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Dr. Bob is Robert Hsiung, MD,
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Posted by Maria3667 on November 4, 2008, at 11:03:20
Interesting article about anxiety and immune system. Maria.
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In the first study ever to genetically link the immune system to normal behavior, scientists at Rockefeller and Columbia universities show that mast cells, known as the pharmacologic bombshells of the immune system, directly influence how mice respond to stressful situations. The work, to appear this week in the Proceedings of the National Academy of Sciences and to be highlighted in Science, chips away at the increasingly stale idea that the two most complex systems in the body have entirely separate modes of operation.
Eight years ago, scientists from Columbia University discovered that mast cells travel to the brain from other organs early on in development. "We now knew that mast cells resided in the brain but we didn't know their function," says Rockefeller University's Donald Pfaff, head of the Laboratory of Neurobiology and Behavior. "But we know that they synthesize a large number of important chemical mediators that could potentially have severe neurophysiological effects."
Since then, mast cells have been associated with several behaviors and conditions. For example, the number of mast cells and anxiety levels in mice have been shown to ebb and flow with the onset of stressful conditions, including asthma and food allergies. Lethargy has also been associated with an excess of mast cells. "However, we have now been the first to manipulate mast cells genetically and pharmacologically and show an immediate behavioral effect," says Pfaff.
In their work, Pfaff and postdoc Ana Ribeiro, and the Columbia team, led by senior author Rae Silver and graduate student Kate Nautiyal, bred mice that lacked mast cells and compared their behavior in stressful situations to the behavior of mice that had a full or a moderate arsenal of mast cells. The researchers observed how willing the mice were to navigate open and lit environments and high spaces, which mice find anxiety-producing. In the wild, if a mouse is down in its own burrow, it's not visible to predation. But if it's bold, that is, if it has low anxiety, it will go out where it can potentially be seen by predators and hunted.
The results were striking. When the researchers placed the mice in an elevated maze with four long arms -- two simulated a canyon and the other two a cliff -- mice that lacked mast cells preferred to stay in the canyons, entering and investigating the doors to the cliffs significantly fewer times than mice with mast cells. When placed in a square box, mast cell-deficient mice preferred to scuttle against the walls, and were more hesitant to venture out to the center of the box than mice with mast cells. They also defecated more, a physiological sign of anxiety. However, the genetically different mice did not show differences in overall arousal or locomotion, suggesting that their behavioral changes were specific to their anxious state.
To confirm the behavioral and physiological differences among the genetically different mice, the researchers conducted an additional experiment. In mice that had mast cells, they used a drug that prevents sack-like granules in mast cells from busting open and releasing the array of mood and immune regulators they contain, such as serotonin, histamine, and various biochemical mediators. When the researchers targeted the drug to work specifically on mast cells in the brain, rather than in other organs, the mice showed much higher levels of anxiety-like behavior during the tests, but showed no difference in other tested physiological responses.
"The two most complicated and highly integrated systems in the body - the immune system and the nervous system - have been shown to be linked," says Pfaff. "We now show that mast cells in the brain link these two systems at the level of behavior."
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Article adapted by Medical News Today from original press release.
----------------------------Source: Thania Benios
Rockefeller University
Posted by Phillipa on November 4, 2008, at 12:26:11
In reply to Anxiety And Immune System Linked In Mouse Model, posted by Maria3667 on November 4, 2008, at 11:03:20
Heres a definition of mast cells seem to be associated with allergies and severe autoimmune diseases. Phillipa
Posted by Maria3667 on November 4, 2008, at 13:08:21
In reply to Re: Mast Cells » Maria3667, posted by Phillipa on November 4, 2008, at 12:26:11
Hi Phillipa,
Could this explain why I have such high anxiety?
Five years ago I was diagnosed with an auto-immune disease (Sjogren's syndrome) and ever since I've been battling out of control anxiety.
I even went up to 900 mgs of Seroquel to no avail. I also take loads of supplements like magnesium, fish oil, niacine and others.
So you've heard of this theory before?
Love,
Maria
Posted by Phillipa on November 4, 2008, at 19:45:28
In reply to Re: Mast Cells » Phillipa, posted by Maria3667 on November 4, 2008, at 13:08:21
Maria no I haven't but at one time they thought I had Sjornes so will do some more digging. Love Phillipa
Posted by Phillipa on November 4, 2008, at 19:53:41
In reply to Re: Mast Cells » Maria3667, posted by Phillipa on November 4, 2008, at 19:45:28
Maria another link and does mention thyroid so if thyroid hyper anxiety. Phillipa
Posted by Extreme on November 5, 2008, at 8:37:28
In reply to Re: Mast Cells, posted by Phillipa on November 4, 2008, at 19:53:41
Very interesting.
In irritable bowel syndrome (IBS) which I have there is evidence of increased mast-cells in the guts. People with IBS often suffer from more anxiety in general than healthy persons. Would be very intersting to find out if mast-cells are increased in the brain due to this or if local mast-cells in the gut signals "high alert" and that signal makes the brain volnurable to anxiety + of course making the invoncience of having a ***** up stomach worse.
Posted by Maria3667 on November 5, 2008, at 11:11:13
In reply to Re: Mast Cells, posted by Phillipa on November 4, 2008, at 19:53:41
Hi Philippa,
Well it's quite the opposite actually: I am hypothyroid (but this can also cause anxiety).
Thanks,
Maria
Posted by Phillipa on November 5, 2008, at 19:08:23
In reply to Re: Mast Cells » Phillipa, posted by Maria3667 on November 5, 2008, at 11:11:13
Oh I know as I am also and had TSH of 22 and was hospitalized as jumping out of my skin. Now it's below l and still anxiety but tiredness also. Phillipa
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