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Dr. Bob is Robert Hsiung, MD,
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Posted by stargazer2 on September 23, 2011, at 18:48:21
In reply to Re: ...taking Marplan? (My AD-history-in-a-box.) » stargazer2, posted by zonked on September 23, 2011, at 18:15:32
Thank you...without getting relief life is not worth living anymore...When I started this battle in 1987 I was under the impression that my depression was treatable. I became aware of the resistent nature of my depression and began to live a life of utter hopelessness. No matter what I tried, remission was elusive.
The only other combination that did something for a few years was Celexa, Wellbutrin and adderall.
I also took Emsam with little effect.
I also have been on Lamictal, Zyprexa, Seroquel, Risperdal and scads of AD's too numerous to mention.
If the Marplan didn't work, we were going to try Amino Acids, which for a psychiatrist is unheard of.
I also toyed with the idea of Transmagnetic Stimulation or Vagus Nerve Stim but as with ECT, I'm terrified by those treatments.
I just want "normal" depression that responds to medications like most people's do. I don't know why my life has been so difficult, it seems like I was chosen to suffer and not be given a fair chance at life. I always wondered why.
Maybe this is my time to shine.
SG
Posted by jaybtv2 on September 26, 2011, at 18:54:28
In reply to Re: Is anyone currently taking Marplan?, posted by jch on September 19, 2011, at 19:05:53
I don't frequent this forum too much anymore but just wanted to say I'm still taking Marplan (30mg) and the last year and a half has been great.
Some of the success has to do with positive life changes like a move and quitting drinking completely but I know Marplan has done a lot to keep me from dropping into depression.
Posted by stargazer2 on September 26, 2011, at 19:18:57
In reply to Re: Is anyone currently taking Marplan?, posted by jaybtv2 on September 26, 2011, at 18:54:28
Jay, that's great.
I have had a relapse in the last day or so with feeling suicidal on 50 mg Marplan, so I'm going back to 40 to see if perhaps 50 was too much. Also I;m increasing the seroquelXR from 50 to 150.
My doc is very worried about some of the things I said to him today so he wants to see me tomorrow. He mentioned putting me into the hospital but that's not going to happen.
All of these meds are so tempermental. I just hope I can get back to a baseline and stabalize as nothing else has worked so well that I'm afraid to have this fail me.
SG
Posted by Phillipa on September 26, 2011, at 21:19:29
In reply to Re: Is anyone currently taking Marplan?, posted by stargazer2 on September 26, 2011, at 19:18:57
SG hang in there it will work. I know it will. Love Phillipa
Posted by shot_away on October 4, 2011, at 11:00:46
In reply to Re: Is anyone currently taking Marplan?, posted by jch on September 19, 2011, at 19:05:53
I take Marplan! Thinking of changing tho. Since I've been on Abilify (which has helped) my BP has plumetted so much I'm constantly getting dizzy spells and collapsing. Some siezures too. Its not all down to Marplan but I do take 90mg of it and it produced hypotension by itself.
Next step is to come off Marplan and also drop Valdoxan in exchange for Parnate which I've never tried but have big hopes for. If that fails its back to Nardil- its been a while so I'd be hoping for that Nardil 'magic' again! Who knows...
Yep, Marplan is a hit-or-miss/come-and-go med alright!!! More of a background effect IMHO.
Posted by Lamdage22 on October 5, 2011, at 4:22:29
In reply to Re: Is anyone currently taking Marplan?, posted by shot_away on October 4, 2011, at 11:00:46
Im contemplating to do a 1 month Marplan trial. Currently on Nardil. Nardil works but not anything like it once used to
Posted by Chairman_MAO on October 5, 2011, at 22:58:18
In reply to Re: Is anyone currently taking Marplan?, posted by Lamdage22 on October 5, 2011, at 4:22:29
I'm hoping to get on Marplan soon; the weight gain from Nardil was too much.
