Psycho-Babble Medication Thread 983009

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Re: the only way out » poser938

Posted by SLS on April 18, 2011, at 5:52:41

In reply to Re: the only way out, posted by poser938 on April 18, 2011, at 0:14:18

You are right about cyproheptadine. It is considered an anti-serotonergic that blocks 5-HT2a and 5-HT2b receptors. This in turn increases dopaminergic activity in various regions of the brain, including the prefrontal cortex - an area important for cognition and mood. Interestingly, 5-HT2a receptor binding is increased in suicide victims. This upregulation might indicate a decrease in serotoninergic activity in the PFC. This is in contrast to the mood-lifting properties of antipsychotics that block 5-HT2a receptors.

Linkadge is very capable. He is an amazing resource for information. I'm sure he will correct my errors and expand upon what I have said.

Have you ever tried Remeron?

I'm glad you are now in a more positive and constructive state of mind. This is a heroic effort in view of the frustration and pain you must endure. Keep it up and continue to think creatively.

Suicide is a way out for which there is no way back in.

There is actually a neurobiology for suicidality. Anger and anxiety make it worse. In other words, there is the possibility that you are currently wired biologically to *feel* suicidal. When this is combined with having to manage a depressing situation, things get dangerous. You might need to start looking at this feeling of suicidality to be artificially produced by a dysfunction brain. Self-talk that recognizes these false fellings might help. It has helped me, especially when I have had bad reactions to medications. I avoid making decisions while in this state.

- Scott

> i stopped going to one because he said there was nothinng else he could do.. and my new one prescribed me celexa(ssr) which is the 1st thing thats usually tried im sure you know. its the only ssri i havent taken and the other ones numbed me to different extents. ive tried wellbutrin and it has a different numbing effect on me than SSRI's.
> Well i'll tell you a bit of my psych history.
> in 2005 when i 1st saw a psych he prescribed me cymbalta and adderall. after about a month my tolerance grew to adderall completely to 20mgs XR so i tried taking 2 of them and i still could not feel it one bit. usually people can up their dose and get and effect but i got nothing. i also ended up with anhedonia/extreme anxiety from that combo.. i suffered for a year and then gave and tried effexor and it made me sooooo NUMB! so i tried adderall again and still got no effect from it at all even tho it had been a year.
> a few days later i asked my doc for cyproheptadine to help with effexor side effects. so i took it, slowly increasing the dose week for about a month..and then all the sudden my anhedonia had gone away. i could feel adderall again, and i was much less numb... but still pretty numb.
>
> 2 years went by and then i finally went to a medical doc to see if anything could take away all the numbness and thats when i was given mirapex. after a month and a half i ended up with anhedonia from it. thats when i realized adderall had caused my anhedonia in the past. so i tried cyproheptadine again, it helped quite a bit again, but i ended having to take too high a dose of it this time and had to stop taking it, unfortuanately.. and ive slowly gotten worse since i stopped taking it in december 2010. im going to get some more of the cyproheptadine tuesday to see if my tolerance has gone down to it yet. i storngly believe cyproheptadine affects dopamine receptors by upregulating them/ sensitiziing them in some way. and that increases the release of dopamine. i dont get how, im just positive it does.
>
> sorry if some of this sounds unclear, i can seriously not think straight .

 

Re: the only way out » poser938

Posted by huxley on April 18, 2011, at 6:07:41

In reply to the only way out, posted by poser938 on April 16, 2011, at 11:16:30

poser,

You have come to the wrong place man.

Check out paxilprogress.com

You will find people who have quit SSRIs and suffer for up to 5 years before recovering. They all mention anhedonia and they all recover eventually.

I strongly suggest you go there and check it out before you listen to anyone here. Contrary to popular belief they don't know what they are talking about.

You know what I have found, even the real pschiatirists dont know what they are doing. They are guessing, I have had several admit that.

So why on earth would you listen to a bunch of anonymous people online talking about dopamine receptors.

