![[dr. bob]](/dr-bob-sm.gif)
Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 7 of 7. This is the beginning of the thread.
Posted by sleepygirl2 on July 15, 2011, at 17:32:06
I take 50mgs. I swear that if I take it less or not at all I get a bit speedy, overactive. I don't understand. People say it's just acting on histamine. Would a similar thing happen with say benadryl?
Posted by Phillipa on July 15, 2011, at 20:21:52
In reply to Low dose seroquel, curious..., posted by sleepygirl2 on July 15, 2011, at 17:32:06
Don't know sounds like could be paradoxical reaction to seroquel? Phillipa
Posted by desolationrower on July 15, 2011, at 21:40:42
In reply to Low dose seroquel, curious..., posted by sleepygirl2 on July 15, 2011, at 17:32:06
> I take 50mgs. I swear that if I take it less or not at all I get a bit speedy, overactive. I don't understand. People say it's just acting on histamine. Would a similar thing happen with say benadryl?
If you are a kid with ADHD, this is a normal reaction to an antihistamine.
(could be a weird thing with how you metabolize it, the one metabolite has more noradrenergic effects, i know scott knows this)
-d/r
Posted by sleepygirl2 on July 15, 2011, at 22:15:43
In reply to Re: Low dose seroquel, curious..., posted by desolationrower on July 15, 2011, at 21:40:42
> > I take 50mgs. I swear that if I take it less or not at all I get a bit speedy, overactive. I don't understand. People say it's just acting on histamine. Would a similar thing happen with say benadryl?
>
> If you are a kid with ADHD, this is a normal reaction to an antihistamine.
>
> (could be a weird thing with how you metabolize it, the one metabolite has more noradrenergic effects, i know scott knows this)
>
> -d/rI meant that I get speeded up when I don't take it.
What I mean to say...I guess, is that people seem to say that it has no effect on mood stability or possible hypomanic symptoms when at low doses like this, that it only helps with sleep, anxiety.
It does slow me down, in the absence of it I am speeded up, but that could just be my body having gotten used to it.
It's the old is it the absence of the med and rebound effects or the resurgence of some "symptom" question.
sorry I'm confusing, it's just that I'm confused. ;-)
I am super ambivalent about taking this medication.
thanks,
sleepy
Posted by SLS on July 16, 2011, at 5:33:33
In reply to Low dose seroquel, curious..., posted by sleepygirl2 on July 15, 2011, at 17:32:06
> I take 50mgs. I swear that if I take it less or not at all I get a bit speedy, overactive. I don't understand. People say it's just acting on histamine.
What people say this?
These people are wrong.
Although Seroquel (quetiapine), like clozapine (the most powerful antipsychotic), has a low affinity for D2 receptors, the higher dosages used do provide for sufficient receptor occupancy. This is accomplished as the average momentary percentage of D2 occupancy produced by quetiapine and its metabolite, norquetiapine, when used at therapeutic dosages, is comparable to other antipsychotics. This occurs as the quetiapine and norquetiapine molecules hop on and off the D2 receptors at a rate sufficient to allow for a net therapeutic response.
I would use the suggestions of others as a starting point for guiding your own research elsewhere on the Internet. For issues that are important to you, the time invested is well worth it.
------------------------
http://www.ncbi.nlm.nih.gov/pubmed/12444812"Quetiapine dose was correlated with central dopamine D(2) occupancy,"
------------------------
http://en.wikipedia.org/wiki/Quetiapine
"DosageAt very low doses quetiapine acts primarily as a histamine receptor blocker (antihistamine) and α1-adrenergic blocker. When the dose is increased quetiapine activates the adrenergic system and binds strongly to serotonin receptors and autoreceptors. At high doses (over 250 mg) quetiapine starts blocking significant amounts of dopamine receptors"
------------------------
- Scott
Posted by SLS on July 16, 2011, at 5:43:17
In reply to Re: Low dose seroquel, curious... » desolationrower, posted by sleepygirl2 on July 15, 2011, at 22:15:43
Sorry...
I didn't read your post closely enough. I hadn't seen that you were talking only about low dosages of Seroquel.
The literature, as you can see, does support the idea that most of the effect of low dosages of Seroquel is antihistaminic.
I don't know for sure how much antihistaminic activity contributes to the anti-manic or anti-depressant properties. My guess is that you are experiencing a rebound histaminic activation for having discontinued Seroquel. Activation is not mania, although mania can be activating. You would probably feel a "speeded up" and insomniac effect without manic effect when discontinuing chronic low-dose Seroquel.
Essentially, your observations and deductions are accurate.
- Scott
Posted by sleepygirl2 on July 16, 2011, at 9:03:11
In reply to Re: Low dose seroquel, curious... Sorry. » sleepygirl2, posted by SLS on July 16, 2011, at 5:43:17
Thank you for your time in responding to that post.
I keep wondering if it is worth for me to continue this med.
I know that I will have insomnia without it, be speeded up and uncomfortable, but I think that perhaps I can get through that time if it is some sort of rebound thing.
I get itchy too when it's reduced.
The weight gain, independent of how I was eating, was obvious when I started this med. I don't know that there are alternatives for me, something that would blunt things a bit, but I do wonder.
Thanks again,
Sleepy
This is the end of the thread.
Psycho-Babble Medication | Extras | FAQ
Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.org
Script revised: February 4, 2008
URL: http://www.dr-bob.org/cgi-bin/pb/mget.pl
Copyright 2006-17 Robert Hsiung.
Owned and operated by Dr. Bob LLC and not the University of Chicago.