![[dr. bob]](/dr-bob-sm.gif)
Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 16 of 16. This is the beginning of the thread.
Posted by jedi on April 30, 2010, at 12:55:24
Hi Guys, I had to have hip replacement surgery and have been off Nardil for about a month. Oxycodone has kept the depression in check, but just wondering if anyone has had luck lately with any new medications for treatment resistant, atypical depression with social anxiety. I'm still taking 2 mg of clonazepam daily, but am washed out on the MAOI and thought it might be a good chance to take another go at getting off Nardil. I've tried this so many times now, it makes my head spin. 45+ different combinations of medications of all classes, except the stimulants. Every time I end up going back on the Nardil when the major depression returns, usually within about 3 months. Gives me a small window to play with. Every time I try this, and go back to Nardil, I say I'm going to be a lifer. But I keep trying.
It has been said that, "The definition of insanity is doing the same thing over and over again and expecting different results." But times and situations change. It would be so nice to be drug free, or at least not have to worry about all of the side effects of the MAOIs.
Any suggestions, or personal experiences would be appreciated.
Thanks,
Jedi
Posted by Phillipa on April 30, 2010, at 13:29:35
In reply to MAOI replacement options, posted by jedi on April 30, 2010, at 12:55:24
Jedi hoping Stargazer sees this as she has good results on ADD meds. Hoping the pain is much better. Love Phillipa
Posted by conundrum on April 30, 2010, at 20:46:53
In reply to MAOI replacement options, posted by jedi on April 30, 2010, at 12:55:24
From what I hear Nardil is the sh*t for depression. Is there a problem with taking it or are you just concerned that you might have interaction if you had to have a major surgery?
My grandmom took it for 30 years and never had any problems. I would say though that it can be bad in an emergancy, so I would stay away from any really extreme activities and wear a bracelet.
Most of the newer drugs just make people numb as you can see in many of the threads here. Just becareful and you'll be fine. If you ever need a surgery again or suspect you might just ween off so that the anesthesiologist has lots of options.
Just my 2 cents. That or find a psych who will keep prescribing opiates. It might be possible if you could convince them its safer than Nardil.
Posted by stargazer2 on May 1, 2010, at 10:36:09
In reply to MAOI replacement options, posted by jedi on April 30, 2010, at 12:55:24
Hi,
You and I are in the exact situation. I'm now off Nardil with the thought to resume a trial of meds to include a stimulant. Besides MAO's, the only other success of any type in the 20+ years of being on meds has been a combo of Wellbutrin, Celexa and Adderall (about 5-7 yrs ago).
I don't think it was so much the Celexa and/or Wellbutrin but the addition of Adderall that made a difference.
My new trial will begin this week and I have a feeling we will try Adderall again as it has worked in the past.
My experimentation with Nardil and a tiny dose of generic Adderall was positive but my doc was never on board with the Nardil/Stim combo. Just to convince him to add wellbutrin (which I'm still on) to Nardil took an act of Congress and was based on research I had done.
But in any event, that is my plan. I thought somewhere I had noted that you had memory and concentration issues but then today I don't see those under your profile. I actaully responded last night to you but unfortunately the post never went thru. This is my followup post as I wanted to answer you right away.
Any ideas for your next meds? I would definately suggest a stim if you have never tried one,as it might be the key for you as well.
I'll follow this post and we can work on our next steps with eachother's help/advice.
Thanks.
