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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 8 of 8. This is the beginning of the thread.
Posted by YOGI BRONX on December 2, 2008, at 23:06:11
Milnacipran is a Selective Norepinephrine & Serotonin Reuptake Inhibitor. Unlike previous drugs, (Effexor & Cymbalta), its ratio of inhibition is 3 to 1, norepinephrine to serotonin. Those drugs ratios were 33 to 1, serotonin to norepinephrine.
I d.c.'d it after one day because of terrible ischuria after the 2nd daily dose of a 25 mg. tablet
I would appreciate feedback from anyone who is taking or has taken this medication.
Thanks.
Posted by Phillipa on December 3, 2008, at 12:42:29
In reply to Ixel (Milnacipran), posted by YOGI BRONX on December 2, 2008, at 23:06:11
Urinary retention right? I'm sorry but that is a horrible feeling. Love Phillipa
Posted by YOGI BRONX on December 3, 2008, at 12:53:41
In reply to Re: Ixel (Milnacipran) » YOGI BRONX, posted by Phillipa on December 3, 2008, at 12:42:29
Dear Phillipa,
Thanks for the commiseration. Yes, a horrible feeling indeed. Galling to me, especially, since only 2.7% of patients have this side effect and I virtually never have physical side effects from psych meds.
Cordially,
YOGI
Posted by Sigismund on December 3, 2008, at 15:38:46
In reply to Ixel (Milnacipran), posted by YOGI BRONX on December 2, 2008, at 23:06:11
It is an interesting drug with some good aspects, but the NE effect was too strong for me.
I could imagine taking a total of 12.5mg/d in divided doses.
Otherwise I get this awful feeling, kinda like ants under my skin.
Posted by bleauberry on December 4, 2008, at 18:09:36
In reply to Ixel (Milnacipran), posted by YOGI BRONX on December 2, 2008, at 23:06:11
I think the documented doses are just sometimes too high. I saw a case report where 15mg eliminated a woman's depression. Me, a mere 18mg had me lifting out of the pits in about 10 days, actually beginning the second day.
For urinary side effects, the prostate med Flomax (Tumsulosin), works like a charm. It comes in 2mg and 4mg sizes, but I found taking half a capsule was just fine. Other side effects can be tough to handle, but users say they go away in about a month.
You can get empty gel caps, divide up the milnacipran powder into fairly equal piles of custom sized doses, reload them into your gel caps, and make your own doses. The best for me was 6mg 3 times per day.
It is the best med I've ever tried since ECT failed. That says a lot. Any med that can show promise after ECT failure has got to be a good med.
Just go slow and low. Forget the dosing instructions. Do your own.
Posted by YOGI BRONX on December 4, 2008, at 19:57:26
In reply to Re: Ixel (Milnacipran) » YOGI BRONX, posted by bleauberry on December 4, 2008, at 18:09:36
Dear bleauberry,
Thanks for the response. That's just the kind of personal user information that I was hoping to get.
When I restart, I will follow your lead. I think that I even may have some empty gel caps in stock.
Thanks again from me and my refractory depressive friends who have high hopes for this med.
I will post my experience as soon as I have something worth reporting.
Cordially,
YOGI> I think the documented doses are just sometimes too high. I saw a case report where 15mg eliminated a woman's depression. Me, a mere 18mg had me lifting out of the pits in about 10 days, actually beginning the second day.
>
> For urinary side effects, the prostate med Flomax (Tumsulosin), works like a charm. It comes in 2mg and 4mg sizes, but I found taking half a capsule was just fine. Other side effects can be tough to handle, but users say they go away in about a month.
>
> You can get empty gel caps, divide up the milnacipran powder into fairly equal piles of custom sized doses, reload them into your gel caps, and make your own doses. The best for me was 6mg 3 times per day.
>
> It is the best med I've ever tried since ECT failed. That says a lot. Any med that can show promise after ECT failure has got to be a good med.
>
> Just go slow and low. Forget the dosing instructions. Do your own.
Posted by bleauberry on December 5, 2008, at 15:34:07
In reply to Re: Ixel (Milnacipran) » bleauberry, posted by YOGI BRONX on December 4, 2008, at 19:57:26
Best wishes for you. Don't forget, you are awesome!
Ya know, just like any other meds, people here have tried milnacipran and not stayed with it. But, I do not recall anyone who did not stay with it due to ineffectiveness. As best I can recall, the few who did not stay with it had problems with either nausea or urinary. Those who did stay with it, well, they don't hang out here anymore. That usually means they got better and are out enjoying a new life. Except for a few veterans who stay here to help others, most people who get well are glad to forget about needing pbabble.
One of the last ones I remember was ATM Lady. She was doing well but worried Milnacipran wouldn't hold her through the tough winter months. So far she is still not back here, so I assume it is still holding well.
> Dear bleauberry,
>
> Thanks for the response. That's just the kind of personal user information that I was hoping to get.
>
> When I restart, I will follow your lead. I think that I even may have some empty gel caps in stock.
>
> Thanks again from me and my refractory depressive friends who have high hopes for this med.
>
> I will post my experience as soon as I have something worth reporting.
>
> Cordially,
> YOGI
>
> > I think the documented doses are just sometimes too high. I saw a case report where 15mg eliminated a woman's depression. Me, a mere 18mg had me lifting out of the pits in about 10 days, actually beginning the second day.
> >
> > For urinary side effects, the prostate med Flomax (Tumsulosin), works like a charm. It comes in 2mg and 4mg sizes, but I found taking half a capsule was just fine. Other side effects can be tough to handle, but users say they go away in about a month.
> >
> > You can get empty gel caps, divide up the milnacipran powder into fairly equal piles of custom sized doses, reload them into your gel caps, and make your own doses. The best for me was 6mg 3 times per day.
> >
> > It is the best med I've ever tried since ECT failed. That says a lot. Any med that can show promise after ECT failure has got to be a good med.
> >
> > Just go slow and low. Forget the dosing instructions. Do your own.
>
>
Posted by YOGI BRONX on December 6, 2008, at 14:29:11
In reply to Re: Ixel (Milnacipran) » YOGI BRONX, posted by bleauberry on December 4, 2008, at 18:09:36
Dear bleauberry,
Thanks again for the useful information. I have a follow-up question.
You said that you divide the original capsules into 6 mg. doses. I assume that you start out with the manufactured 25 mg. capsules, break them open, and divide the contents by 4, permitting the 1 mg. excess to be divided by chance.
How do you manage to get 6 mg. capsules?
I have done some web research and found that one can purchase inexpensive machines to make numerous capsules at one time. However, I cannot figure out how to divide the original capsule evenly.
For instance, I can bulk out the original contents with an inert filler, but how do I know how much filler to add to fill just exactly, and no more than 24 or 48 or 144 capsules so that each capsule receives exactly 6 mg.
Rather than illustrating the methods that I have figured out don't work, can you tell me how you do it?
Oh, one way I have figured out that WILL work is a balance-beam. But that would be awfully slow and expensive.
Thanks.
Cordially,
YOGI
This is the end of the thread.
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