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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 12 to 36 of 36. Go back in thread:
Posted by Marty on September 1, 2008, at 15:25:53
In reply to Getting back on Agomelatine (Valdoxon), posted by subconscious101 on August 31, 2008, at 21:50:17
subconscious101,If Agomelatine is marketted in Europe in the next couple months (rumored to be possibly THIS MONTH) .. would you be able to afford some ? I, for one, plan to order it ASAP.
/\/\arty
Posted by subconscious101 on September 1, 2008, at 15:28:32
In reply to Re: Getting back on Agomelatine (Valdoxon) » subconscious101, posted by Marty on September 1, 2008, at 15:25:53
Where did you hear that information because alot of people say things on here and have nothing to back them up?? Yes of course i would be able to afford it i would fly there if i had to. Like i said i would give up everything that i have to get back on it.
Posted by Marty on September 1, 2008, at 15:34:14
In reply to Re: Getting back on Agomelatine (Valdoxon), posted by subconscious101 on September 1, 2008, at 15:23:51
> You guys i have tried most of these medications and believe me they are nothing like agomelatine. Agomelatine can not be duplicated!
---
Again, you just increased my hope in this drug. That said, maybe not emulated.. but duplicated/synthesized it could. Emulation is quite difficult or impossible just by mixing drugs sharing some properties with Agomelatine and that's mainly because it's never just a question of 'What does it do ?' but also a question of 'WHERE DOES IT DO IT ?'. By example: 5-HT2c antagonism .. but is it everywhere in the brain or more specifically in one/some region ? This changes a lot of things. Anyway .. Like someone on this thread mentionned previously about duplicating (Synthesizing/Producing) Agomelatine: you would need thousands of dollars just to get a chemist find a way to produce some.. and them charge you about a couple hundred per month for your 30 pills./\/\arty
Posted by Marty on September 1, 2008, at 15:43:03
In reply to Re: Getting back on Agomelatine (Valdoxon), posted by subconscious101 on September 1, 2008, at 15:28:32
> Where did you hear that information because alot of people say things on here and have nothing to back them up?? Yes of course i would be able to afford it i would fly there if i had to. Like i said i would give up everything that i have to get back on it.
---Don't want to give you false hope, but I read that here on pbabble (on a thread you were on also) and *I THINK* saw something on the web about this rumor also... I cross my finger that it's for real. Search the thread I talk about, I think you were the one starting it a couple weeks/months ago... there you'll find the other guy who seems to know the source of this rumor. I think I remember seeing this rumor mentionned in a PDF/PowerPoint in russian a couple weeks ago and an other place I can't remember for now.
/\/\arty
Posted by Marty on September 1, 2008, at 17:07:53
In reply to Re: Getting back on Agomelatine (Valdoxon), posted by subconscious101 on September 1, 2008, at 15:28:32
BTW Subconscious, do you know 'Google Alerts' service ? It's free and you may want to use it to track what's news about Agomelatine. You simply give Google Alerts the keyword 'Agomelatine' and your email adresse. That's it.. when Google detects some new web pages/document mentioning Agomelatine, it sends you an Email ... you can ask updates every time there's something new or a report every week, month etc...
That's how I found out about THIS THREAD you just created ! Google sent me an email with the URL of the thread ...
Enjoy,
/\/\arty
Posted by Nadezda on September 2, 2008, at 10:23:05
In reply to Getting back on Agomelatine (Valdoxon), posted by subconscious101 on August 31, 2008, at 21:50:17
Someone posted this on Wiki Answers:
~~ Agomelatine is currently being re-examined by the EMEA , after a previous failed attempt by Servier to gain approval in 2006. The concern at the time was that effiicacy for long term treatment of depression had not been demonstated. Recent studies have shown agomelatine is effective in long term treatment of depression and useful in anxiety disorders. The EMEA result is expected in mid 2008, so the drug may be available in europe in 2009 if there are no problems.
In the USA Novartis has the rights to develop Agomelatine and it is currently in phase III trials, submission to the FDA may occur by the end of 2008. If all goes well I guess end of 2009/2010 for release in the US is likely. ~~It's almost impossible to find anything about agomelatine on the Novartis or Servier sites, which is strange. But there are five clinical trials, all not recruiting, all scheduled to be completed in the 2009, one of t hem not until October. Sounds like agomelatine won't be available until at least 2010.