SG2
Posted by jedi on May 1, 2010, at 12:36:58
In reply to Re: MAOI replacement options/Jedi, posted by stargazer2 on May 1, 2010, at 10:36:09
Hi SG2,
Sounds like we are very similar. Yes, I have had memory and concentration issues which I blamed on the long term clonazepam use. I actually was on Nardil (90 mg) with bupropion(300 mg) for a long time. I actually prescribed it myself, after much study. Then I was able to get a PDOC to continue it, since it had done me no harm. Pharmacists went nuts. When the doctor who prescribed it retired, another PDOC immediately took me off the combo. I have never seen any data that they are harmful together. MDs like to read the PDR for medical information. It is, in fact, a legal handbook. I've never seen so much misinformation published in one source.I was really thinking a stimulant, because dopamine is the one neurotransmitter that has not been fully explored with me. The opiates sure have worked well short term, since my surgery. But then they have always been that way for me. I've cut back to 3 - 325 mg oxycodone per day, which really is not quite enough. I know that no one will prescribe it for my psychic pain, so why pursue that route. I really do believe that the opioid receptors in the brain are a clue for many of us who are treatment resistant. They were not put there just to make the drug dealers lots of money! LOL I know that many of the addicts, who get caught up on opioids, are self treating for depression. If handled by a knowledgeable MD, there could be a lot less suffering and a lot more WELL people out there. Here is an interesting little article which explains the difference between opiates and opioids (I digress): http://www.drugs-forum.com/opiates.html
I have the misfortune of living in a small community with a dismal ability to handle mental health issues. I went through the yellow pages and counted, I believe, 175 physicians in this little area. One psychiatrist is listed that a person can see if they are not on Medicaid or such. That one MD caters exclusively to the Hispanic community. I'm going to be driving 150 miles one way to find someone who knows more about medications for depression than I do. I don't think that is my inflated ego coming out. It is just a statement to the miserable ability of the medical community, in this area, to handle mental health issues.
I have never been able to talk my GP into trying even a micro dose of stimulant with Nardil. He won't even go modafinal. I can't blame him. I'm probably his only patient on MAOIs, I know I was his first. Before finding him and getting him to put me back on Nardil, so I could survive; I spent 9 months with a PDOC who absolutely refused to get me back on the one medication that had ever worked for me. He saw me as a risk, because I adjust my own medications. Well, the guy was an idiot, out to protect his own *ss and nothing else. I would have died before he would prescribe the Nardil, to save my life.
I've tried Parnate a couple of times. Unfortunately, the last time, I had a very rare, spontaneous, hypertensive episode. It may have been the answer, if not for the blood pressure issue.
I'm in the process of changing insurance. When that comes through, I will travel that 300 mile round trip to maybe find a replacement for Nardil. I think a stimulant may be the next try. I appreciate you responding. I have been through the lost post routine! Very frustrating. And I worked in computer programming for 15 years! How does a complete layperson even use one of these things?
I keep trying to get off Nardil because of the weight gain and sexual side effects. Insomnia is another big one for me, but that can be handled. My initial weight gain from the atypical depression and Nardil was over 100 pounds. I've taken off more than half of that, but have to get beyond this hip replacement to lose the rest of it. I know it would be so much easier without the carbohydrate cravings caused by Nardil. I can lose weight on Nardil, but it takes about two hours, five times per week, of intense exercise.
I know I can always go back to Nardil, unless they quit making it. It has wiped out the major depression every time in the past. It is hard, if in major depression, to make the calls necessary to get the medications that you need. If they made cancer or heart patients go through what they make us go through, there would be a lot more people dying.
Thanks again,
Jedi
> Hi,
>
> You and I are in the exact situation. I'm now off Nardil with the thought to resume a trial of meds to include a stimulant. Besides MAO's, the only other success of any type in the 20+ years of being on meds has been a combo of Wellbutrin, Celexa and Adderall (about 5-7 yrs ago).
>
> I don't think it was so much the Celexa and/or Wellbutrin but the addition of Adderall that made a difference.
>
> My new trial will begin this week and I have a feeling we will try Adderall again as it has worked in the past.
>
> My experimentation with Nardil and a tiny dose of generic Adderall was positive but my doc was never on board with the Nardil/Stim combo. Just to convince him to add wellbutrin (which I'm still on) to Nardil took an act of Congress and was based on research I had done.
>
> But in any event, that is my plan. I thought somewhere I had noted that you had memory and concentration issues but then today I don't see those under your profile. I actaully responded last night to you but unfortunately the post never went thru. This is my followup post as I wanted to answer you right away.