Right now my pdoc does not seem too keen on adding an MAOI to a stimulant instead of vice-versa, but he said he is not ruling it out yet. I tried to take Viibryd for 10 days, I felt so horrible (anxious, GI upset, just utterly rotten) I had to quit it. I hope he doesn't take that as a sign of "noncompliance", but man that was awful. All you guys who feel good on SSRIs have got it made! ;-)
Posted by Lamdage22 on October 6, 2011, at 11:29:01
In reply to Re: Is anyone currently taking Marplan? » Lamdage22, posted by Chairman_MAO on October 5, 2011, at 22:58:18
So i hear occasionally that Marplan isn't nearly as bad on weight gain as Nardil.. Is that true??
I've been gaining like mad, too. From 90mg nardil.The changes i have done is i started dieting and started severe exercise.. (as much as my body is ready to take at this point)
My diet secret is a no-carb policy, At least 2g per kg Bodyweight Protein and moderate intake of healthy fats.
Really since I've kicked the carbs i can control my hunger awesomely. The second i start eating bread again theres an urge to binge-eat coming on.
I have lost good 8 pounds.22 to go.. cheer for me:)
No carb doesn't mean no carbs at all, but trying to stay as low as possible. It means no eating bread, no noodles, no rice and no all the other high carb foods.
Its good old bodybuilding knowledge;) They know how to diet. I will soon make a thread with my diet strategy in detail, as it works great and may for others, too.
Greetings, Ld
> I'm hoping to get on Marplan soon; the weight gain from Nardil was too much.
>
> Right now my pdoc does not seem too keen on adding an MAOI to a stimulant instead of vice-versa, but he said he is not ruling it out yet. I tried to take Viibryd for 10 days, I felt so horrible (anxious, GI upset, just utterly rotten) I had to quit it. I hope he doesn't take that as a sign of "noncompliance", but man that was awful. All you guys who feel good on SSRIs have got it made! ;-)
Posted by Chairman_MAO on October 6, 2011, at 12:07:39
In reply to Weight gain. Successful diet despite nardil!, posted by Lamdage22 on October 6, 2011, at 11:29:01
Marplan is not nearly as bad, I don't think.
If you stick to your diet, the weight gain should be minimal. That is in line with my [layman's] understanding of the Nardil weight problem. It has to do primarily with phenelzine and/or its active metabolite (PEH) on http://en.wikipedia.org/wiki/Gluconeogenesis
Posted by Lamdage22 on October 6, 2011, at 12:20:41
In reply to Re: Weight gain. Successful diet despite nardil! » Lamdage22, posted by Chairman_MAO on October 6, 2011, at 12:07:39
> Marplan is not nearly as bad, I don't think.
>
> If you stick to your diet, the weight gain should be minimal. That is in line with my [layman's] understanding of the Nardil weight problem.No, there is no weight gain. With me there is weight loss.
With meds that "cause weight gain", never forget that we breathe air. Less calories than your body needs to maintain weight equals weight loss, Nardil or not, you LOSE weight in
this calorie deficient cenario.I will give marplan a one month trial even though its gonna cost me like 500 dollars. No idea why as they sell nardil at a great price.
Anyway drop the carbs, raise protein: you gonna have an easier time with not overeating, or eating less kcal than the body needs.
Lamdage
>
Posted by Chairman_MAO on October 6, 2011, at 13:50:53
In reply to Re: Weight gain. Successful diet despite nardil!, posted by Lamdage22 on October 6, 2011, at 12:20:41
"With meds that "cause weight gain", never forget that we breathe air. Less calories than your body needs to maintain weight equals weight loss, Nardil or not, you LOSE weight in
this calorie deficient cenario."Yeah, I get that. You will lose weight. However, at some point you will stop losing weight and will be at a point where you wish to maintain that weight. All other things being equal, odds are that most people end up somewhat heavier on Nardil.
"Anyway drop the carbs, raise protein: you gonna have an easier time with not overeating, or eating less kcal than the body needs."