Where did your pdoc call? Maybe if he called people at the different clinical trials, someone would be able to help. The locations are listed on the Novartis R&D site (you go to a US gov site, I think).
Wish I could think of something better.
Nadezda
Posted by Marty on September 2, 2008, at 10:44:21
In reply to Re: Getting back on Agomelatine (Valdoxon) » subconscious101, posted by Nadezda on September 2, 2008, at 10:23:05
Nadezda,
> But there are five clinical trials, all not recruiting, all scheduled to be completed in the 2009, one of t hem not until October. Sounds like agomelatine won't be available until at least 2010.
---I don't think the 2009 scheduled clinical trials are significative regarding the marketting date of Agomelatine. There will be many clinical trials on this drug, non stop, for many years if it were to be marketed: seeking approval for other disorders, strengthening the reputation of the drug and creating a buzz with good trial results etc. Even if the EMEA approve AGO in 2008, Servier needs to generate other good trial results to compensate for some that were not very good in order to make it clear in the mind of the practicians: there's a world of difference between "AGO -IS- working.. 8 out of 11 trials proved it" .. Versus .. "4 out of 7 trials proved it". Also those clinical trials in 2009 could be a 'Plan C' for Servier if the EMEA doesn't approve AGO in 2008... to prepare themself for a 3rd submission to the EMEA.
I still think we could se AGO marketed in Europe between this month and Febuary 2009.
BTW, Have you tried Agomelatine Nadezda ?
/\/\arty
Posted by Nadezda on September 2, 2008, at 13:40:58
In reply to Re: Getting back on Agomelatine (Valdoxon) » Nadezda, posted by Marty on September 2, 2008, at 10:44:21
I haven't tried it. But from what I've read after this thread started, I'd be very interested in doing so.
I'm not sure what I think about melatonin agonists-- rozerem doesn't do a lot for me. But I have severe issues with sleep, which of course contributes to a lot of stress and moodiness and bad days.
The studies I cited were US studies, by the way-- so I think they were meant for the US market. Was the problem bad results, or just not a long-term enough trial, in Europe? I had understood from what I saw that it was more that the Servier studies were short term, and the Europeans wanted evidence of long-term efficacy (and probably safety). You're right to be a little more pessimistic about getting anything to market here-- it often takes much longer than initially announced. Really beyond frustrating.
What are you using now?
Nadezda
Posted by subconscious101 on September 2, 2008, at 15:40:27
In reply to Getting back on Agomelatine (Valdoxon), posted by subconscious101 on August 31, 2008, at 21:50:17
I was just wondering if anyone knows of an antidepressent that doesent generly tend to make people feel more anxious and parinoid . I am so sick and tierd of trying ADs that make me feel that way. It seems everything that i have tried so far makes me feel more anxious and parinoid. Even agomelatine did abit but the benafits where much much greater and it was much less than some other AD i have tried. Any suggestions ?? Welbutrian works great for me as an AD but even at 150 mg the smallest dose makes me feel realy anxious and paranoid.
Posted by Marty on September 2, 2008, at 18:33:23
In reply to Re: Getting back on Agomelatine (Valdoxon) » Marty, posted by Nadezda on September 2, 2008, at 13:40:58
Agomelatine is better than ZoloftCheck this out (the link in my new post).. It's making 'medical' news TODAY ..
Posted by Marty on September 2, 2008, at 18:40:04
In reply to Re: Getting back on Agomelatine (Valdoxon), posted by subconscious101 on September 2, 2008, at 15:40:27
I was wondering if Dr.Kasper was respected enough to influence the EMEA to approve Agomelatine: Well guess what ?
"Dr.Kasper ...is also an adviser to the European Agency for the Evaluation of Medicinal Products (EMEA)."
This isn't good news.. this is VERY good news.
Source: http://www.litebook.com/support/skasper.asp
/\/\arty
Posted by Nadezda on September 2, 2008, at 20:51:11
In reply to Re: Getting back on Agomelatine (Valdoxon), posted by Marty on September 2, 2008, at 18:40:04
That's a great find, Marty.
