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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 15 of 15. This is the beginning of the thread.
Posted by poser938 on March 9, 2012, at 0:20:27
finally made one today. well actually, my 1st appointment is to see the nurse and i guess have her diagnose me. they said on the phone the 1st appointment will be 2 to 3 hours. thats much longer than the last time i was diagnosed. and i will get to talk with the psychiatrist for just a bit, but it wont be an actual appointment with him, i will have to make a second appointment with him. and it is $200 for the 1st visits and then 130 for each visit after that. i dont get why some psychiatrists charge only $45 and then some charge double or triple that, hopefully it means this will be a knowledgeable psychiatrist and not a tool like the others i have seen. and i cannot wait until i get some help... i am feeling pitiful.
i saw on clinicaltrials.gov that they are testing ketamine for use in the ER for people who come that are suicidal. i wish they already had it approved.. i cant stand waiting.
Posted by Phillipa on March 9, 2012, at 10:48:44
In reply to i have a appt for a doc that prescribes Ketamine, posted by poser938 on March 9, 2012, at 0:20:27
Good luck hope it goes well for you and please post results of appointment. Phillipa
Posted by novelagent on March 11, 2012, at 13:31:09
In reply to i have a appt for a doc that prescribes Ketamine, posted by poser938 on March 9, 2012, at 0:20:27
ketamine is like GHB. It will make your incredibly dysphoric at low doses, dehabilitatingly euphoric at high doses, and you will vomit in your sleep and die from the vomit choking you.
so there's that, but hope it goes well.
why stop at ketamine? heard heroin is great. If you'regoing todie from vomitting in your sleep, I'd stick with cheap old heroin-- no doc to pay off. And having paid $300 for docs to get GHB prescribed to ruin my life, I can explain to you why doctors cost more-- they prescribe more. They're drug dealers at a certain point. And I'm not exactly a Scientologist...
take EmSam and a hefty dose of DLPA-- worked for me. I got undepressed from a year and a half of chronic depression within the same day-- teacher even remarked I was smiling on that day, without Me realizing it at first... 2 weeks later, I realized at some point I hadn't craved sleep in the prior 2 weeks, strangely out of pace at the time at that point in my life.
you won't regret it.
> finally made one today. well actually, my 1st appointment is to see the nurse and i guess have her diagnose me. they said on the phone the 1st appointment will be 2 to 3 hours. thats much longer than the last time i was diagnosed. and i will get to talk with the psychiatrist for just a bit, but it wont be an actual appointment with him, i will have to make a second appointment with him. and it is $200 for the 1st visits and then 130 for each visit after that. i dont get why some psychiatrists charge only $45 and then some charge double or triple that, hopefully it means this will be a knowledgeable psychiatrist and not a tool like the others i have seen. and i cannot wait until i get some help... i am feeling pitiful.
>
> i saw on clinicaltrials.gov that they are testing ketamine for use in the ER for people who come that are suicidal. i wish they already had it approved.. i cant stand waiting.
Posted by poser938 on March 12, 2012, at 0:59:35
In reply to Re: i have a appt for a doc that prescribes Ketamine, posted by novelagent on March 11, 2012, at 13:31:09
haha well i do agree with you, psychiatrists are just drug dealers with a degree, especially many of the ones i've seen. but, i do need a psychiatrist that is more willing to work with me. when i 1st started seeing a psychiatrist in 2005 he put me on a few meds, one of them was adderall, and it was freaking awesome for about a month. and i felt good about taking the FDA approved meds the doc prescribed because well, they were FDA approved. i figured they could no permanant harm, especially if i took them as prescribed by the doctor. i was wrong. ever since then i have been trying to get my normal functioning brain back because of permanent effects meds have had on me.
i have Dopamine Agonist Withdrawal Syndrome (DAWS)from taking Mirapex in 2009, along with some other side effects from meds like Effexor.
i'm hoping ketamine will help set my brain back to nromal.