No one understands how the brain works or how these drugs effect them. All we can do is go of ancedotal evidence and sometimes our own is our best.

Good luck with whatever you do.

 

Re: the only way out » huxley

Posted by SLS on April 18, 2011, at 6:30:55

In reply to Re: the only way out » poser938, posted by huxley on April 18, 2011, at 6:07:41

> poser,
>
> You have come to the wrong place man.

Perhaps.


> Check out paxilprogress.com
>
> You will find people who have quit SSRIs and suffer for up to 5 years before recovering. They all mention anhedonia and they all recover eventually.

Under what circumstances?

> I strongly suggest you go there and check it out before you listen to anyone here. Contrary to popular belief they don't know what they are talking about.

When you have a chance, please tell me where I went wrong. It would be helpful to everyone here if you could. Also, you might want to critique my question regarding Remeron.

Thanks.


- Scott

 

Re: the only way out

Posted by floatingbridge on April 18, 2011, at 11:05:37

In reply to Re: the only way out » poser938, posted by huxley on April 18, 2011, at 6:07:41

> poser,
>
> You have come to the wrong place man.

You're entitled to your opinion. This place is one of many possible sights. That it is a 'wrong' choice sounds like black/white thinking. That usually has the least positive results by closing down
possibilities.

>
> Check out paxilprogress.com

I was just there the other day. I have
been tapering off various medications. Personally speaking, I didn't find the
information there any more compelling or scientifically sound than here. Or any less anonymous.

It's not like anyone (that I'm aware of) is
proselytizing to just go out and start medication. I'm not 'pro'-medication, rather I advocate freedom of choice based on my subjective and anecdotal knowledge of protracted states of mental illness.

>
> You will find people who have quit SSRIs and suffer for up to 5 years before recovering. They all mention anhedonia
and they all recover eventually.

Good. However, they have lived long enough to do so. And being med-
free does sound nice. Again, there is evidence, depending on what study is brought out, that an untreated brain in a severe state of illness has lost some regenerative ability and needs help of some sort.

>
> I strongly suggest you go there and check it out before you listen to anyone here.

Good suggestion. How about 'while also
talking with various folks here.'? This site isn't quite the solid voting block that your statement suggests.

>Contrary to popular belief they don't know what they are talking about.
>

There's a popular belief somewhere?

> You know what I have found, even the real pschiatirists dont know what they
are doing. They are guessing, I have had
several admit that.

Many people have taxed a doctor's knowledge. But I wouldn't take that as a sign to forgo all medication again.

> So why on earth would you listen to a bunch of anonymous people online talking about dopamine receptors.

Or about Paxil withdrawal for that matter. Strange times call for strange
measures. We find ourselves online
largely due to self-advocacy.

> No one understands how the brain works or how these drugs effect them. All we can do is go of ancedotal evidence and sometimes our own is our best.
> Good luck with whatever you do.
>

Yes, good luck to us all, you poser, and you Huxley, too.

fb

 

Re: the only way out

Posted by morgan miller on April 18, 2011, at 12:01:08

In reply to Re: the only way out » poser938, posted by huxley on April 18, 2011, at 6:07:41

> poser,
>
> You have come to the wrong place man.
>
> Check out paxilprogress.com
>
> You will find people who have quit SSRIs and suffer for up to 5 years before recovering. They all mention anhedonia and they all recover eventually.
>
> I strongly suggest you go there and check it out before you listen to anyone here. Contrary to popular belief they don't know what they are talking about.
>
> You know what I have found, even the real pschiatirists dont know what they are doing. They are guessing, I have had several admit that.
>
> So why on earth would you listen to a bunch of anonymous people online talking about dopamine receptors.
>
> No one understands how the brain works or how these drugs effect them. All we can do is go of ancedotal evidence and sometimes our own is our best.
>
> Good luck with whatever you do.
>
>

Huxley, why do you keep coming back here if you have nothing to gain from any of the people here?

