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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 3 of 3. This is the beginning of the thread.
Posted by TonyZ on February 29, 2008, at 17:33:02
Anyone out there use SAM-E for major depression in combination with other antidepressants. The Sam-E was working for me for about 2 years at 1200mg but recently I crashed. I've heard of some studies where it was combined with imipramine (tofranil) and other studies where it was combined with Celexa, but I'd like to hear from others that have tried and had success. I am crashing now and need some alternatives.
Posted by Racer on February 29, 2008, at 19:18:52
In reply to SAM-e for major depression, posted by TonyZ on February 29, 2008, at 17:33:02
In theory, I take 200mg BID along with Wellbutrin XR and Concerta. It's helpful, I think, although just now I'm in a very bad way despite it all. I have trouble with the second dose of it, too, because it should be taken on an empty stomach, so I often forget to take the second dose. I suspect I might feel a bit better if I were more consistent about that...
When I first started taking it, I was also taking Prozac -- along with the others mentioned above -- and was aware of a great improvement right away. Unfortunately, I don't do well with SSRIs, so had to stop the Prozac. It may have been the Prozac that caused the initial improvement, or it may have been the SAMe. I don't know.
Obviously, since you've been taking far more than I, it's not exactly parallel, and probably not very helpful. But, it's what I got, and so I'm passing it on.
Posted by bleauberry on February 29, 2008, at 21:39:06
In reply to SAM-e for major depression, posted by TonyZ on February 29, 2008, at 17:33:02
About a decade ago when I was taking Prozac and feeling stable yet very blah and emotionless I added SAMe. It worked and kicked in fast. It also seemed to poopout fast, or else maybe the emotional numbing of prozac was just too much and overcame the SAMe effect. I was not brave enough to go higher than 400mg. The SAMe trial lasted about 2 weeks. I crashed for a few days after I stopped it and then returned to my former prozac baseline. I realized afterward that SAMe had in fact been helping more than I thought it had, and that the initial surge of feeling high was different from the true effect of SAMe. And thus my confusion over the supposed poopout or tolerance.
Anyway, yeah, I tried it and feel it has definite potential. But it means experimenting, pioneering, and being careful. Actually, with any drug or supplement that's the way it is. All the research in the world will not predict what will happen with you or me.
> Anyone out there use SAM-E for major depression in combination with other antidepressants. The Sam-E was working for me for about 2 years at 1200mg but recently I crashed. I've heard of some studies where it was combined with imipramine (tofranil) and other studies where it was combined with Celexa, but I'd like to hear from others that have tried and had success. I am crashing now and need some alternatives.
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This is the end of the thread.
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