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Dr. Bob is Robert Hsiung, MD,
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Posted by Phillipa on October 17, 2010, at 13:05:15
May be time to start drinking again according to studies linking moderate drinking to increased cognition. Surprising? Phillipa
Moderate Wine Drinking Linked to Preserved Cognitive Function
News Author: Megan BrooksMegan Brooks
Megan Brooks is a freelance writer for Medscape.
Disclosure: Megan Brooks has disclosed no relevant financial relationships.Brande Nicole Martin
CME Clinical Editor, Medscape, LLC
Disclosure: Brande Nicole Martin has disclosed no relevant financial relationships.Laurie Barclay, MD
Freelance writer and reviewer, Medscape, LLC
Disclosure: Laurie Barclay, MD, has disclosed no relevant financial relationships.
September 14, 2010 In a Norwegian long-term population-based study, moderate wine drinkers had better cognitive test scores after 7 years' follow-up compared with teetotalers and those who rarely drank alcohol, researchers report in the July issue of Acta Neurologica Scandinavica."Our observations support results from other studies which indicate that light-to-moderate wine consumption could protect against cognitive decline and possibly also vascular and Alzheimer's dementia," first author Kjell A. Arntzen, MD, from the departments of Community Medicine and Neurology, University of Tromsų, Norway, and colleagues conclude.
Reached for independent comment on the study, Mary Ganguli, MD, MPH, professor of psychiatry, neurology, and epidemiology at University of Pittsburgh, Pennsylvania, said: "I don't think there is anything dramatically new here, but the study is quite detailed, with a nice big sample, nice long follow-up, [and] breaks down alcohol use into many categories, so it does help build the argument."
Wine Neuroprotective
Dr. Arntzen and colleagues examined the relationship over 7 years between intake of alcoholic beverages (beer, wine, and spirits) and cognitive function in 5033 stroke-free men and women. The mean age was 58.2 years for the 2806 women in the study and 58.8 years for the 2227 men.
Cognitive function was assessed using 3 standardized tasks: the 12-word memory test, the digit-symbol coding test, and the tapping test. These tasks were chosen, the authors explain, because of their "ability to detect early cognitive decline and their feasibility as screening tests in an epidemiological setting with a large number of participants."
In terms of alcohol consumption, 11.1% of men and 23.1% of women were teetotalers. The majority of subjects reported low alcohol intake (<1 glass/14 days, the reference group); 19.9% of men and 29.9% women drank at this level. The median alcohol intake was 1 drink per 14 days in women and 3 drinks in men. On average, only 1.9% of men and 0.2% of women had more than 2 drinks daily.
According to the investigators, increasing consumption of wine was significantly associated with better cognitive performance at follow-up in both men and women (P for trend ranging from .0003 to .04 in men, and from <.0001 to .002 in women).
In men, moderate beer consumption was also associated with better scores on 2 of the cognitive tests, the authors note, "but the differences in estimates were inconsistent." There was no consistent association between drinking spirits and performance on the cognitive tests.
Women who abstained from alcohol during follow-up had significantly worse cognitive performance compared with those with low alcohol consumption.
Potential Mechanisms
There are several possible explanations for the apparent cognitive benefits of moderate alcohol consumption noted in this study and others, Dr. Arntzen and colleagues note. For instance, studies have shown that light to moderate alcohol intake may protect against ischemic stroke and magnetic resonance imagingdetected white matter lesions, which suggests that the protective effects of alcohol on cognitive function are partly effected through vascular mechanisms, they write.
Flavonoids in red wine may reduce oxidative stress, which is thought to play a role in Alzheimer's disease by the formation in the brain of amyloid-beta protein, abnormal tau protein, and DNA damage in neurons. In the Canadian Study of Health and Aging, the team notes, moderate intake of wine, but not beer or spirits, halved the risk for Alzheimer's disease after 5 years of follow-up.
Clinically, neurologists and psychiatrists are much more used to dealing with the effects of excessive alcohol use.
"There is a lot of public health evidence on the benefits to both heart and brain of light to moderate alcohol use," Dr. Ganguli told Medscape Medical News. However, "clinically, neurologists and psychiatrists are much more used to dealing with the effects of excessive alcohol use. In addition, alcohol can interact with many of the medications we prescribe, so by and large, we are not in the habit of recommending alcohol use in, for example, the way we recommend physical exercise."Nonetheless, Dr. Ganguli said, "there is clearly a consistent signal here that should be followed up."