Yes, you are correct. If you're able to stick to an ultra-low-carb diet on Nardil, more power to you. In order for me not to have _intense_ carbohydrate cravings on that stuff, I'd have to basically eliminate carbohydrates. And even in that scenario, I imagine that I'd still weigh a little bit more, because one cannot completely eliminate carbohydrates.
http://www.ncbi.nlm.nih.gov/pubmed/3791153?dopt=Citation
"Hydrazine sulfate was evaluated using 24-hour dietary recalls and body weight determinations before and after 30 days of either placebo or hydrazine (60 mg, 3 times/d) oral administration in 101 heavily pretreated cancer patients with weight loss. After 1 month, 83% of hydrazine and only 53% of placebo patients completing repeat evaluation maintained or increased their weight (P less than 0.05). In addition, appetite improvement was more frequent in the hydrazine group (63% versus 25%, P less than 0.05). Although caloric intake was only slightly greater in hydrazine-treated patients, an increased caloric intake was more commonly associated with weight gain in patients receiving hydrazine compared with those receiving placebo (81% versus 53%, respectively). Hydrazine toxicity was mild, with 71% of patients reporting no toxic effects. Hydrazine sulfate circulatory levels were obtained from a subset of 14 patients who completed 30 days of treatment, with a single sample obtained in the morning at least 9 hours after the last dose. Mean maintenance hydrazine sulfate levels, determined using a spectrofluorometric assay, ranged from 0 to 89 ng/ml (mean 45 +/- 16 ng/ml). These data, which demonstrate an association between 1 month of hydrazine sulfate administration and body weight maintenance in patients with cancer, suggest future clinical trials of hydrazine sulfate are indicated to definitively assess its long-term impact on important clinical outcome parameters in defined cancer populations."
And this is in a scenario where people are _trying desperately_ to gain weight.
Posted by Lamdage22 on October 7, 2011, at 7:38:48
In reply to Re: Weight gain. Successful diet despite nardil! » Lamdage22, posted by Chairman_MAO on October 6, 2011, at 13:50:53
> Yes, you are correct. If you're able to stick to an ultra-low-carb diet on Nardil, more power to you. In order for me not to have _intense_ carbohydrate cravings on that stuff, I'd have to basically eliminate carbohydrates. And even in that scenario, I imagine that I'd still weigh a little bit more, because one cannot completely eliminate carbohydrates.
It does not cause me all to much effort honestly. My life is funny.. when I'm down i can't bring up discipline/drive for anything.
When I'm up it seems to go without all too much effort. Even with some ease. At some point it makes "click" i pull through with everything i have and i get into something like auto-mode.
I feel relief and thats probably also a reason i have an easy time with losing weight. Weight gain is also atypical depression, which nardil is prescribed for.My med/supplement regimen seems to work and I'm soon starting therapy again. I told my regular hooker that i do like her very much (i do) but i won't be her customer anymore. She told me stuff like "i like you" "i love you" and "marry me" over and over again and we had good connection. Anyway: Gave her my number and told her it'd be up to her if we see each other again or not. It was a courageous step for me.
Right now i feel a little bit like this: http://www.youtube.com/watch?v=dkgbThFqDdQ i REALLY do:)..Greetings,
..Lamdage..Ps. Like i said i will post my diet strategy in detail as soon as i find time. Its golden for me :)
Posted by stargazer2 on October 7, 2011, at 9:26:47
In reply to Re: Weight gain. Successful diet despite nardil!, posted by Lamdage22 on October 7, 2011, at 7:38:48
The divorce diet works wonders, lost 40 pounds while on Nardil. Gaining it back on Marplan but not at a baseline yet.
Stargazer
Posted by Lamdage22 on October 7, 2011, at 10:45:27
In reply to Divorce diet on NArdil, posted by stargazer2 on October 7, 2011, at 9:26:47
Sounds like it was more for personal reasons than the meds?
Ld
Posted by shot_away on October 7, 2011, at 16:34:00
In reply to Weight gain. Successful diet despite nardil!, posted by Lamdage22 on October 6, 2011, at 11:29:01
> So i hear occasionally that Marplan isn't nearly as bad on weight gain as Nardil.. Is that true??
Its true! But everything on Marplan seems less compared to Nardil. Side effects but efficiacy too. Its like a background drug- one to augment for sure. Maybe an excellent med for depression alone, but the slightest accompanying anxiety and you'll need something else coz Marplan is too activating in this case. Major depressives may also find it fairly weak. Remember- 10mg for every 15mg of Nardil is the equivalent. I take 90mg Marplan and still need a second AD + Abilify. And still 4-5mg Klonopin for the SA. Lets face it, Nardil can do it all when it works. Aww, its getting more tempting that Nardil!!