Look man, some people may have had bad experiences with SSRIs that sent them into a state worse than what they were before, I don't doubt that this is possible. Still, I believe there are far more people out there that have never had these issues with SSRIs and do well on them for the rest of their lives. You are going off of one internet site that attracts what is likely a smaller part of the population of people that have tried SSRIs than what it appears. Also, if one does not think their brain is quite the same after being on medication for a while, but they were doing fine on medication without ill side effects, than why not just stay on the darn medication and just live life? Big deal, you wake up in the morning, take your antidepressant, feel good, and get on with life, it's really that simple. Now for those that had a bad experience on an antidepressant or other medicaition, I suggest doing lots of research in an attempt to find medications that are less invasive and more likely to be effective. Medication should be combined with supplements, diet, exercise, meditative stretching/yoga, meditation, and therapy. Why would you want to suffer for five years of your life hoping that your brain function will return to normal(it may not because mental illness itself may prevent it from) when you could find ways to feel good again with the right medication. I sure as heck would not feel as good as I do right now if I had not given Lexapro a full 3 months and added a moderate dose of Depakote to it. I also take supplements that are helping, one of them being Piracetam(really a drug), and I just started exercising 3 times a wk(will be 4 or 5 soon).

You do realize there is some pretty good scientific evidence for chronic depression, anxiety, and bipolar states to cause alterations in chemistry and damage in parts of the brain, do you not? Medications may actually be useful in healing parts of the brain as some may be neuroprotective and also assist in repairing parts of the brain damaged by mental illness, and, possibly even parts of the brain damaged by previous medication use. It really is all dependent on the kinds of medications used. I think it would be silly to deny at least a trial of something like a low dose of lithium for those that experience depression and mixed states as lithium may protect the brain and help restore it at the same time. Lithium is not a synthesized in the lab medication, it comes straight from the earth. Lithium just needs to be bonded with something to help deliver it more like it would be delivered if we got it from nature-water or vegetables. There has been a study that showed cities with higher levels of lithium in the water had lower crime rates and lower suicide rates.

As I recall, you were on Zyprexa, which I consider to be a very invasive medicaiton. I've been off Zyprexa for a year now and I am so so glad I'm not taking it anymore.

>No one understands how the brain works or how these drugs effect them.

Well, you are wrong about this for sure. We may not know everything that medications do, but we have a good idea, and this is a result of legitimate research studies, what some of the main mechanisms of actions of medications are.
I believe it is a bit ridiculous to just ignore at least what we do know of science and simply always go off of anecdote.

Huxley, you obviously had a bad experience with some pretty heavy duty medications. Do you think it's possible that with the right medications you would eventually feel and function just fine and go on living a fairly happy life? All I'm saying is, don't knock it till you've tried it(and I'm not talking about awful drugs like Zyprexa).

How are you doing these days?

Morgan

 

Re: the only way out

Posted by linkadge on April 18, 2011, at 16:11:48

In reply to Re: the only way out » huxley, posted by SLS on April 18, 2011, at 6:30:55

Yes, some people do experience the protracted withdrawl symptoms. It took me about a year off celexa before I felt back to 100% normal. However, I still needed medication at the time to get back to normal.

I think withdrawl symptoms exist, but at the same time, normal people don't take antidepressants.

Its like going to get your first pair of glasses and putting them on. If you stop wearing them after a few months you will notice your eyes are worse, becuase they havn't had to work as hard to focus. Thats not a reason to bash glasses. If you really want to get back to your preglasses state, it will take a long time of sqiniting.

The bottom line is have a problem or you don't. Sometimes taking medications convince people that there was never a problem to begin with. That can be dangerous because they can't understand why they don't feel well off the drugs. If you need glasses, you're never going to see 100% without them (or contacts / laser surgury.. yadia).