>
> Any ideas for your next meds? I would definately suggest a stim if you have never tried one,as it might be the key for you as well.
>
> I'll follow this post and we can work on our next steps with eachother's help/advice.
>
> Thanks.
>
> SG2
Posted by bulldog2 on May 1, 2010, at 12:38:19
In reply to MAOI replacement options, posted by jedi on April 30, 2010, at 12:55:24
> Hi Guys, I had to have hip replacement surgery and have been off Nardil for about a month. Oxycodone has kept the depression in check, but just wondering if anyone has had luck lately with any new medications for treatment resistant, atypical depression with social anxiety. I'm still taking 2 mg of clonazepam daily, but am washed out on the MAOI and thought it might be a good chance to take another go at getting off Nardil. I've tried this so many times now, it makes my head spin. 45+ different combinations of medications of all classes, except the stimulants. Every time I end up going back on the Nardil when the major depression returns, usually within about 3 months. Gives me a small window to play with. Every time I try this, and go back to Nardil, I say I'm going to be a lifer. But I keep trying.
>
> It has been said that, "The definition of insanity is doing the same thing over and over again and expecting different results." But times and situations change. It would be so nice to be drug free, or at least not have to worry about all of the side effects of the MAOIs.
>
> Any suggestions, or personal experiences would be appreciated.
>
> Thanks,
> Jedi
>Have you tried clomipramine? It's up there with the best.
Posted by jedi on May 1, 2010, at 12:45:52
In reply to Re: MAOI replacement options, posted by bulldog2 on May 1, 2010, at 12:38:19
Thanks for the suggestion Bulldog. I will do some research.
Be Well,
Jedi
Posted by bulldog2 on May 1, 2010, at 13:38:32
In reply to Re: MAOI replacement options, posted by jedi on May 1, 2010, at 12:45:52
> Thanks for the suggestion Bulldog. I will do some research.
> Be Well,
> Jedi
>Read justherself54 threads. She is on clomipramine and is pleasantly surprised. Nice serotonin action but smoother than an ssri and also good norepinephrine action. As far as tcas go I would say less sides than most. It's is strong and works for most and less sedating than most. iT is worth looking into. I would try nardil if it wasn't for the weight gain problems. It's a shame the old nardil is gone.
Good luck with the hip replacement. Mine went very smooth and the pain is gone. But now the other hips is going. Can't catch a break and sciatica from snow shoveling. You will have to work hard in rehab but it is worth it. We got cookies and juice every morning before we started for energy.
Good Luck
Bulldog
Posted by stargazer2 on May 1, 2010, at 19:02:40
In reply to Re: MAOI replacement options » jedi, posted by bulldog2 on May 1, 2010, at 13:38:32
Hi there...just curious...you both had THR's, what was the reason...osteo, injury? It has become such a common procedure for so many. I worked in Boston and took care of the first THR's there, in the 70's. Before the THR they did a girdlestone procedure which was removing the hip joint, boy have we come a long way since then.
Hip hip hooray, had to throw that out..it just popped into my brain, which is another story.
Posted by jedi on May 1, 2010, at 19:32:16
In reply to Re: MAOI replacement options/Jedi/Bulldog, posted by stargazer2 on May 1, 2010, at 19:02:40
Hi SG2,
Actually I had a procedure called a Birmingham Hip Resurfacing. It was needed because of advanced bone on bone arthritis. One surgeon wanted me to wait as long as I could before having a THR. The BHR is done on younger, more active patients, who may wear out a THR in their lifetime. It conserves the neck and most of the femoral head. This makes the procedure more technical since there is less room to position the acetabular component, and this is the most critical part of the operation. The procedure has only been FDA approved in the US since 2006, but my surgeon has done over 1500 of the operations, starting with the earlier product of the early 80's. The current BHR components are metal on metal cobalt/chromium alloy. I'm crossing my fingers that I made the right decision. I'm about 3.5 weeks out and walking fairly good. It was major/major surgery. Anyone want a pic, just babble-mail me.