Posted by SLS on March 12, 2012, at 7:00:35
In reply to Re: i have a appt for a doc that prescribes Ketamine, posted by poser938 on March 12, 2012, at 0:59:35
Hi.
> i have Dopamine Agonist Withdrawal Syndrome (DAWS)from taking Mirapex in 2009,
Would you describe the features of this syndrome? I have never heard of it.
> i'm hoping ketamine will help set my brain back to nromal.
Is this an intuitive concept of yours, or is there evidence or opinion that supports it?
I really hope ketamine does for you what you need it to.
Good luck.
- Scott
Posted by poser938 on March 12, 2012, at 8:12:17
In reply to Re: i have a appt for a doc that prescribes Ketamine » poser938, posted by SLS on March 12, 2012, at 7:00:35
well,i believe there are a few different symptoms of it that different people get. and i have read many aritcles talking about how those with parkinsons disease that are taking dopamine agonists like mirapex or requip can end up with a syndrome.
http://www.pdonlineresearch.org/responses/24952/300/authors-describe-dopamine-agonist-withdrawal-syndrome-daws
it talks about the syndrome in this article. with me, i had been taking miarpex for about a month and it was having no effect on my mood, but i did become more sensitive to sexual stimulation, and that was about all it did. but after a month i took my regular dose and then about an hour later my ability to feel pleasure became MUCH worse than it already was. i decided i wasnt going to take another dose and i ended up trying ritalin a few weeks later since i seemed to not be getting better from what mirapex did. i took 1 dose of the ritalin and felt more able to feel pleasure for a couple of hours, but once it wore off my ability to feel pleasure was lessened even more.i believe it was basically too much unnatural stimulation in the dopamine centers in my brain from dopamine meds, causing my brain to halt dopamine production. i have tried a couple of antipsychotics, including amisulpride, hoping they would end up turning the dopamine back on, but they did nothing. no effect on my mood, no emotional numbing while it was in my system or anything.
like i mentioned before, cyproheptadine is the only thing that has helped any. i think it helped by 5ht2c antagonism. i read when this receptor is blocked off, your brains natural reaction to pleasurable things increases and more dopamine is released. but i would get tolerant to a single dose after just a few days and raised the dose over a 6 month period i got to a very high dose... that was like a year ago and im still tolerant to it.
now with ketamine, to be honest, i dont understand much about it. i have read some articles on how it increases dopamine release in the brain and im hoping it does it in the right way to help me out, rather that how something like ritalin does it. and i also talked to someone on socialanxietysupport.com who has been going through the same thing i have been ever since he took mirapex. he said he took ketamine and it helped him quite a bit. i just like what ive read others say about it, too. they mention how their brain feels like it has been reset and how it feels like it is just functioning better and clearer.
i do worry that ketamine also works as a dopamine agonist in a way like mirapex, and im going to talk to the psychiatrist about whether i should try an antipsychotic while the ketamine is in my system. i just cant tolerate certain kinds of dopamine stimulation.
Posted by poser938 on March 12, 2012, at 10:16:44
In reply to Re: i have a appt for a doc that prescribes Ketamine, posted by poser938 on March 12, 2012, at 8:12:17
haha wow i wrote alot
Posted by SLS on March 12, 2012, at 19:16:32
In reply to Re: i have a appt for a doc that prescribes Ketamine, posted by poser938 on March 12, 2012, at 10:16:44
> haha wow i wrote alot
You sure did!
Good stuff, though.
- Scott
Posted by SLS on March 12, 2012, at 19:27:56
In reply to Re: i have a appt for a doc that prescribes Ketamine, posted by poser938 on March 12, 2012, at 8:12:17
Hi.
Thanks for the information and personal descriptions.
Amantadine and ketamine do not interact directly with dopamine receptors in the way that Mirapex does. I guess you knew that already.
Your choice of amisulpride would appear to be a logical one. I'm sorry it didn't work.
Have you tried Abilify? Abilify acts like a dynamically balanced combination of antipsychotic and dopamine agonist. It is called a "partial agonist", and seems to act as a buffer between overstimulation and understimulation. Another drug called cariprazine will probably come to market. It, too, is a dopamine D2/D3 receptor partial agonist.