I know my pdoc doesn't really trust European studies-- at least, he wasn't willing to try Milnacipran based on the use of Ixel. (Maybe he had other reasons, too, I don't know.) But this sounds like extremely promising evidence-- and if it holds up here, could be really great.
I probably wouldn't try it without his involvement, but I'd be very interested in knowing what happens, and-- if and when it's released in Europe-- how people are doing with it. I'll also ask my pdoc about it the next time I see him.
Let's hope it progresses as this study suggests.
Nadezda
Posted by Negcreep on September 3, 2008, at 9:44:20
In reply to Re: Getting back on Agomelatine--great news! » Marty, posted by Nadezda on September 2, 2008, at 20:51:11
Hey guys, seems like the forum is once again buzzing with talk of AGO. The new articles saying that its better than Zoloft are great as well. Just so you know, I wrote the wiki answers and half the wikipedia entry on AGO, using all the stuff I've read online. I think I referenced most of it on wikipedia, so its all good.
Subconcious....I think you are pretty much screwed untill agomelatine is released somewhere in the world. Saying that...I have seen those chinese chemist websites someone mentioned. They do indeed seem to offer drugs/chemicals for ridiculous prices. Even if you did mangage to pick some up however, what assurrances do you have that its even the real deal? Or that its safe for human consumption!?
Id bet that while you havent really found any other drug that works for you that there must have been something you have tried that at least helped a bit. Go back on one of those and cope best you can in the mean time its all you can do.Try combinations as well.I keep checking the EMEA website for news of AGO. They release monthly reports on drugs approved in the first week of every month.
Neg
Posted by Marty on September 3, 2008, at 14:29:58
In reply to Re: Getting back on Agomelatine--great news!, posted by Negcreep on September 3, 2008, at 9:44:20
Neg,
Just to be 100% sure: Do you know 'Google Alerts' service ? If not I suggest you too setup yourself an alert for the term 'Agomelatine' and 'Valdoxan' .. whatever something appears on the web about those terms Google sends you an email with the links. Usually it takes about ~5 hours MAX. It even catch up any new thread/post related to AGOM on pbabble .. So we wont miss anything.
/\/\arty
Posted by Negcreep on September 4, 2008, at 9:39:51
In reply to Re: Getting back on Agomelatine--great news! » Negcreep, posted by Marty on September 3, 2008, at 14:29:58
Ah thanks Marty, ive just signed up to it :)
Neg
Posted by Extreme on September 11, 2008, at 16:45:24
In reply to Re: Getting back on Agomelatine--great news! » Negcreep, posted by Marty on September 3, 2008, at 14:29:58
Great news! I live in Sweden so I would really like this medication to get approved... I have been waiting for this one several years since I tried natural melatonin around year 2003 and found that it temporarily wiped out 2 diseases that I have, IBS and fibromyalgi (add to that life-long problems with relaxation)... and of course when those were gone my depression from those didnt have a reason to exist. I got immune to melatonin fast and since then I have been looking for medications that manipulate melatonin-receptors. Havnt been able to get hold on Rozerem as its not approved here in Europe.
Lets hope that finally this interesting medication gets approved!
Posted by Negcreep on September 17, 2008, at 7:28:51
In reply to Re: Getting back on Agomelatine--great news!, posted by Extreme on September 11, 2008, at 16:45:24
Heres a link I just found for a brand new research paper:
http://www.psychopharmacology.com/pt/re/jclnpsychopharm/abstract.00004714-200810000-00015.htm;jsessionid=LQ2c8TnZVnyBYGM0Jm15yn19myLM884cPDRKQfDHhq7SF8ngvpsW!-2013963969!181195629!8091!-1
(dont ask me why it cut and past like that)Yeah so great news for people who suffer with GAD (me)as well as those with MDD. I've probably said this a million times but I'm so straight on this drug as soon as its out.
Been checking the EMEA website for a press release from their august meeting but its still not out yet....Its late, perhaps theres some good news to come in it. Can only hope.