Linkadge


 

Re: the only way out

Posted by linkadge on April 18, 2011, at 16:15:10

In reply to Re: the only way out, posted by morgan miller on April 18, 2011, at 12:01:08

I would hazzard to guess that those who experience the most severe and prolonged withdrawl symptoms probaby had the most pronounced depressive syptoms to begin with.

I know a friend who took 40mg of paxil for relatively mild anxiety. He stopped in a week (had withdrawl, but said it "wasn't too bad") so it really depends.

Linkadge

 

Re: the only way out » linkadge

Posted by floatingbridge on April 18, 2011, at 17:18:31

In reply to Re: the only way out, posted by linkadge on April 18, 2011, at 16:15:10

> I would hazzard to guess that those who experience the most severe and prolonged withdrawl symptoms probaby had the most pronounced depressive syptoms to begin with.
>
>
> Linkadge
>
Since reading about fibromyalgia, there
seems to be a consensus that as a population, these patients are very med-sensitive across the board. (There is no consensus regarding what fibromyalgia actually is, however.) Then there are those who present with depression years before fibromyalgia. Sigh.

Which doesn't disprove your guess. Some people theorize that depression (somatic) was afoot before fibromyalgia. I do know some folks w/ it who had some nice, undepressed lives before it.

Then, I think it's too easy an equation to say the more severe the illness, the more
protracted the withdrawal.

(I would, unfortunately, be a fine example if your first guess was correct :-/ .)

fb

 

question, Re: the only way out » SLS

Posted by floatingbridge on April 18, 2011, at 17:33:46

In reply to Re: the only way out » poser938, posted by SLS on April 18, 2011, at 5:52:41

> You are right about cyproheptadine. It is considered an anti-serotonergic that blocks 5-HT2a and 5-HT2b receptors. This in turn increases dopaminergic activity in various regions of the brain, including the prefrontal cortex - an area important for cognition and mood. Interestingly, 5-HT2a receptor binding is increased in suicide victims. This upregulation might indicate a decrease of serotoninergic activity in the PFC. This is in contrast to the mood-lifting properties of antipsychotics that block 5-HT2a receptors.
>

Scott, I'm having difficulty parsing this information out and applying to my own situation, one in which AP's (limited experience) make me feel worse.

So a 5-HT2a receptor binding agent is the same way of saying anti-serotegenic agents in the above paragraph? Obviously I'm not following. (It's me.)

And remeron? I haven't tried it. A friend considers it a cornerstone in her sustained recovery.

Thanks

> Linkadge is very capable.

Yes! :D

fb


He is an amazing resource for information. I'm sure he will correct my errors and expand upon what I have said.
>
> Have you ever tried Remeron?
>
> I'm glad you are now in a more positive and constructive state of mind. This is a heroic effort in view of the frustration and pain you must endure. Keep it up and continue to think creatively.
>
> Suicide is a way out for which there is no way back in.
>
> There is actually a neurobiology for suicidality. Anger and anxiety make it worse. In other words, there is the possibility that you are currently wired biologically to *feel* suicidal. When this is combined with having to manage a depressing situation, things get dangerous. You might need to start looking at this feeling of suicidality to be artificially produced by a dysfunction brain. Self-talk that recognizes these false fellings might help. It has helped me, especially when I have had bad reactions to medications. I avoid making decisions while in this state.
>
>
>
> - Scott
>
>
>
>
>
> > i stopped going to one because he said there was nothinng else he could do.. and my new one prescribed me celexa(ssr) which is the 1st thing thats usually tried im sure you know. its the only ssri i havent taken and the other ones numbed me to different extents. ive tried wellbutrin and it has a different numbing effect on me than SSRI's.
> > Well i'll tell you a bit of my psych history.
> > in 2005 when i 1st saw a psych he prescribed me cymbalta and adderall. after about a month my tolerance grew to adderall completely to 20mgs XR so i tried taking 2 of them and i still could not feel it one bit. usually people can up their dose and get and effect but i got nothing. i also ended up with anhedonia/extreme anxiety from that combo.. i suffered for a year and then gave and tried effexor and it made me sooooo NUMB! so i tried adderall again and still got no effect from it at all even tho it had been a year.
> > a few days later i asked my doc for cyproheptadine to help with effexor side effects. so i took it, slowly increasing the dose week for about a month..and then all the sudden my anhedonia had gone away. i could feel adderall again, and i was much less numb... but still pretty numb.
> >
> > 2 years went by and then i finally went to a medical doc to see if anything could take away all the numbness and thats when i was given mirapex. after a month and a half i ended up with anhedonia from it. thats when i realized adderall had caused my anhedonia in the past. so i tried cyproheptadine again, it helped quite a bit again, but i ended having to take too high a dose of it this time and had to stop taking it, unfortuanately.. and ive slowly gotten worse since i stopped taking it in december 2010. im going to get some more of the cyproheptadine tuesday to see if my tolerance has gone down to it yet. i storngly believe cyproheptadine affects dopamine receptors by upregulating them/ sensitiziing them in some way. and that increases the release of dopamine. i dont get how, im just positive it does.
> >
> > sorry if some of this sounds unclear, i can seriously not think straight .
>
>