The brain "reset" conceptualization of the action of ketamine is attractive.
- Scott
Posted by Avenarius on March 12, 2012, at 20:47:23
In reply to i have a appt for a doc that prescribes Ketamine, posted by poser938 on March 9, 2012, at 0:20:27
How is the ketamine prescribed? Oral, sublingual, intranasal, or intranasal?
What part of the country/world do you live in?
> finally made one today. well actually, my 1st appointment is to see the nurse and i guess have her diagnose me. they said on the phone the 1st appointment will be 2 to 3 hours. thats much longer than the last time i was diagnosed. and i will get to talk with the psychiatrist for just a bit, but it wont be an actual appointment with him, i will have to make a second appointment with him. and it is $200 for the 1st visits and then 130 for each visit after that. i dont get why some psychiatrists charge only $45 and then some charge double or triple that, hopefully it means this will be a knowledgeable psychiatrist and not a tool like the others i have seen. and i cannot wait until i get some help... i am feeling pitiful.
>
> i saw on clinicaltrials.gov that they are testing ketamine for use in the ER for people who come that are suicidal. i wish they already had it approved.. i cant stand waiting.
Posted by poser938 on March 12, 2012, at 21:04:01
In reply to Re: i have a appt for a doc that prescribes Ketamine » poser938, posted by SLS on March 12, 2012, at 19:27:56
i think if i understand partial agonism correctly, i dont think something like abilify would help.
i could be wrong, but i dont think any of the dopamine agonists will make me better able to feel emotional pleasure such as when listening to music. considering this i dont think it's worth trying. and if it does cause even a tiny bit of unnatural stimulation, i might be more sensitive sexually for a bit, but then be even worse afterwards.oh and thanks for reminding me about amantadine, i ussed to read about it quite a bit but i had just forgotten about it. it might be good for me, but according to wikipedia it is a DRI, this part of it could be bad for me. i forgot to mention that i had tried an indirect approach at raising dopamine after the mirapex messed me up, with tianeptine and after about 10 days on it my ability to respond to pleasurable thnigs had become even worse.
i think if i had taken the tianeptine 1st before ever trying mirapex, i would have had a better experience with it. but im going to keep amantadine in my list of things to try.
Posted by poser938 on March 12, 2012, at 21:50:59
In reply to Re: i have a appt for a doc that prescribes Ketamine, posted by Avenarius on March 12, 2012, at 20:47:23
im actually not sure how it is usually prescribed. i've read about some people getting at a compounding pharmacy in pill form and i've read about the doctor injecting it at the office.
Posted by SLS on March 13, 2012, at 0:07:00
In reply to Re: i have a appt for a doc that prescribes Ketamine, posted by poser938 on March 12, 2012, at 21:04:01
Hi.
> oh and thanks for reminding me about amantadine, i ussed to read about it quite a bit but i had just forgotten about it. it might be good for me, but according to wikipedia it is a DRI, this part of it could be bad for me.
Several sources I have seen list amantadine as being a releaser of DA rather than a reuptake inhibitor. This might make it similar to the now discontinued pemoline, which I found to be considerably "smoother" than methylphenidate (Ritalin).
What happens when you take amphetamine? I find Dexedrine and Adderal to be "smoother" than methylphenidate. For me, methylphenidate causes me to feel agitated and irritable without improving depression.
- Scott
Posted by poser938 on March 13, 2012, at 7:33:17
In reply to Re: i have a appt for a doc that prescribes Ketamine » poser938, posted by SLS on March 13, 2012, at 0:07:00
im just doing some quick reading from wikipedia, but i guess i misread about amantadine earlier. so it's just a dopamine releaser by stimulating nerve endings? idk.. im not too sure how well that would cooperate with my brain. but im reading about pemoline and it is saying on wikipedia that it is a DRI. i just have to be careful because if one of these meds messes up my dopamine system even more, i will be stuck like that, at least until i can find another med to fix it.
adderall was one of the 1st meds i had taken and it did basically the same thing that mirapex ended up doing after a month. with adderall though, the cyproheptadine had fixed the problem right up after taking it a few weeks, making mybrain tolerant of dopamine increasing meds again.
