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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 10 of 10. This is the beginning of the thread.
Posted by brooke484 on May 2, 2009, at 18:14:31
Luvox must not agree with me. After only two days on 12.5 mgs I can't take it anymore. I'm not even willing to tough it out. So I'm going back on a low dose of Nefazodone. Just wondering how long I have to wait to start.
Thanks so much,
brooke
Posted by Phillipa on May 2, 2009, at 20:13:04
In reply to Stopped Luvox - how soon can I start Nefazodone?, posted by brooke484 on May 2, 2009, at 18:14:31
Brooke think you start right away since I've been on the luvox for so many years at low low dose what did you find intolerable? Thanks Phillipa
Posted by Phillipa on May 2, 2009, at 20:14:13
In reply to Re: Stopped Luvox - how soon can I start Nefazodone? » brooke484, posted by Phillipa on May 2, 2009, at 20:13:04
Ps I have nefazodone here too full bottle. Phillipa
Posted by Jay_Bravest_Face on May 2, 2009, at 22:09:45
In reply to Stopped Luvox - how soon can I start Nefazodone?, posted by brooke484 on May 2, 2009, at 18:14:31
> Luvox must not agree with me. After only two days on 12.5 mgs I can't take it anymore. I'm not even willing to tough it out. So I'm going back on a low dose of Nefazodone. Just wondering how long I have to wait to start.
>
> Thanks so much,
>
> brookeLuvox has a short half-life, so I'd imagine within a few days would not be a problem. Oh, and I found nefazodone in combination with an SNRI to be excellent. The nefazodone, with it's 5-ht2 blockade, seems to take away the over-stimulation of the SNRI. I REALLY noticed too, it helped with reducing sexual side-effects and insomnia, in combination. Good luck....
Jay
Posted by yxibow on May 3, 2009, at 1:02:36
In reply to Stopped Luvox - how soon can I start Nefazodone?, posted by brooke484 on May 2, 2009, at 18:14:31
> Luvox must not agree with me. After only two days on 12.5 mgs I can't take it anymore. I'm not even willing to tough it out. So I'm going back on a low dose of Nefazodone. Just wondering how long I have to wait to start.
>
> Thanks so much,
>
> brookeAs noted, I doubt you really have to wait at all. SSRIs should be ramped up with reasonable dose intervals like other antidepressants.
MAOIs and a few esoteric drug-drug combinations that are probably lurking there outside of psychiatry are the only ones that you really have to be concerned about.
-- Jay
Posted by yxibow on May 3, 2009, at 1:03:53
In reply to Re: Stopped Luvox - how soon can I start Nefazodone? » brooke484, posted by yxibow on May 3, 2009, at 1:02:36
> > Luvox must not agree with me. After only two days on 12.5 mgs I can't take it anymore. I'm not even willing to tough it out. So I'm going back on a low dose of Nefazodone. Just wondering how long I have to wait to start.
> >
> > Thanks so much,
> >
> > brooke
>
> As noted, I doubt you really have to wait at all. SSRIs should be ramped up with reasonable dose intervals like other antidepressants.
>
> MAOIs and a few esoteric drug-drug combinations that are probably lurking there outside of psychiatry are the only ones that you really have to be concerned about.
>
> -- Jayack -- meant ramped down, switched the order of agents you're switching. answer still the same. :)
Posted by SLS on May 3, 2009, at 7:04:47
In reply to Stopped Luvox - how soon can I start Nefazodone?, posted by brooke484 on May 2, 2009, at 18:14:31
> Luvox must not agree with me. After only two days on 12.5 mgs I can't take it anymore. I'm not even willing to tough it out. So I'm going back on a low dose of Nefazodone. Just wondering how long I have to wait to start.
I would echo what Jay said. That you have so little Luvox in your system shouldn't create a situation that would produce serotonin syndrome. The half-life of Luvox is about 15 hours. Nefazodone will not inhibit or slow down the clearance of Luvox. You can cross over to nefazodone as quickly as you can tolerate any side effects.Luvox: Inhibits CYP4501a2
nefazodone: Inhibits CYP4503a4Neither drug affects the other's metabolism in the liver. They are not competitive substrates for the same enzymes.
- Scott
Posted by brooke484 on May 3, 2009, at 9:08:28
In reply to Re: Stopped Luvox - how soon can I start Nefazodone? » brooke484, posted by Phillipa on May 2, 2009, at 20:13:04
Well the first day wasn't too bad but the second day I felt like I had a major hangover. I spent most of the day in bed. Today I still have a headache and am just tired. I'm also tired of trying these medications that have way too many side effects! When you're as sick as I am anything that makes you worse just isn't worth it.
At least Nefazodone didn't hit me like a truck.
Thanks for your reply,
brooke
Posted by brooke484 on May 3, 2009, at 9:09:19
In reply to Phillipa, posted by brooke484 on May 3, 2009, at 9:08:28
.
Posted by Phillipa on May 3, 2009, at 20:17:26
In reply to Phillipa, posted by brooke484 on May 3, 2009, at 9:08:28
Brooke just strange as the only one I can tolerate. But then I'm wierd!!!! Good luck. Love Phillipa
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