Posted by Marty on September 23, 2008, at 12:33:03
In reply to Re: More Great news!, posted by Negcreep on September 17, 2008, at 7:28:51
New published paper (Sept 18) about Agomelatine vs Paroxetine -FOR SEX- .. If I interpret that well, more Agomelatine = less SD. At 50 mg the SD rate falls UNDER baseline (placebo) which means it's pretty much sex neutral ? Does the improvement at higher dose means that Agomelatine improve sex by lowering the depression symptoms ?
Not sure because it doesn't exclude non-responders and so Agomelatine could sexually help even some non-responders, making it (very) slightly pro-sexual. Is that ackward for a serotonergic drug ? No. Because 5-HT2c antagonism has a positive effect on dopaminergic (pro-dopaminergic transmission). It enhances the levels of dopamine and noradrenaline in frontal cortex, for example. (btw, that means it should also be pro-motivation)/\/\arty
Posted by Marty on September 25, 2008, at 11:08:47
In reply to ANOTHER good news!, posted by Marty on September 23, 2008, at 12:33:03
I've created a new thread with all the info !
http://www.dr-bob.org/babble/20080915/msgs/853983.html
/\/\arty
Posted by Extreme on September 28, 2008, at 15:48:22
In reply to ANOTHER good news!, posted by Marty on September 23, 2008, at 12:33:03
They are too slow! :P
Checked the EMEA-site and found many new approved substances.... but no agomelatine!! This is too much! Looks like "Extreme" is headed for... president of the EMEA!!! "Never before in the history of mankind has there been so many good medicines available in SO short time!" :)
Posted by Marty on September 28, 2008, at 18:59:54
In reply to Re: ANOTHER good news!, posted by Extreme on September 28, 2008, at 15:48:22
> They are too slow! :P
>
---
Btw Extreme.. just to be sure to saw my last post: Agomelatine is approved in Ukraine since 2007. I guess it would be easier for you to go live in Ukraine than to apply for EMEA presidency ;)/\/\arty
Posted by Extreme on September 29, 2008, at 8:13:19
In reply to Re: ANOTHER good news! » Extreme, posted by Marty on September 28, 2008, at 18:59:54
> Btw Extreme.. just to be sure to saw my last post: Agomelatine is approved in Ukraine since 2007. I guess it would be easier for you to go live in Ukraine than to apply for EMEA presidency ;)
>
> /\/\artyYes, I saw that, Marty. They work fast over there! Yea.. would be easier I guess BUT I've always aimed high :)
Posted by Extreme on September 29, 2008, at 8:49:51
In reply to Re: ANOTHER good news!, posted by Extreme on September 29, 2008, at 8:13:19
http://www.expressen.se/halsa/1.1315599/mirakelpiller-botar-din-host-depression
The article is in Swedish, its a about a long-time study of SAD (Seasonal affective disorder ) and agomelatine (with very good results.. although the Swedish crap-news never publishes how many involved in the study and stuff like that). The important stuff is this.. the Swedish product manager for Servier says that he believes agomelatine will be here in Sweden in a couple of months perhaps in February. That must mean that an approval is close and that it definitly will be approved! Anyway... president of the EMEA.. my future job... :O :P :)
Posted by Negcreep on September 29, 2008, at 9:45:28
In reply to Close to approval according to swedish source!, posted by Extreme on September 29, 2008, at 8:49:51
Good news, but sucks that its still about 5 months from availability in the EU. I spose in the grand scheme of things its not that long to wait but I sure would like to try it sooner. If theres a will theres a way....
Neg
> http://www.expressen.se/halsa/1.1315599/mirakelpiller-botar-din-host-depression
>
> The article is in Swedish, its a about a long-time study of SAD (Seasonal affective disorder ) and agomelatine (with very good results.. although the Swedish crap-news never publishes how many involved in the study and stuff like that). The important stuff is this.. the Swedish product manager for Servier says that he believes agomelatine will be here in Sweden in a couple of months perhaps in February. That must mean that an approval is close and that it definitly will be approved! Anyway... president of the EMEA.. my future job... :O :P :)
Posted by idork on December 19, 2008, at 5:55:31
In reply to AGOMELATINE is Marketed AND Available for $42 USD!, posted by Marty on September 25, 2008, at 11:08:47
i am really curious has anyone else tried this?
This is the end of the thread.
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