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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 23 of 23. This is the beginning of the thread.
Posted by tepi on September 14, 2008, at 4:44:14
Has anybody hear news about new promising meds??
Any new kind of MAOI ? Psychotic? anxiey??
Posted by Phillipa on September 14, 2008, at 12:19:49
In reply to New meds to come?, posted by tepi on September 14, 2008, at 4:44:14
Tepi you're back!!!! How are you? Love Phillipa
Posted by Jeroen on September 14, 2008, at 14:16:48
In reply to Re: New meds to come? » tepi, posted by Phillipa on September 14, 2008, at 12:19:49
yea psychotic meds, thats what this world needs
Posted by dbc on September 15, 2008, at 17:52:40
In reply to Re: New meds to come?, posted by Jeroen on September 14, 2008, at 14:16:48
Glutamate based anti-psychotics will be on the way in the next couple years.
Posted by tepi on September 15, 2008, at 22:55:02
In reply to Re: New meds to come?, posted by dbc on September 15, 2008, at 17:52:40
Seems the meds are getting out very slow as always.
A doc suggested me unitary perception ,
dont know if this works , it may sounds unknow for you , it is suppose to be a new tecnhique of
psychological treatment I think.Need a Doc , I want to add more things to Nardil
damn social fear dont leave me , this is hell
though many people think its a peace of cake it simply destroys your entire life
Posted by JayBTV2 on September 16, 2008, at 13:36:04
In reply to Re: New meds to come?, posted by tepi on September 15, 2008, at 22:55:02
Agomelatine (Valdoxan) is the best hope we have coming down the pike. Hopefully will be available next year in Europe and if so hopefully in the US by 2010.
It's a novel antidepressant which works on the Melatonin receptors as long as slightly w/ Serotonin.
Latest study w/ Valdoxan:
Posted by yxibow on September 20, 2008, at 0:53:04
In reply to Re: New meds to come?, posted by JayBTV2 on September 16, 2008, at 13:36:04
> Agomelatine (Valdoxan) is the best hope we have coming down the pike. Hopefully will be available next year in Europe and if so hopefully in the US by 2010.
>
> It's a novel antidepressant which works on the Melatonin receptors as long as slightly w/ Serotonin.
>
> Latest study w/ Valdoxan:
>
> http://www.pslgroup.com/dg/22a766.htm
>This would be interesting but Servier largely is bypassed in the US. They mainly have a profile of agents approved in France and EMEA. I don't know if its politics or a lack of rechallenging FDA findings.
Posted by Marty on September 21, 2008, at 15:20:53
In reply to Re: New meds to come?, posted by JayBTV2 on September 16, 2008, at 13:36:04
> Agomelatine (Valdoxan) is the best hope we have coming down the pike.
---
While it's the one I'm also waiting for, I wonder why you say it's the best hope 'we' (everybody) have.
> It's a novel antidepressant which works on the Melatonin receptors as long as slightly w/ Serotonin.
---
Its 5-HT2c antagonistic properties seems to be more than 'lite' and while 5-HT2c is a serotonin receptor, the effect of the antagonism is mainly related to dopamine if I remember well./\/\arty
Posted by Marty on September 21, 2008, at 15:22:12
In reply to New meds to come?, posted by tepi on September 14, 2008, at 4:44:14
> Has anybody hear news about new promising meds??
> Any new kind of MAOI ? Psychotic? anxiey??
---
Hi Tepi, I think a very good source for that kind of info is at http://www.neurotransmitter.net/newdrugs.html/\/\arty
Posted by desolationrower on September 21, 2008, at 17:08:08
In reply to Re: New meds to come? » JayBTV2, posted by Marty on September 21, 2008, at 15:20:53
5ht2c also greatly improves slow-wave sleep. It should be a great drug for sleep with few side effects.
The one side effect i worry about is weight gain. antagonising 5ht2c is speculated to be part of the reason olanzapine and clozapine cause so much weight gain, mirtazapine make people eat constantly, and cyproheptadine is used to help people gain weight. There are other drugs which don't match this though.
So i'm curious: anyone who has taken agomelatine, how did it affect your weight or appetite?
-D/R
Posted by Marty on September 21, 2008, at 17:19:23
In reply to agomelatine and hunger/weight, posted by desolationrower on September 21, 2008, at 17:08:08
> 5ht2c also greatly improves slow-wave sleep.
---
Antagonism, yes, but it also is stimulating and so it should be less effective than Ramelteon regarding sleep.> The one side effect i worry about is weight gain. antagonising 5ht2c is speculated to be part of the reason olanzapine and clozapine cause so much weight gain, mirtazapine make people eat constantly, and cyproheptadine is used to help people gain weight. There are other drugs which don't match this though.
---
I thought it was 5-HT2a antagonism and also Histaminergic properties that made those drug weight-inducing. If you're right than I too is concerned by that aspect.../\/\arty
Posted by desolationrower on September 21, 2008, at 17:34:54
In reply to Re: agomelatine and hunger/weight » desolationrower, posted by Marty on September 21, 2008, at 17:19:23
I am not aware of a link with serotonin 2A. I agree histamine ant. can be weight gain inducings, as can dopamine antagonism. The antispychotics have a couple of mechanisms that all work together to make weight gain almost inevitable.
But some 5ht2c don't seem to: flouoxetine, ziprasidone. Thats why I'm curious about some first hand experiences, i don't remember anything in the published studies.