 

Re: the only way out » floatingbridge

Posted by linkadge on April 18, 2011, at 18:32:58

In reply to Re: the only way out » linkadge, posted by floatingbridge on April 18, 2011, at 17:18:31

I'm not saying its true for everbody, but it just stands to reason that if your brain is more f'd up before meds, it will probably be f'd up (to some degree) after stopping.

Linkadge

 

Re: question, Re: the only way out

Posted by linkadge on April 18, 2011, at 18:38:14

In reply to question, Re: the only way out » SLS, posted by floatingbridge on April 18, 2011, at 17:33:46

Cortisol (stress?) increases the expression of excitory 5-ht2a receptors and decreases the expression of inhibitory 1a receptors. As a result, there is excessive glutamatergic activity in the cerebral / prefrontal corticies.

5-ht2a blocking AD's will reduce some of the enhanced activity at 5-ht2a receptors. But, it might take some time till the receptors actually decrease in expression.

SSRI's take some time to decrease 5-ht2a expression and in the mean time might make anxiety worse by activating these receptors. Combining with a 5-ht2a blocking agent, might have theraputic utlilty by decreasing the effect of the oversensitive receptors untill they decrease in affinity.

Basically, one theory is that its the ballance of 5-ht1a / 2a that is off in heightened anxiety / suicidality especially.


Linkadge

 

Re: the only way out

Posted by huxley on April 18, 2011, at 18:42:35

In reply to Re: the only way out, posted by morgan miller on April 18, 2011, at 12:01:08

Wow so many questions. Couldnt be bother answering them all.

I will answer one, Why do I come back here?

Beacause I hope to stop people getting put on drugs such as Risperdal, Zyprexa and Seroquel from casual advise from internet psychiatrists.

Maybe poser938 is one of these people who is suffering heavily from SSRI withdrawal. Something worth looking into.

I am well MM thanks for asking.
Still stuck on Zyprexa but I am getting of it slowly.


Im doing pretty well MM thanks for asking.

 

Re: the only way out

Posted by sigismund on April 18, 2011, at 18:49:56

In reply to Re: the only way out » floatingbridge, posted by linkadge on April 18, 2011, at 18:32:58

It makes sense to me that the more you need a drug, the harder it will be to stop, and maybe the more you should avoid it.

Not always, but sometimes.

For example anxious people might be better off avoiding benzos.

They might be better off trying TCM. I would have been.

 

Re: the only way out » sigismund

Posted by SLS on April 18, 2011, at 19:05:37

In reply to Re: the only way out, posted by sigismund on April 18, 2011, at 18:49:56

> It makes sense to me that the more you need a drug, the harder it will be to stop, and maybe the more you should avoid it.
>
> Not always, but sometimes.
>
> For example anxious people might be better off avoiding benzos.
>
> They might be better off trying TCM. I would have been.