Take care,
Jedi> Hi there...just curious...you both had THR's, what was the reason...osteo, injury? It has become such a common procedure for so many. I worked in Boston and took care of the first THR's there, in the 70's. Before the THR they did a girdlestone procedure which was removing the hip joint, boy have we come a long way since then.
>
> Hip hip hooray, had to throw that out..it just popped into my brain, which is another story.
Posted by bulldog2 on May 2, 2010, at 9:49:15
In reply to Re: MAOI replacement options/Jedi/Bulldog, posted by stargazer2 on May 1, 2010, at 19:02:40
> Hi there...just curious...you both had THR's, what was the reason...osteo, injury? It has become such a common procedure for so many. I worked in Boston and took care of the first THR's there, in the 70's. Before the THR they did a girdlestone procedure which was removing the hip joint, boy have we come a long way since then.
>
> Hip hip hooray, had to throw that out..it just popped into my brain, which is another story.
>
>Severe osteoarthritis of the left hip. It just comes down to pain. When you can no longer tolerate the pain,its time for the hip replacement. Now they use materials that are supposed to last the rest of your life.
Posted by Shyone on June 4, 2010, at 19:14:19
In reply to MAOI replacement options, posted by jedi on April 30, 2010, at 12:55:24
Hi Jedi,
I was recently admitted to the hospital for a very slow heartbeat where I had to get a pacemaker, and was forced to go off Nardil cold turkey after 30 years. The doctors felt this medication could have been the cause of my heart conduction defect, and if not, could be aggravating it. After being left on only 2 mg. of Lorazepam (1mg. twice daily), by day two of my four days spent in Coronary ICU, I was climbing the walls. I no longer was getting my 15 mg. also BID of Nardil and my body and brain were crying out for it. I begged my doctor to give me Xanax instead, and they allowed me to have 1/4 mg. of Xanax every 6 hours. I managed on one every 8 hours because of my fear of the addictive properties of Xanax.
I just started my 4th week on less than 1 mg. daily on Xanax and it seems to be controlling my anxiety and depression very well so far. I don't know what tomorrow might bring. I believe that this is because of the GABA that the Xanax maintains in our brain, which is the hormone that helps control our anxiety. With me, I feel that it was my uncontrollable anxiety that led to severe depression. I don't believe in taking a cocktail of drugs as one doctor I saw previously wanted to put me on because of all the side effects -- that can often feel worse than the condition they're supposed to treat.
But one of the things that did happen once I was off the Nardil was that my blood pressure shot up and has remained elevated. That's probably because I'm obviously no longer the age I was when I started taking Nardil, and over the years, we can develop hypertension (which runs strongly in my family). So my head still spins some, as my follow-up physician is trying to get it under control with some anti-hypertension medication. Have you had your BP checked lately? That could be your reason for feeling dizzy once you get off the Nardil. I'm sure you know that one of the side effects of Nardil is to lower the blood pressure. That's why the condition I was developing over the years didn't show up until I got off the Nardil. Also, my severe shyness (Social Anxiety) is no longer being maintained as well as with the MAO Inhibiting effect we get from Nardil. After all, this drug also maintains our Serotonin, Norepinephrine, and Dopamine levels even keel.
I hope this information will be helpful to you and others who read this post and who are terrified that they can't live without Nardil, as I was for 30 years.
Posted by Shyone on June 4, 2010, at 21:00:01
In reply to MAOI replacement options, posted by jedi on April 30, 2010, at 12:55:24
Hi Jedi,
It's me again. sorry, but I obviously misunderstood your point about having your head spinning from trying to get off the Nardil so many times. But just the same, I would still keep an eye on my blood pressure if I were you. Because high BP can cause anxiety, a rapid heart beat, dizziness, and many of the symptoms of panic attacks. Also the weight gain we get from being on Nardil for long periods can cause hypertension. And uncontrollable anxiety can then lead to what they call secondary depression. I wonder how many people who got into their 50's and even into their 60's while on Nardil developed this condition and became anxious after stopping the Nardil -- thinking everything they felt was psychological. What they could have been going through was "rebound hypertension," the same as going off blood pressure medication.