-D/R
Posted by Phillipa on September 21, 2008, at 19:18:13
In reply to Re: New meds to come? » tepi, posted by Marty on September 21, 2008, at 15:22:12
Marty you do know that Shawn and JR Becker post on babble? Love Phillipa
Posted by clipper40 on September 22, 2008, at 1:31:50
In reply to Re: agomelatine and hunger/weight, posted by desolationrower on September 21, 2008, at 17:34:54
I did a google search on agomelatine + weight. All of the articles I read said it was weight neutral. Here's one of them:
http://biopsychiatry.com/agomelatine-valdoxan.html
Fingers crossed that this is all true.
Posted by Marty on September 22, 2008, at 12:13:00
In reply to Re: New meds to come? » Marty, posted by Phillipa on September 21, 2008, at 19:18:13
> Marty you do know that Shawn and JR Becker post on babble? Love Phillipa
---Hi Phil,
I don't know Shawn and JR Becker and so I don't even know why I should be aware of them posting on babble :P Please tell me... you got me curious
/\/\arty
Posted by Marty on September 22, 2008, at 12:29:28
In reply to Re: agomelatine and hunger/weight, posted by desolationrower on September 21, 2008, at 17:34:54
> I am not aware of a link with serotonin 2A.
---
My mistake. My memory lately isn't top shape. I sometime wonder if those meds I take doesn't want me to know too much about them and voluntary mess with the neurons cluster responsible for memorizing those 5-HT2(x) characteristics ;)You're right: 5-HT2c is strongly linked with control of appetite, satiety, carbohydrate craving and the (neuro)hormone Leptin. I hope, like you, that Agomelatine is more of a Fluoxetine than a Cyproheptadine.
/\/\arty
Posted by Phillipa on September 22, 2008, at 20:28:12
In reply to Re: New meds to come? » Phillipa, posted by Marty on September 22, 2008, at 12:13:00
Marty check neurotransmitters when first started as Shawn posted there and JR Becker posts a lot of studies on this board one pretty recently. Love Phillipa
Posted by JayBTV2 on September 23, 2008, at 10:48:22
In reply to Re: New meds to come? » JayBTV2, posted by Marty on September 21, 2008, at 15:20:53
>
> > Agomelatine (Valdoxan) is the best hope we have coming down the pike.
> ---
> While it's the one I'm also waiting for, I wonder why you say it's the best hope 'we' (everybody) have.
>As far as new meds that look promising for mental illnesses (Depression / Anxiety in this case).
I didn't mean to say we all have the same issues - I apologize if that's how it read.
Check the below link for other meds (all classes) that are in the pipeline....
Posted by rotem on September 23, 2008, at 12:50:30
In reply to agomelatine and hunger/weight, posted by desolationrower on September 21, 2008, at 17:08:08
I'm also looking forward yearningly for Agomelatine to be marketed.
not only it's greatly improves slow-wave sleep,
which is too low in depression.
It also doesn't decrease libido.here's a link
http://www.ncbi.nlm.nih.gov/pubmed/18801825?dopt=AbstractPlus
Posted by rotem on September 23, 2008, at 17:40:42
In reply to Re: agomelatine and hunger/weight, posted by rotem on September 23, 2008, at 12:50:30
can we do something to hurry it's marketing?
I can't wait.http://www.ncbi.nlm.nih.gov/pubmed/18801825?dopt=AbstractPlus
Posted by Marty on September 23, 2008, at 18:44:01
In reply to agomelatine doesn't cause sexual dysfunction, posted by rotem on September 23, 2008, at 17:40:42
> can we do something to hurry it's marketing?
> I can't wait.
---
Funny you ask. I asked myself the same question. A petition (with signatures in the thousands.. ~2000?) and a clever open letter endorsed by one or two Psychiatrists (preferably 1 from Europe(France) and 1 from USA) that we would try to get published in the best medical journal we could .. that could be helpful to Servier/Novartis.I think it's feasable. The main point of the open letter to the EMEA/FDA could be the need for more atypical antidepressants for treatment resistant people. The EMEA/FDA wants to approve meds that are proven superior to the one already on the market and that's a bad thing for treatment resistant / treatment intolerant people. I don't care if an -ATYPICAL- AD works only for 20% of the people since those AREN'T marketed as first line treatment. What's count is to have as much as different ADs with different mechanism of action that we can! .... that said, Agomelatine has been proven superior to Paroxetine and Sertraline in a couple of trials but doubts will remain as long as Servier doesn't finance more trials. My opinion ? Agomelatine is pretty safe and the EMEA/FDA shouldn't care much about more trials to confirm superiority of it: Even if it works on 2 time LESS people than Paroxetine or Sertraline IT DOESN'T MATTER SINCE IT'S A NEW CLASS OF ATYPICAL ANTIDEPRESSANT. People are waiting in suffering for those atypicals.. could they wait for the next in the SAME CLASS before bitching about superiority ?
/\/\arty
Posted by rotem on September 23, 2008, at 19:10:44
In reply to Re: agomelatine doesn't cause sexual dysfunction » rotem, posted by Marty on September 23, 2008, at 18:44:01
you phrased it excellently. I agree with every word you wrote.
Posted by Marty on September 25, 2008, at 11:07:17
In reply to Re: agomelatine doesn't cause sexual dysfunction, posted by rotem on September 23, 2008, at 19:10:44
I've created a new thread with the infos:http://www.dr-bob.org/babble/20080915/msgs/853983.html
/\/\arty
This is the end of the thread.
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