Dr. Arntzen's team notes in their report that an upper limit for the positive effect of wine intake could not be determined because of the very few participants in this study with high alcohol intakes.
A lack of information on baseline cognitive function made it impossible to assess how alcohol intake may influence cognitive decline. Limited available information on socioeconomic status and possible differences in unmeasured lifestyle variables between drinkers and nondrinkers are also limitations.
"Because of cohort effects, results may not apply to younger generations with other drinking habits," they add.
The study authors and Dr. Ganguli have disclosed no relevant financial relationships.
Acta Neurol Scand. 2010;122:23-29.
Additional Information
More information about the health risks and benefits of alcohol intake is available online from Harvards School of Public Health
Posted by glydin50 on October 17, 2010, at 16:53:49
In reply to Moderate Drinking Linked To Improved Cognition, posted by Phillipa on October 17, 2010, at 13:05:15
In the effort for safety, in particular for a psych medication board, please note this quote in above cut and paste article:
"In addition, alcohol can interact with many of the medications we prescribe"
And it's always good to keep in mind the initial caveat of this board, nothing posted is guarenteed accurate or fitting for all's circumstances. Thx
Posted by PartlyCloudy on October 18, 2010, at 12:42:31
In reply to Re: Moderate Drinking *Please note quote*, posted by glydin50 on October 17, 2010, at 16:53:49
> In the effort for safety, in particular for a psych medication board, please note this quote in above cut and paste article:
>
> "In addition, alcohol can interact with many of the medications we prescribe"
>
> And it's always good to keep in mind the initial caveat of this board, nothing posted is guarenteed accurate or fitting for all's circumstances. Thx
>
>Thanks for this - such good sense. Drinking sure did prevent my medications from doing their work properly, no matter the amount of consumption. Moderate drinking sounds like a good idea for those of us who are taking drugs that don't advise against alcohol.... and I haven't taken such a cocktail (pardon the pun) for many, many years.
pc
Posted by Phillipa on October 18, 2010, at 19:26:04
In reply to Re: Moderate Drinking *Please note quote* » glydin50, posted by PartlyCloudy on October 18, 2010, at 12:42:31
Yes the key is to discuss it with your doctor who knows you and your meds. And PC congrats to you. I know you struggled. But came out on top!!!! Phillipa
Posted by Maxime on October 18, 2010, at 21:10:41
In reply to Re: Moderate Drinking *Please note quote* » PartlyCloudy, posted by Phillipa on October 18, 2010, at 19:26:04
> Yes the key is to discuss it with your doctor who knows you and your meds. And PC congrats to you. I know you struggled. But came out on top!!!! Phillipa
I don't know. Do you think that any doctor would advocate drinking alcohol with meds?
Posted by Phillipa on October 18, 2010, at 21:20:01
In reply to Re: Moderate Drinking *Please note quote* » Phillipa, posted by Maxime on October 18, 2010, at 21:10:41
Maxie start a thread people will answer yours. Would be a really good one. Phillipa
Posted by ed_uk2010 on October 18, 2010, at 23:14:29
In reply to Re: Moderate Drinking *Please note quote*, posted by glydin50 on October 17, 2010, at 16:53:49
Perhaps we should be drinking grape juice instead for the antioxidants. I like grape juice anyway so I don't need an excuses to drink it.
Posted by Glydin50 on October 18, 2010, at 23:20:15
In reply to Re: Moderate Drinking *Please note quote* » glydin50, posted by ed_uk2010 on October 18, 2010, at 23:14:29
Grape juice is delicious! White, purple or red... I don't need an excuse for it either. If we ever find ourselves anywhere close to one another I owe ya a toast w/ just that : )
Posted by sigismund on October 19, 2010, at 0:02:08
In reply to Re: Moderate Drinking *Please note quote* » Phillipa, posted by Maxime on October 18, 2010, at 21:10:41
>Do you think that any doctor would advocate drinking alcohol with meds?
My psych told me to be very careful not to drink too much less.
Posted by morgan miller on October 19, 2010, at 0:54:01
In reply to Re: Moderate Drinking *Please note quote* » glydin50, posted by ed_uk2010 on October 18, 2010, at 23:14:29
> Perhaps we should be drinking grape juice instead for the antioxidants. I like grape juice anyway so I don't need an excuses to drink it.
I used to think that too, until I found out that red wine has beneficial compounds that grape juice does not. I believe it has something to do using the skin of grapes in red wine and the fermentation process(and I'm not talking about the resulting alcohol). Eating whole concord grapes with the skin would give you something closer to the benefits of red wine.