I also wrote on the Anxiety Community web site about a nurse in the hospital mentioning to me a condition that's seldom investigated by doctors called "Autonomic Dysfunction," or or "Dysautonomia," which can also cause symptoms such as anxiety, depression, and many other psychiatric disorders, and wich is rarely checked out by an endocrinologist to rule out physical causes. Unlike most doctors, if I had become a physician as I wanted to be since I was a little girl, I would be dedicated to finding and treating the cause of diseases rather than trying to control the symptoms. Unfortunately, there is a lot more money to be made in the latter.
And in case you decide to go back to Nardil and remain on it, I wanted to let you know that in the past, I had surgery that lasted over 6 hours (lyposuction), and 2 years ago had a disc problem from a quack chiropractor cracking my neck and smashing one of the discs in my neck. I was under for about 3 hours. And both times I didn't have to get off the Nardil. There are certain anesthetics that can be given safely while on Nardil, such as Propofol and Versed, if I remember correctly. There are also a few others. You'd have to find an anesthesiologist who's well informed on MAOIs. After all, there are times when someone will need emergency surgery, so they have to have some way of anesthetizing people taking irreversible MAOIs.
But just in case my depression returns anytime in the future, as you said happens with you after a three month period off the Nardil, my doctor is prepared to try me on a small dose of Wellbutrin, esp. because of its Dopaminergic effect. He might also add some Neurontin to prevent seizures that Wellbutrin can cause in some people. I happen to have a hypersensitive nervous system which is why I always seemed to respond on lower doses of medications than most people. I read in the past an authoritative article stating that people who suffer from panic disorder tend to not produce or process DOPAMINE as well as those who don't have the disorder, and that in fact they can later develop Parkinson's Disease because of this. Sorry! I didn't mean to scare you here,
;), but was just trying to share the information I came across through my own research. I also have been reading about some antidepressants and stimulant drugs causing heart damage over time, as my doctors in the hospital tried to tell me, which is another reason I'd like to avoid going back on an antidepressant unless my life depended on it. These are things to keep in mind when considering what medications to replace the Nardil with. Take care.
Posted by jedi on June 7, 2010, at 0:01:40
In reply to Re: MAOI replacement options, posted by Shyone on June 4, 2010, at 21:00:01
Hi Shyone,
I apologize for not responding sooner, I've been out of town for a few days. It is good to here from a long term Nardil user. I do have borderline high blood pressure and the Nardil has kept my BP low enough to stay off the beta blockers and ace inhibitors for ten years. One good side effect. I have been able to take off half the weight I gained from Nardil. I want to take off the other half now that my hip is healing.> It's me again. sorry, but I obviously misunderstood your point about having your head spinning from trying to get off the Nardil so many times. But just the same, I would still keep an eye on my blood pressure if I were you. Because high BP can cause anxiety, a rapid heart beat, dizziness, and many of the symptoms of panic attacks. Also the weight gain we get from being on Nardil for long periods can cause hypertension. And uncontrollable anxiety can then lead to what they call secondary depression. I wonder how many people who got into their 50's and even into their 60's while on Nardil developed this condition and became anxious after stopping the Nardil -- thinking everything they felt was psychological. What they could have been going through was "rebound hypertension," the same as going off blood pressure medication.
>I will do some research on this "Dysautonomia". I have never heard of it.
> I also wrote on the Anxiety Community web site about a nurse in the hospital mentioning to me a condition that's seldom investigated by doctors called "Autonomic Dysfunction," or or "Dysautonomia," which can also cause symptoms such as anxiety, depression, and many other psychiatric disorders, and wich is rarely checked out by an endocrinologist to rule out physical causes. Unlike most doctors, if I had become a physician as I wanted to be since I was a little girl, I would be dedicated to finding and treating the cause of diseases rather than trying to control the symptoms. Unfortunately, there is a lot more money to be made in the latter.