What is TCM?


- Scott

 

Re: the only way out » huxley

Posted by floatingbridge on April 18, 2011, at 20:31:17

In reply to Re: the only way out, posted by huxley on April 18, 2011, at 18:42:35

Well, Huxley, I hear you on that one.

Seroquel ER (or XR or CR) is being advertised as a first line treatment for depression. I find that disturbing.

I can't imagine being given that when walking into a doctor's office right off the bat.

Then there is the big fat socio-economic problem of lots of kids being given ap's in the United States. Without parents being fully aware.

Thanks for answering. And good luck.

fb

 

Re: the only way out » SLS

Posted by floatingbridge on April 18, 2011, at 20:34:57

In reply to Re: the only way out » sigismund, posted by SLS on April 18, 2011, at 19:05:37

Traditional Chinese Medicine.

Maybe when I was.... No I was 20 when I tried it--but I'm intractable :-P

Or incorrigible.

It helps me though. Some other folks it can really help.

 

Re: the only way out » SLS

Posted by sigismund on April 18, 2011, at 21:13:39

In reply to Re: the only way out » sigismund, posted by SLS on April 18, 2011, at 19:05:37

Traditional Chinese Medicine.

When I was a kid I was quite frightened, but not badly so, just kind of obviously so. It would have been better for me to be offered TCM formulations than Valium in the 70s. It does the same thing in a more gentle way (at receptor sites), but it didn't really exist here then.

If parents can be persuaded to do what is necessary to stop tormenting their children, that might be effective too.

 

Re: the only way out » floatingbridge

Posted by sigismund on April 18, 2011, at 21:15:41

In reply to Re: the only way out » SLS, posted by floatingbridge on April 18, 2011, at 20:34:57

Best to try it before you are damaged too much by pharmaceuticals.

In my case that is chronic benzo use, so the things they have to calm you down work very gently on me.

 

Re: question, Re: the only way out

Posted by floatingbridge on April 18, 2011, at 21:22:29

In reply to Re: question, Re: the only way out, posted by linkadge on April 18, 2011, at 18:38:14

Link, thanks. Hence the warnings posted about suicidal behavior at the onset of ssri use, yes?

(I wonder why young brains are more susceptible? Perhaps because executive functioning is proposed to mature by 24 or so....)

Methinks I'll be thinking some more.

fb

 

Re: the only way out

Posted by floatingbridge on April 18, 2011, at 23:37:05

In reply to Re: the only way out » SLS, posted by sigismund on April 18, 2011, at 21:13:39

> Traditional Chinese Medicine.
>
I apologize for answering for you.

> When I was a kid I was quite frightened, but not badly so, just kind of obviously so.

You were? :( My kid is fearful and anxious at times. I worry. This reminds me that his TCM sessions have lapsed.


>It would have been better for me to be offered TCM formulations than Valium in the 70s. It does the same thing in a more gentle way (at receptor sites), but it didn't really exist here then.
>

> If parents can be persuaded to do what is necessary to stop tormenting their children, that might be effective too.


I'm still trying to figure this one out. :-/

I suppose by 20 I was already on my way to h*ll in a handcart.


 

Re: the only way out

Posted by morgan miller on April 19, 2011, at 1:39:20

In reply to Re: the only way out, posted by floatingbridge on April 18, 2011, at 23:37:05

> > Traditional Chinese Medicine.
> >
> I apologize for answering for you.
>
> > When I was a kid I was quite frightened, but not badly so, just kind of obviously so.
>
> You were? :( My kid is fearful and anxious at times. I worry. This reminds me that his TCM sessions have lapsed.
>
>
> >It would have been better for me to be offered TCM formulations than Valium in the 70s. It does the same thing in a more gentle way (at receptor sites), but it didn't really exist here then.
> >
>
> > If parents can be persuaded to do what is necessary to stop tormenting their children, that might be effective too.
>
>
> I'm still trying to figure this one out. :-/
>
> I suppose by 20 I was already on my way to h*ll in a handcart.
>
>
>

FB, I believe there is a way out for you in the future. Do you think it is possible you may be holding on to things and you've held on to them for so long you no longer know how to let go, and this may be holding you back from healing?

