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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 3 of 3. This is the beginning of the thread.
Posted by desolationrower on July 8, 2011, at 23:28:52
I was thinking maybe ldn, but this study said that was the opposite. [1]
maybe food intake is misplaced DA related hedonism? in which case it is a problem of habits formed in low-reward environment persist into high-reward environment.
i need to learn more abotu the concept of satiation.
1
Selective effects of naltrexone on food pleasantness and intake
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$ 31.50Martin R. YeomansCorresponding Author Contact Information and Richard W. Gray
Laboratory of Experimental Psychology, University of Sussex, Brighton, BNq 9QG, UK
Received 30 August 1995.
Available online 15 February 2003.Abstract
The effects of 50 mg naltrexone on both pleasantness and intake of 10 common food items were investigated using a double-blind placebo-controlled study with 16 male volunteers. Rated food pleasantness was reduced significantly in the naltrexone condition compared with both controls (placebo and baseline). However, pleasantness ratings were not affected uniformly across foods, with sweetened, fatty, and high-protein foods being most affected. Changes in rated unpleasantness generally mirrored those for pleasantness, but evaluations of saltiness and sweetness were unaffected by naltrexone. Although total intake was reduced in the naltrexone condition, this was not significant compared with placebo. However, fat and protein intakes were significantly less following naltrexone. The effect of naltrexone on intake was also food dependent, but in this case intake of sweet foods was spared relative to other food categories. The apparent discrepancy between liking and intake data with sweet foods could be interpreted in terms of the likely influence of normal eating styles on food selection during a buffet-style meal, and may explain some contradictions in previous studies of this kind. The implications for understanding opioid involvement in food acceptability are discussed.
Posted by deepreason on July 15, 2011, at 16:00:23
In reply to nardil or other MAOI carb craving, posted by desolationrower on July 8, 2011, at 23:28:52
If the naltrexone is blocking the dopamine and therefore reducing the carb cravings, is it not effectively just stopping part of the MAOI's benefit? ie. the same effect could be achieved with a reduction in dose.
Posted by desolationrower on July 15, 2011, at 20:33:16
In reply to Re: nardil or other MAOI carb craving, posted by deepreason on July 15, 2011, at 16:00:23
> If the naltrexone is blocking the dopamine and therefore reducing the carb cravings, is it not effectively just stopping part of the MAOI's benefit? ie. the same effect could be achieved with a reduction in dose.
I wouldn't consider increased dopainergic and increased (or not increased) opioidergic to be the same. in the unpredicatbility of the difference might be something useful for some people.
-d/r
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