>I also have had surgery without washing out the Nardil, so I know it is not a problem with the right anesthesiologist. Rather than fight them on it, I knew from past experience that a short washout would not be a problem for me. Just went with the flow. These guys from the head surgeon on down probably got sick of me telling them I had only washed out the Nardil for two weeks before surgery. They had only suggested a week. All I needed was some uninformed nurse giving me a large dose of meperidine without being completely washed out on the Nardil.
> And in case you decide to go back to Nardil and remain on it, I wanted to let you know that in the past, I had surgery that lasted over 6 hours (lyposuction), and 2 years ago had a disc problem from a quack chiropractor cracking my neck and smashing one of the discs in my neck. I was under for about 3 hours. And both times I didn't have to get off the Nardil. There are certain anesthetics that can be given safely while on Nardil, such as Propofol and Versed, if I remember correctly. There are also a few others. You'd have to find an anesthesiologist who's well informed on MAOIs. After all, there are times when someone will need emergency surgery, so they have to have some way of anesthetizing people taking irreversible MAOIs.
>I've been on bupropion in the past, even in combination with Nardil. I've also been on gabapentin. Of the 45+ combinations of ADs and augmenters I've been on, only phenelzine and clonazepam have worked for me. I'm just going to have to cross my fingers that I don't end up with some kind of a heart poblem like you related in your previous post. I would really love for something else to work for me. so far, no go.
Thanks so much for your knowledge and information,
Jedi
> But just in case my depression returns anytime in the future, as you said happens with you after a three month period off the Nardil, my doctor is prepared to try me on a small dose of Wellbutrin, esp. because of its Dopaminergic effect. He might also add some Neurontin to prevent seizures that Wellbutrin can cause in some people. I happen to have a hypersensitive nervous system which is why I always seemed to respond on lower doses of medications than most people. I read in the past an authoritative article stating that people who suffer from panic disorder tend to not produce or process DOPAMINE as well as those who don't have the disorder, and that in fact they can later develop Parkinson's Disease because of this. Sorry! I didn't mean to scare you here,
> ;), but was just trying to share the information I came across through my own research. I also have been reading about some antidepressants and stimulant drugs causing heart damage over time, as my doctors in the hospital tried to tell me, which is another reason I'd like to avoid going back on an antidepressant unless my life depended on it. These are things to keep in mind when considering what medications to replace the Nardil with. Take care.
Posted by Murph on June 19, 2010, at 17:36:03
In reply to Re: MAOI replacement options » Shyone, posted by jedi on June 7, 2010, at 0:01:40
Has anyone heard anything one way or another about the triple reuptake inhibitors replacing Nardil. I've been on the s*it for 20 years. Monster when it comes to surgery and sex! Tried every thing my doc has come up with but all ended up leaving me in a major depressive episode and back on Nardil (weighing 70 lbs more than I did 20 years ago).
Murph
> Hi Shyone,
> I apologize for not responding sooner, I've been out of town for a few days. It is good to here from a long term Nardil user. I do have borderline high blood pressure and the Nardil has kept my BP low enough to stay off the beta blockers and ace inhibitors for ten years. One good side effect. I have been able to take off half the weight I gained from Nardil. I want to take off the other half now that my hip is healing.
>
> > It's me again. sorry, but I obviously misunderstood your point about having your head spinning from trying to get off the Nardil so many times. But just the same, I would still keep an eye on my blood pressure if I were you. Because high BP can cause anxiety, a rapid heart beat, dizziness, and many of the symptoms of panic attacks. Also the weight gain we get from being on Nardil for long periods can cause hypertension. And uncontrollable anxiety can then lead to what they call secondary depression. I wonder how many people who got into their 50's and even into their 60's while on Nardil developed this condition and became anxious after stopping the Nardil -- thinking everything they felt was psychological. What they could have been going through was "rebound hypertension," the same as going off blood pressure medication.
> >
>
> I will do some research on this "Dysautonomia". I have never heard of it.
