaide, posted by Tomatheus on March 24, 2013, at 18:44:16
Nardil was sugar coated, not enteric coated, until the formulation change
Source: William R Warner data sheet for Nardil, dated 1986
Posted by Tomatheus on March 25, 2013, at 13:11:24
In reply to Re: Buy enteric capsules for nardil, posted by jono_in_adelaide on March 25, 2013, at 1:37:52
> Nardil was sugar coated, not enteric coated, until the formulation change
>
> Source: William R Warner data sheet for Nardil, dated 1986Did the fact sheet say that Nardil wasn't enteric coated, or did you make that part up?
The FDA (2002) stated this in a review document pertaining to the formulation change: "The current tablets are sugar coated. The tablet core is sealed with a coat of pharmaceutical glaze (shellac) prior to applying the sugar coating."
As I mentioned in the post that I linked to earlier, pharmaceutical glaze, or shellac, is an enteric coating material. It is water-insoluble at low pH levels and water-soluble at high pH levels (Pearnchob et al., 2004)
Tomatheus
==
REFERENCE
Pearnchob, N., Dashevsky, A., & Bodmeier, R. (2004). Improvement in the disintegration of shellac-coated soft gelatin capsules in simulated intestinal fluid. Journal of Controlled Release, 94, 313-321. Abstract: http://www.ncbi.nlm.nih.gov/pubmed/14744483
U.S. Food and Drug Administration. (2002). Office of Clinical Pharmacology and Biopharmaceutics review (NDA 11-909/SCM-032). City of publication not available: Author.
This is the end of the thread.
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