Don't get me wrong, I think the right medication treatment is going to be absolutely necessary, I just think there may be some other deep seated factors largely at play here. I'm thinking of a very integrative approach to healing.

Morgan

 

Re: the only way out

Posted by morgan miller on April 19, 2011, at 1:42:06

In reply to Re: the only way out » floatingbridge, posted by sigismund on April 18, 2011, at 21:15:41

> Best to try it before you are damaged too much by pharmaceuticals.
>
> In my case that is chronic benzo use, so the things they have to calm you down work very gently on me.

I think chronic benzo use comes second only to chronic antipsychotic use as the most damaging and counter productive treatments for a large part of the mentally ill population.

Ayervedic medicine is probably just as important and effective as TCM is. A combination of the two would be ideal.

 

Re: the only way out » sigismund

Posted by SLS on April 19, 2011, at 5:19:43

In reply to Re: the only way out » SLS, posted by sigismund on April 18, 2011, at 21:13:39

> Traditional Chinese Medicine.
>
> When I was a kid I was quite frightened, but not badly so, just kind of obviously so. It would have been better for me to be offered TCM formulations than Valium in the 70s. It does the same thing in a more gentle way (at receptor sites), but it didn't really exist here then.
>
> If parents can be persuaded to do what is necessary to stop tormenting their children, that might be effective too.

Unfortunately, this is true. Most people don't appreciate the unhealthy changes that can occur in a maturing brain when it is subject to unhealthy surroundings. This is especially true when chronic psychosocial stress is present. Of course, some people are wired to be less resilient than others. It is true that depression runs in families. However, so are pathological behaviors. They are often learned and passed on from generation to generation. If the rate of biological predisposition to depression is 10%, perhaps only 1% would develop the illness if everyone were raised in a low-stress, nurturing environment. 1% is probably an exaggeration, but it serves to make the point. The 10% is probably accurate.


- Scott

 

Re: the only way out

Posted by poser938 on April 19, 2011, at 8:10:08

In reply to Re: the only way out, posted by morgan miller on April 19, 2011, at 1:39:20

so i guess there are no thoughts on what could fix what the mirapex did to me? i guess what it did was kind of like a tolerance thing. that it stimulated my receptors to where they're not tolerant of dopamine anymore. i know they're not because i tried ritalin and tianeptine in the past hoping they would help, they only made me worse.. ritalin made me worse after just one dose. i've been trying DXM (dextromethorphan) at 60mgs a day lately to see if it would help, but hasnt at all so far. its been a week since i started.

 

Re: the only way out » poser938

Posted by SLS on April 19, 2011, at 8:29:50

In reply to Re: the only way out, posted by poser938 on April 19, 2011, at 8:10:08

> so i guess there are no thoughts on what could fix what the mirapex did to me? i guess what it did was kind of like a tolerance thing. that it stimulated my receptors to where they're not tolerant of dopamine anymore. i know they're not because i tried ritalin and tianeptine in the past hoping they would help, they only made me worse.. ritalin made me worse after just one dose. i've been trying DXM (dextromethorphan) at 60mgs a day lately to see if it would help, but hasnt at all so far. its been a week since i started.


Perhaps Abilify would stabilize your DA synapses. It is part DA agonist and part DA antagonist. It also may increase DA activity in PFC via 5-HT2a receptor antagonism.

http://www.ncbi.nlm.nih.gov/pubmed/11775041

http://altcancerweb.com/bipolar/abilify/abilify-illustrating-their-mechanism-of-action-stahl.pdf

http://www.ncbi.nlm.nih.gov/pubmed/17205315


- Scott


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