>
> > I also wrote on the Anxiety Community web site about a nurse in the hospital mentioning to me a condition that's seldom investigated by doctors called "Autonomic Dysfunction," or or "Dysautonomia," which can also cause symptoms such as anxiety, depression, and many other psychiatric disorders, and wich is rarely checked out by an endocrinologist to rule out physical causes. Unlike most doctors, if I had become a physician as I wanted to be since I was a little girl, I would be dedicated to finding and treating the cause of diseases rather than trying to control the symptoms. Unfortunately, there is a lot more money to be made in the latter.
> >
>
> I also have had surgery without washing out the Nardil, so I know it is not a problem with the right anesthesiologist. Rather than fight them on it, I knew from past experience that a short washout would not be a problem for me. Just went with the flow. These guys from the head surgeon on down probably got sick of me telling them I had only washed out the Nardil for two weeks before surgery. They had only suggested a week. All I needed was some uninformed nurse giving me a large dose of meperidine without being completely washed out on the Nardil.
>
> > And in case you decide to go back to Nardil and remain on it, I wanted to let you know that in the past, I had surgery that lasted over 6 hours (lyposuction), and 2 years ago had a disc problem from a quack chiropractor cracking my neck and smashing one of the discs in my neck. I was under for about 3 hours. And both times I didn't have to get off the Nardil. There are certain anesthetics that can be given safely while on Nardil, such as Propofol and Versed, if I remember correctly. There are also a few others. You'd have to find an anesthesiologist who's well informed on MAOIs. After all, there are times when someone will need emergency surgery, so they have to have some way of anesthetizing people taking irreversible MAOIs.
> >
>
> I've been on bupropion in the past, even in combination with Nardil. I've also been on gabapentin. Of the 45+ combinations of ADs and augmenters I've been on, only phenelzine and clonazepam have worked for me. I'm just going to have to cross my fingers that I don't end up with some kind of a heart poblem like you related in your previous post. I would really love for something else to work for me. so far, no go.
> Thanks so much for your knowledge and information,
> Jedi
>
>
> > But just in case my depression returns anytime in the future, as you said happens with you after a three month period off the Nardil, my doctor is prepared to try me on a small dose of Wellbutrin, esp. because of its Dopaminergic effect. He might also add some Neurontin to prevent seizures that Wellbutrin can cause in some people. I happen to have a hypersensitive nervous system which is why I always seemed to respond on lower doses of medications than most people. I read in the past an authoritative article stating that people who suffer from panic disorder tend to not produce or process DOPAMINE as well as those who don't have the disorder, and that in fact they can later develop Parkinson's Disease because of this. Sorry! I didn't mean to scare you here,
> > ;), but was just trying to share the information I came across through my own research. I also have been reading about some antidepressants and stimulant drugs causing heart damage over time, as my doctors in the hospital tried to tell me, which is another reason I'd like to avoid going back on an antidepressant unless my life depended on it. These are things to keep in mind when considering what medications to replace the Nardil with. Take care.
>
>
Posted by Shyone on June 19, 2010, at 19:03:58
In reply to Re: MAOI replacement options, posted by Murph on June 19, 2010, at 17:36:03
I heard about this triple reuptake inhibitor about 2 years ago and actually mentioned it on the Anxiety Community "Nardil" post.
The only problem is: When is it ever going to come out? Apparently, there are two companies making it, and one is supposed to be released in 2011 and the other in 2012. But who knows if that's true.
I wish they would hurry and hope that it would work as well as "old Nardil" used to, but without the risks of hypertensive crises. And I guess we would have to add something like Xanax or Neurontin to also replace the GABA, the way Nardil does. The other problem is that we'd be the first ones to try it and who knows what would come out later about heart damage, cancer, or God knows what where they'd ban it from the market.
Plus I don't even know in my case if I can be on any antidepressants after the experience I had with my heart -- since they act a lot like stimulants. Maybe a small dose might work for me.
This is the end of the thread.
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