Posted by shot_away on October 7, 2011, at 16:42:30
In reply to Re: Weight gain. Successful diet despite nardil! » Lamdage22, posted by shot_away on October 7, 2011, at 16:34:00
I will add, that the diet on Marplan is much less restricted than the other 2 non-selective MAOIs. Whatever the doc says! I've eten most things, apart from very fermented foods and always been fine. I can still eat cheesy piza. Wouldn't dare on Nardil.
Weight gane is very unlikely too unless u have a particularly carby tongue! In Marplan's case you are what you eat.
Posted by shot_away on October 7, 2011, at 17:35:10
In reply to Re: Weight gain. Successful diet despite nardil!, posted by Lamdage22 on October 6, 2011, at 12:20:41
Lamdage! Any chance you can turn on your babblemail briefly for a quick private exchange of words?
Posted by Lamdage22 on October 7, 2011, at 20:24:15
In reply to Lamdage22! » Lamdage22, posted by shot_away on October 7, 2011, at 17:35:10
> Lamdage! Any chance you can turn on your babblemail briefly for a quick private exchange of words?
Sure.. Consider it done. 90mgs of marplan is not very much, i hear the max recommendet dosage is pussy and undsrestimated.
Posted by shot_away on October 8, 2011, at 7:46:56
In reply to Re: Lamdage22!, posted by Lamdage22 on October 7, 2011, at 20:24:15
> Sure.. Consider it done. 90mgs of marplan is not very much, i hear the max recommendet dosage is pussy and undsrestimated.
Yes but wait till you get to 80mg+ and feel the postural hypotention! Its what im battling with now at 90mg after over 3 years on it! And thats before i added abilify too which has the same effect on me. Ah well...
Posted by Chairman_MAO on October 9, 2011, at 8:30:51
In reply to Re: Lamdage22! » Lamdage22, posted by shot_away on October 8, 2011, at 7:46:56
Re: postural hypotension. There are treatments for it, as you are probably aware. Have you tried any of them?
Posted by shot_away on October 9, 2011, at 10:42:03
In reply to Re: Lamdage22! » shot_away, posted by Chairman_MAO on October 9, 2011, at 8:30:51
> Re: postural hypotension. There are treatments for it, as you are probably aware. Have you tried any of them?
Well actuallly, no I haven't. Not sure what my doc would think but please, i'd like to here the options!
Oh, I did do a trial with table salt (sodium) and it did raise my BP but it was too high whilst sat or laying down so I stopped. BP was perfect whilst standing tho, and getting up was better.
Posted by Chairman_MAO on October 9, 2011, at 10:49:19
In reply to Re: Lamdage22! » Chairman_MAO, posted by shot_away on October 9, 2011, at 10:42:03
This list seems pretty good: http://www.dizziness-and-balance.com/disorders/medical/orthostatic.html
Posted by shot_away on October 9, 2011, at 10:50:08
In reply to Re: Lamdage22!, posted by Lamdage22 on October 7, 2011, at 20:24:15
>90mgs of marplan is not very much, i hear the max recommendet dosage is pussy and undsrestimated.
>
>
>
>Where did you hear this? I'm interested. Got any links?? What dosage strategy are you planning on urself?
Posted by shot_away on October 9, 2011, at 10:54:02
In reply to Re: Lamdage22! » shot_away, posted by Chairman_MAO on October 9, 2011, at 10:49:19
Posted by Lamdage22 on October 10, 2011, at 5:12:29
In reply to Re: Lamdage22! » Lamdage22, posted by shot_away on October 9, 2011, at 10:50:08
> >90mgs of marplan is not very much, i hear the max recommendet dosage is pussy and undsrestimated.
> >
> >
> >
> >
>
> Where did you hear this? I'm interested. Got any links?? What dosage strategy are you planning on urself?Oh i don't remember.. i just scan through very much information so i have an inkling of whats going on with what else is out there.
Im not planning the Marplan yet, got other stuff to take care of.
I think to have heard 120mgs but don't count on it, this is something i believe to have heard somewhere i don't remember.You can just google marplan with words like high dosage, 110mg etc etc.
It may be wise to label my "slight inklings" as such to prevent people from doing things based solely on my posts. Im sure if you search you will find something though. It might very well have been on anxiety support.
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