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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 7 of 7. This is the beginning of the thread.
Posted by SheilaC on July 27, 2011, at 11:14:19
I have found Geodon similar to Wellbutrin in the sense that at lower doses both meds make me manic.
At a high dose of Wellubtrin I slept all the time.
I've been told for stabilizing effects you have to take higher doses of Geodon - not lower doses.
What brain chemicals does Geodon effect at lower and higher levels to make this so? Anyone know?
Posted by Christ_empowered on July 27, 2011, at 15:15:27
In reply to Neurotransmitters + Geodon?, posted by SheilaC on July 27, 2011, at 11:14:19
Geodon apparently has some built-in reuptake inhibition...serotonin and norepinephrine, I think (not sure though).
I read online that there have been cases reported of Geodon-induced mania, although most of them seem to have happened when Geodon was used with an antidepressant drug to treat depression.
Low dose antipsychotics are sometimes activating. Geodon might be better for you at a higher dose, or maybe you need a different tranquilizer.
Good luck.
Posted by Sheilac on July 27, 2011, at 17:09:11
In reply to Re: Neurotransmitters + Geodon?, posted by Christ_empowered on July 27, 2011, at 15:15:27
So you think the reuptake inhibition of the serotonin and norepinephrine could cause the hypomania and antidepressant effect? Maybe at higher doses that goes away?
When I used to take as little as 50mg of Seroquel at night to sleep I found got an antidepressant effect, but no mania.
My tranquilizer is Klonopin for anxiety.
Posted by sheilac on July 30, 2011, at 7:49:28
In reply to C_E - Neurotransmitters + Geodon?, posted by Sheilac on July 27, 2011, at 17:09:11
After reading on the internet, this makes sense.
I experienced the worst mania from Effexor, which is an SNRI. But, it was also a great antidepressant. Couldn't stay on it due to how nuts it made me.
I guess that's why the Geodon at a higher dose is working for me.
I didn't start to feel better until I took 80mg at night.
I am experimenting now with either 20mg or 40mg in the daytime with Nuvigil or Adderall.
Don't know which is less likely to induce mania - Adderall or Nuvigil.
Posted by desolationrower on July 30, 2011, at 21:24:11
In reply to Thanks, C_E - Neurotransmitters + Geodon?, posted by sheilac on July 30, 2011, at 7:49:28
I haven't seen anything that would explain this effect of geodon. from known bindings, it should be similar to other atypicals
-d/r
Posted by sheilac on July 31, 2011, at 13:56:42
In reply to Re: Thanks, C_E - Neurotransmitters + Geodon?, posted by desolationrower on July 30, 2011, at 21:24:11
desolationrower, are you saying that you don't think Geodon or Abiliy or other anti-psychotics or SNRIs could induce mania?
Something about those meds does induce mania in me - not calm me down. But at the same time they do give me an antidepressant effect - just too much so.
But Geodon at 40mg made me manic and I was a shoppin fool! $$$
Why would Geodon make me so manic then?
Or should I just use Geodon to enhance low dose Lithium?
Posted by desolationrower on July 31, 2011, at 19:29:26
In reply to Re: Thanks, C_E - Neurotransmitters + Geodon?, posted by desolationrower on July 30, 2011, at 21:24:11
well, i meant i don't see why this would be unique to geodon.
I looked again, i think i hadn't reazlized it is actually a full agonist at 5ht1a, and some relevant activity at 5ht1d. the kidb site has been down lately and some of the initial publications were somewhat incorrect i think. i'm not sure that really points to a simple solution, though.
-d/r
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