Posted by ed_uk2010 on October 19, 2010, at 13:23:46
In reply to Re: Moderate Drinking *Please note quote*, posted by morgan miller on October 19, 2010, at 0:54:01
>I used to think that too, until I found out that red wine has beneficial compounds that grape juice does not.
Oh well I drink plenty of both so I guess I should be OK :)
Posted by ed_uk2010 on October 19, 2010, at 13:24:23
In reply to Re: Moderate Drinking *Please note quote* » Maxime, posted by sigismund on October 19, 2010, at 0:02:08
> >Do you think that any doctor would advocate drinking alcohol with meds?
>
> My psych told me to be very careful not to drink too much less.Lol. I don't know whether to believe you but if so, that's very funny.
Posted by sigismund on October 19, 2010, at 16:46:58
In reply to Re: Moderate Drinking *Please note quote* » sigismund, posted by ed_uk2010 on October 19, 2010, at 13:24:23
>Lol. I don't know whether to believe you but if so, that's very funny
Of course it's true, Eddy.
Posted by ed_uk2010 on October 19, 2010, at 17:24:55
In reply to Re: Moderate Drinking *Please note quote* » ed_uk2010, posted by sigismund on October 19, 2010, at 16:46:58
> >Lol. I don't know whether to believe you but if so, that's very funny
>
> Of course it's true, Eddy.Is he the sort of doc who offers a cigar? (I think this breed of psychiatrist may be extinct).
Posted by morgan miller on October 19, 2010, at 20:40:06
In reply to Re: Moderate Drinking *Please note quote* » sigismund, posted by ed_uk2010 on October 19, 2010, at 17:24:55
> > >Lol. I don't know whether to believe you but if so, that's very funny
> >
> > Of course it's true, Eddy.
>
> Is he the sort of doc who offers a cigar? (I think this breed of psychiatrist may be extinct).
>
>These last few posts made me smile, thanks : )
Posted by sigismund on October 20, 2010, at 2:09:14
In reply to Re: Moderate Drinking *Please note quote* » sigismund, posted by ed_uk2010 on October 19, 2010, at 17:24:55
>Is he the sort of doc who offers a cigar?
Fraid not.
He just has a great deal of skepticism about modern psychiatry and the pharmaceutical tie-up.
Which is to say I suppose that he does not seem to privilege psych drugs over any others, or so it seems.
He uses psych drugs, though conservatively.
Posted by morgan miller on October 20, 2010, at 11:27:26
In reply to Re: Moderate Drinking *Please note quote* » ed_uk2010, posted by sigismund on October 20, 2010, at 2:09:14
> >Is he the sort of doc who offers a cigar?
>
> Fraid not.
>
> He just has a great deal of skepticism about modern psychiatry and the pharmaceutical tie-up.
>
> Which is to say I suppose that he does not seem to privilege psych drugs over any others, or so it seems.
>
> He uses psych drugs, though conservatively.I want to see your psychiatrist.
Posted by ed_uk2010 on October 20, 2010, at 13:37:01
In reply to Re: Moderate Drinking *Please note quote* » ed_uk2010, posted by sigismund on October 20, 2010, at 2:09:14
> >Is he the sort of doc who offers a cigar?
>
> Fraid not.
>
> He just has a great deal of skepticism about modern psychiatry and the pharmaceutical tie-up.
>
> Which is to say I suppose that he does not seem to privilege psych drugs over any others, or so it seems.
>
> He uses psych drugs, though conservatively.There's no shortage of things to be skeptical about.
Posted by Maxime on October 20, 2010, at 21:35:28
In reply to Re: Moderate Drinking *Please note quote* » glydin50, posted by ed_uk2010 on October 18, 2010, at 23:14:29
> Perhaps we should be drinking grape juice instead for the antioxidants. I like grape juice anyway so I don't need an excuses to drink it.
I LOVE grapejuice. I love when it gives a purple moustache! I am a child a heart. :)
Posted by ed_uk2010 on October 21, 2010, at 13:12:15
In reply to Re: Moderate Drinking *Please note quote* » ed_uk2010, posted by Maxime on October 20, 2010, at 21:35:28
> > Perhaps we should be drinking grape juice instead for the antioxidants. I like grape juice anyway so I don't need an excuses to drink it.
>
> I LOVE grapejuice. I love when it gives a purple moustache! I am a child a heart. :)You should take a photo and email me!
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