Posted by novelagent on March 22, 2012, at 11:19:28
In reply to Re: i have a appt for a doc that prescribes Ketamine, posted by poser938 on March 12, 2012, at 8:12:17
Poser,
I had severe depression that I tried everything for a year and a half, and nothing worked. Then I tried selegiline, 5mg, along with DLPA. Within the same day of taking it, I felt more alive than ever (which I would dismiss as a placebo effect, if it weren't for the specific combo being known for causing this short-circuiting). It's now sold in the U.S. as a patch, Emsam.
I had anhedonia like you have, although yours appears to be absent from depression... you might want to try it. I noticed two weeks into things that I hadn't craved sleep for the prior two weeks, and I didn't want to nap like I was doing for all the time back when I was depressed.
I also mention this a lot, but I'm interested in the success of CDP Choline (citicholine) in the treatment of cocaine addicts. That's because cocaine addicts have, like many who -aren't- cocaine addicts (such as yourself) share a common problem: dopamine circuitry damage.
If one treats their cocaine addiction, at least in this case, it's likely due to treating the underlying problem of damaged dopamine receptors. In the study, 1g taken twice daily was tried for a couple of months, although it may take longer for some to experience results.
note: I'm not comparing you to a cocaine addict, and I use loose parallels for creative reasons =)
anyway, I'm interested in trying mirapex for a problem I had-- I'm a guy, and I've never had an orgasm through intercourse before. Based on your experience, do you think it might help with that?
---
> well,i believe there are a few different symptoms of it that different people get. and i have read many aritcles talking about how those with parkinsons disease that are taking dopamine agonists like mirapex or requip can end up with a syndrome.
>
> http://www.pdonlineresearch.org/responses/24952/300/authors-describe-dopamine-agonist-withdrawal-syndrome-daws
> it talks about the syndrome in this article. with me, i had been taking miarpex for about a month and it was having no effect on my mood, but i did become more sensitive to sexual stimulation, and that was about all it did. but after a month i took my regular dose and then about an hour later my ability to feel pleasure became MUCH worse than it already was. i decided i wasnt going to take another dose and i ended up trying ritalin a few weeks later since i seemed to not be getting better from what mirapex did. i took 1 dose of the ritalin and felt more able to feel pleasure for a couple of hours, but once it wore off my ability to feel pleasure was lessened even more.
>
> i believe it was basically too much unnatural stimulation in the dopamine centers in my brain from dopamine meds, causing my brain to halt dopamine production. i have tried a couple of antipsychotics, including amisulpride, hoping they would end up turning the dopamine back on, but they did nothing. no effect on my mood, no emotional numbing while it was in my system or anything.
>
> like i mentioned before, cyproheptadine is the only thing that has helped any. i think it helped by 5ht2c antagonism. i read when this receptor is blocked off, your brains natural reaction to pleasurable things increases and more dopamine is released. but i would get tolerant to a single dose after just a few days and raised the dose over a 6 month period i got to a very high dose... that was like a year ago and im still tolerant to it.
>
> now with ketamine, to be honest, i dont understand much about it. i have read some articles on how it increases dopamine release in the brain and im hoping it does it in the right way to help me out, rather that how something like ritalin does it. and i also talked to someone on socialanxietysupport.com who has been going through the same thing i have been ever since he took mirapex. he said he took ketamine and it helped him quite a bit. i just like what ive read others say about it, too. they mention how their brain feels like it has been reset and how it feels like it is just functioning better and clearer.
>
> i do worry that ketamine also works as a dopamine agonist in a way like mirapex, and im going to talk to the psychiatrist about whether i should try an antipsychotic while the ketamine is in my system. i just cant tolerate certain kinds of dopamine stimulation.
This is the end of the thread.
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