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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 4 of 4. This is the beginning of the thread.
Posted by Laney on July 24, 2011, at 13:54:44
I found this while looking up information on desiprimine. I am hypothyroid meaning I will need to go on thyroid medication at my next doctor's appointment on August 5th. Can anyone explain to me what this means regarding thyroid?
Warnings
Extreme caution should be used when desipramine is given in the following situations: (1) In patients with cardiovascular disease, because of the possibility of conduction defects, arrhythmias, tachycardias, strokes and acute myocardial infarction. (2) In patients with a history of urinary retention or glaucoma, because of the anticholinergic properties of the drug. (3) In patients with thyroid disease or those taking thyroid medication, because of the possibility of cardiovascular toxicity, including arrhythmias. (4) In patients with a history of seizure disorder, because this drug has been shown to lower the seizure threshold.
Posted by Phillipa on July 25, 2011, at 0:15:43
In reply to Desiprimine and thyroid, posted by Laney on July 24, 2011, at 13:54:44
Laney according to what you posted can cause cardiac problems if have thyroid disorder which is serious. My thyroid went at menopausal age. Hasimotos is the most common. Might be causing the depression/anxiety also as was mine more than I knew at the time. Seriously glad you found out now. Love Phillipa
Posted by desolationrower on July 30, 2011, at 21:51:20
In reply to Re: Desiprimine and thyroid » Laney, posted by Phillipa on July 25, 2011, at 0:15:43
I don't know how thyroid meds would cause arrythmia, but if you are stable & heart is ok, i don't think this is a big risk. i think the heart problems usually occur in ODs. that was part of the reason ssris became popular, you don't kill yourself if you take a month's worth at one time.
-d/r
Posted by SLS on July 31, 2011, at 6:09:21
In reply to Desiprimine and thyroid, posted by Laney on July 24, 2011, at 13:54:44
> I found this while looking up information on desiprimine. I am hypothyroid meaning I will need to go on thyroid medication at my next doctor's appointment on August 5th. Can anyone explain to me what this means regarding thyroid?
>
> Warnings
>
> Extreme caution should be used when desipramine is given in the following situations: (1) In patients with cardiovascular disease, because of the possibility of conduction defects, arrhythmias, tachycardias, strokes and acute myocardial infarction. (2) In patients with a history of urinary retention or glaucoma, because of the anticholinergic properties of the drug. (3) In patients with thyroid disease or those taking thyroid medication, because of the possibility of cardiovascular toxicity, including arrhythmias. (4) In patients with a history of seizure disorder, because this drug has been shown to lower the seizure threshold.Maybe excise the word "Extreme".
Taking precautions is justifiable with desipramine. I never had a problem combining desipramine with Parnate or Nardil. Such combinations are absolutely contraindicated according to the majority of articles dealing with this issue. I have also added T4 to these two drugs. One thing not mentioned in your quote is the rate of occurrence of untoward side effects. How common are these events when desipramine is taken at therapeutic dosages?
For some clients, doctors will take a baseline EKG so it can be compared to EKGs taken later during desipramine therapy.
d/r makes a great point regarding the relative safety of antidepressants in overdose. Desipramine certainly produces cardiotoxicity and even death in these circumstances.
- Scott
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